Part 2: Particle QC

Question 1

what instrument did we use to measure particle size?

Answer 1

hemocytometer

Question 2

which RP is checked for clumping before use?

Answer 2

99m-Tc-Sulphur colloid

Question 3

which RP is checked for particle sizes and counted?

Answer 3

99mTc-MAA

Question 4

what is the acceptable MAA particle size?

Answer 4

10-90 um, none over 150 um with >90%

Question 5

what is an ideal MAA particle size?

Answer 5

20-40 um

Question 6

what is the acceptable range of MAA particles injected into a patient?

Answer 6

200,000-700,000 particles per patient dose

Question 7

in the hemocytometer grid, what size is the smallest square? largest square?

Answer 7

smallest = 50um x 50um
largest = 1mm x 1mm

Question 8

what is the formula to determine the # of particles in the hematocytometer?

Answer 8

particles/ml = (# of particles/0.1mm^3) * (1000mm^3/1ml)

Question 9

what are the two methods to determine particle number in a patient dose?

Answer 9

1. hemocytometer method
2. kit insert method

Question 10

what is the formula to determine the # of particles using the kit insert method?

Answer 10

particles/ml = (# of particles in vial/volume added)

Question 11

what is the formula used to determine particle number in a patient dose?

Answer 11

(# particles/ml * vol of pt dose) = # particles/dose

Question 12

when you see flocculation of colloid particles, which impurities do you assume is present in the eluate?

Answer 12

Al3+

Question 13

what is the ideal colloid size?

Answer 13

100-500 nm

Question 14

what size should a colloid not be larger than?

Answer 14

1000nm (1um)

Question 15

smaller particles have uptake in?
larger particles have uptake in?

Answer 15

smaller = res
larger = lungs