Parathyroid Hormone Flashcards
(25 cards)
Mild decreases in serum [Mg2+] __________ (stimulate/inhibit) PTH secretion
stimulate
Severe decreases in serum [Mg2+] __________ (stimulate/inhibit) PTH secretion
inhibit
Severe decreases in serum [Mg2+] may produce symptoms of _____________ (hyperparathyroidism/hypoparathyroidism)
hypoparathyroidism
The second messenger for PTH actions on its target tissues is?
cAMP
Bone resorption by PTH ________(will/will not) increase the serum ionized [Ca2+]
Will not
This effect on bone would not increase the serum ionized [Ca2+] because phosphate complexes Ca2+.
Resorption of the organic matrix of bone is reflected in increased ___________ excretion
hydroxyproline
PTH increases ________ reabsorption and _________ excretion in the renal tubules. (Calcium/Phosphate)
Calcium reabsorption
Phosphate excretion
________ generated as a result of the action of PTH on the proximal tubule is excreted
in the urine
cAMP
PTH increases intestinal Ca2+ absorption indirectly by stimulating the production of _______________ in the kidney
1, 25-dihydroxycholecalciferol
Primary hyperparathyroidism occurs most commonly due to _____________
Parathyroid adenoma
Primary hyperparathyroidism is characterized by _________ (increased/decreased) excretion of calcium in the urine.
Increased.
↑ urinary Ca2+ excretion is caused by the increased filtered load of Ca2+
What are the characteristics of hyperparathyroidism?
a. Hypercalcemia, Hypophosphatemia, High urinary phosphate, Low urinary Ca2+, High urinary cAMP, High bone resorption
b. Hypocalcemia, Hyperphosphatemia, High urinary phosphate, High urinary Ca2+, Low urinary cAMP, High bone resorption
c. Hypercalcemia, Hypophosphatemia, High urinary phosphate, High urinary Ca2+, High urinary cAMP, High bone resorption
c. Hypercalcemia, Hypophosphatemia, High urinary phosphate, High urinary Ca2+, High urinary cAMP, High bone resorption
Humoral hypercalcemia of malignancy is caused by ____________________ (PTH-related peptide/ PTH)
PTH-related peptide (PTH-rp)
High serum calcium, low serum phosphate, low PTH secretion and high phosphate excretion in urine is the characteristic of __________________?
Humoral hypercalcemia of malignancy
In humoral hypercalcemia of malignancy, PTH levels are ________ (high/low)?
low
due to feedback inhibition from the high serum Ca2+
In ________ (hyperparathyroidism/hypoparathyroidism) the bone usually remains strong.
hypoparathyroidism
Among the muscles of the body especially sensitive to
tetanic spasm are the _____________
Laryngeal muscles
Usual cause of death in people with hypoparathyroidism is ____________ (obstruction of respiration/depressed nervous system)
obstruction of respiration
Hypoparathyroidism is treated by __________ (PTH/Vitamin D)
VItamin D
__________ (Hyperparathyroidism/Hypoparathyroidism) is most commonly a result of thyroid surgery
Hypoparathyroidism
Hypoparathyroidism is characterized by
a. Low serum calcium, high serum phosphate and decreased phosphate excretion
b. High serum calcium, high serum phosphate and increased phosphate excretion
c. Low serum calcium, Low serum phosphate and decreased phosphate excretion
d. High serum calcium, Low serum phosphate and increased phosphate excretion
a. Low serum calcium, high serum phosphate and decreased phosphate excretion
Pseudohypoparathyroidism type 1a is the result of defective ________ in kidney and bone
Gs protein
In ____________________, organs become resistant to PTH
Pseudohypoparathyroidism
High PTH, Low calcium serum levels, and high phosphate levels are a sign of _______________
Pseudohypoparathyroidism
