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MTAP - Virology Book (Finals) > Part 1 (Intro-DNA Viruses) > Flashcards

Part 1 (Intro-DNA Viruses) Flashcards

Adenoviridae, Hepadnaviridae, Herpesviridae, Papillomaviridae, Parvoviridae, Polyomaviridae, Poxviridae (102 cards)

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1
Q

Number of families under DNA viruses

A

Seven

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2
Q

Number of families under RNA viruses

A

Fourteen

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3
Q

Viral members of Adenoviridae

A

Human adenovirus

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4
Q

Viral members of Hepadnaviridae

A

Hepa B virus

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5
Q

Viral members of Herpesviridae

A

HSV types I and II, VZV, CMV, EBV, human herpes viruses 6, 7, and 8

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6
Q

Viral members of Papillomaviridae

A

Human papilloma viruses

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7
Q

Viral members of Parvoviridae

A

Parvovirus B-19

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8
Q

Viral members of Polyomaviridae

A

BK and JC polyomaviruses

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9
Q

Viral members of Poxviridae

A

Variola, vaccinia, orf, molluscum contagiosum, monkeypox viruses

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10
Q

Viral members of Arenaviridae

A

Lymphocytic choriomeningitis virus, Lassa fever virus

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11
Q

Viral members of Astroviridae

A

Gastroenteritis-causing astroviruses

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12
Q

Viral members of Bunyaviridae

A

Arboviruses, (California encephalitis and Lacrosse viruses) nonarboviruses, (sin nombre), and related hantaviruses

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13
Q

Viral members of Caliciviridae

A

Noroviruses and hepatitis E virus

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14
Q

Viral members of Coronaviridae

A

Coronaviruses (including SARS coronavirus)

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15
Q

Viral members of Filoviridae

A

Ebola and Marburg hemorrhagic fever viruses

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16
Q

Viral members of Flaviviridae

A

Arboviruses ( including yellow fever, dengue, West Nile, Japanese encephalitis, and St. Louis encephalitis viruses) nonarboviruses (including hepatitis C virus)

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17
Q

Viral members of Orthomyxoviridae

A

Influenza A, B and C viruses

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18
Q

Viral members of Paramyxoviridae

A

Parainfluenza viruses, mumps virus, measles virus, RSV, metapneumovirus, Nipah virus

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19
Q

Viral members of Picornaviridae

A

Polio viruses, coxsackie A viruses, coxsackie B viruses, echoviruses, enteroviruses 68-71, enterovirus 72 (hepatitis A virus), rhinoviruses

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20
Q

Viral members of Reoviridae

A

Rotavirus spp., Colorado tick fever virus

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21
Q

Viral members of Retroviridae

A

HIV types 1 and 2, HTLV types 1 and 2

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22
Q

Viral members of Rhabdoviridae

A

Rabies virus

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23
Q

Viral members of Togaviridae

A

Eastern, Western, and Venezuela equine encephalitis viruses, rubella virus

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24
Q

Double-stranded deoxyribonucleic acid (DNA) genome; icosahedral capsid, no envelope; approximately 50 human serotypes

A

Adenovirus

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25
Adenovirus is first isolated from cultures of?
Adenoids and tonsils (1950s)
26
Site of latency of Adenovirus
Replication in oropharynx
27
Adenovirus serotypes 40 and 41 causes
Gastroenteritis in infants and children
28
Other adenovirus serotypes causes
Conjunctivitis and Keratitis
29
MOT of Adenovirus
Respiratory, fecal-oral, and direct contact (eye)
30
Diseases associated with Adenovirus (7)
Pharyngitis, pharyngoconjunctival fever, keratoconjunctivitis, pneumonia, hemorrhagic cystitis, disseminated disease, and gastroenteritis in children
31
What serotypes of Adenovirus is associated with respiratory epidemic in military recruits?
Serotypes 4 and 7
32
Pleomorphic, icosahedral enveloped viruses containing circular, partially double-stranded DNA
Hepadnavirus
33
Virion is called as
Dane particle
34
The surface antigen in hepadnavirus is called
Australia antigen
35
MOT of Hepadnavirus
Percutaneous exposure to blood, perinatal or sexual contact, direct contact
36
Site of Latency of Hepadnavirus
Liver
37
The most reliable marker for identifying HBV infection.
Hepatitis B surface antigen (HBsAg)
38
This antigen indicates the patient is in convalescence or previously vaccinated and has developed immunity.
Anti-HBsAg (antibody to surface antigen)
39
Presence of this indicates high infectivity and a chronic carrier state.
HBeAg (hepatitis B e antigen)
40
The best indication of active viral replication and a high state of infectivity
HBV DNA in the serum
41
Herpes is derived from the greek word which means
To creep
42
Double-stranded deoxyribonucleic acid (DNA) genome; icosahedral capsid with envelope; at least eight human viruses is known
Herpesvirus
43
Name the 8 herpes virus known
HSV-1, HSV-2, varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus (HHV)-6, HHV-7, and HHV-8
44
MOT of HSV-1 and HSV-2
Direct contact with infected secretions
45
Site of Latency of HSV-1 and HSV-2
Sensory nerve ganglia
46
HSV-1 infection occurs at
Oropharyngeal mucosa
47
HSV-2 infection occurs at
Genital sites
48
The lesions from HSV-1 and HSV-2 are referred to
herpes labialis, facialis, or febrilis; orolabial lesions
49
Samples of herpes viru should be inoculated into cell culture within
1 hour after collection
50
Herpes that causes a classic childhood disease, chicken pox and is characterized by the appearance of maculopapular rash
Varicella-Zoster Virus (VZV)
51
MOT of Varicella-Zoster
Close personal contact, especially respiratory
52
Site of latency 0f VZV
Dorsal root ganglia
53
VZV infects
Conjunctiva or mucosa of the upper respiratory tract, lymph nodes
54
Initial infection of VZV where infected T cells enters the blood stream is called
Primary Viremia
55
The second round of infection where the VZV infects the skin cells -> vesicular rash of chicken pox is called
Secondary Viremia
56
After a period of latency, the virus may initiate another acute infectious cycle. This reactivation produces the characteristic recurrent disease known as
Shingles
57
Shingles may be accompanied by a painful condition known as
Postherpetic neuralgia.
58
The herpes virus responsible for the disease infectious mononucleosis
Epstein-Barr Virus (EBV)
59
MOT of EBV
Close contact with infected saliva
60
Site of Latency of EBV
B lymphocytes
60
Disease caused by EBV
Infectious mononucleosis, progressive lymphoreticular disease, oral hairy leukoplakia in patients with HIV
61
The nonspecific heterophile antibodies that appear early during mononucleosis is called
Paul-Bunnell antibodies
62
The final diagnostic serologic marker of Burkitt lymphoma is called
Nuclear antigen (EBNA)
63
TORCH is an acronym for
Toxoplasma, Rubella, CMV and HSV-1
64
Another herpes virus that is a common cause of congenital birth defects and has been found to cause an mononucleosis-like illness
Cytomegalovirus (CMV)
65
MOT of CMV
Close contact with infected secretions, blood transfusions (WBCs), organ transplants, transplacental
66
Site of Latency of CMV
WBCs, endothelial cells, cells in a variety of organs
67
Herpes virus associated with the childhood disease roseola (exanthem subitum), both a lymphotropic viruses
HHV-6 and HHV-7
68
MOT of HHV-6 and HHV-7
Close contact via respiratory route;
69
Site of Latency of HHV-6 and HHV-7
T lymphocytes (CD4 cells)
70
A unique feature of the herpes virus family is their
Hallmark of latency (reactivation)
71
Small, nonenveloped, circular, icosahedram capsid double- stranded DNA viruses.
Papillomaviruses
72
Member of Papillomaviridae family that causes human warts which exhibit a tissue tropism for either cutaneous or mucosal tissue.
Human papillomaviruses (HPVs).
73
HPV-1 is associated with
Plantar warts
74
HPV-2 and HPV-4 are associated with
Common warts of the hands
75
HPV-6 and HPV-11 and others are associated with
Genital warts
76
MOT of HPV
Direct contact, sexual contact for genital warts
77
Site of Latency of HPV
Epithelial tissue
78
Other disease associated with HPV
Skin and genital warts, benign head and neck tumors, anogenital warts
79
Parvus is a latin term which means
Small
80
This virus is a nonenveloped, icosahedral, single-stranded DNA virus that may appear spherical on electron microscopy.
Parvovirus
81
The only parvovirus infective to human is
Parvovirus B-19
82
MOT of Parvovirus B-19
Close contact, probably respiratory
83
Disease associated with Parvovirus
Erythema infectiosum (fifth disease), aplastic crises in patients with chronic hemolytic anemias, and fetal infection and stillbirth
84
Are small, nonenveloped, circular, double-stranded DNA viruses that have been isolated from many species, including humans
Polyomavirus
85
The first human polyomaviruses are
JC (John Cunningham) and BK (a patient who had renal transplant) virus
86
MOT of Polyomavirus
Direct contact with infected respiratory secretions
87
Site of Latency of JC and BK polyomavirus
Kidney (B lymphocytes)
88
When JC virus reactivates, it results in disease in
CNS (Progressive multifocal leukoencephalopathy)
89
BK virus causes
Hemorrhagic cystitis
90
Recently discovered polyomavirus are
KI virus, MC virus, and Wu virus
91
MC virus causes
Merkell Cell carcinoma
92
The vaccine administered for those who are exposed in simian polyomavirus (SV40) in 1950s and 1960s
Salk Polio vaccine
93
The largest and most complex of all viruses; brick-shaped virion with nonconforming symmetry, referred to as complex; double-stranded deoxyribonucleic acid (DNA) genome
Poxviridae
94
MOT of small pox
Respiratory droplets
95
MOT of Molluscum contagiosum, orf, monkeypox
Direct contact
96
This virus played a crucial role in demonstrating the importance of vaccination to protect against disease.
Smallpox
97
Who recognized that milkmaids previously infected with cowpox were immune to infection with the smallpox virus?
Edward Jenner (1798)
98
The subtype of smallpox which caused the most severe disease (case fatality rate of 30%), occurred mainly in Asia;
Variola major
99
Subtype of smallpox associated with less severe disease and case fatality rates of 0.1% to 2%
Variola minor
100
Another member of the poxvirus family which causes single or small clusters of lesions (benign nodules)
Molluscum contangiosum virus
101
Another member of the poxvirus family and is transmitted from sheep to humans through human direct contact with infected sheep
Orf

MTAP - Virology Book (Finals) (3 decks)

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