Part 3

Question 1

The study of the movement of drugs within biologic systems includes ABSORPTION, DISTRIBUTION, METABOLISATION AND EXTRACTION.

Answer 1

PHARMACOKINETICS

Question 2

Drugs advance from dosage form into a form that makes it biologically available for passage into systemic circulation.

Answer 2

ABSORPTION

Question 3

Solid or tablet form drug’s phase before absorption

Answer 3

Pharmaceutic Phase

Question 4

Determinants deciding whether drug will cross cell membrane: Lipid and water solubility.

Answer 4

PASSIVE DIFFUSION

Question 5

✔ Pinocytosis

Cell engulf drug particle and form protective coat around and transport across cell membrane.

Answer 5

ACTIVE TRANSPORT

Question 6

Orally taken drugs may be metabolized or become inactive. Large doses must be taken to attain intended effect.

Answer 6

FIRST-PASS EFFECT

Question 7

RATE OF DISTRIBUTION DEPENDS ON:

Answer 7

Adequate blood circulation
Protein binding
Drugs Affinity

Question 8

Process of alteration of structure of drugs or foreign substances.

Answer 8

METABOLISM

Question 9

FACTORS THAT ALTERS METABOLISM RATES:

Answer 9

Age
Health Status
Time of day
Emotional Status
Presence of other drugs in the body
Genetic variation
Disease state

Question 10

Kidneys are where the _____ commonly takes place.

Other site may be Biliary Tract, Feces, Enterohepatic Cycle later into the Kidney, Lungs, Sweat and Saliva, Mammary Glands.

Answer 10

EXCRETION

Question 11

PROCESS OF DRUGS WITHIN THE BODY DEPENDS ON:

Answer 11

Age
Nutritional Status
Ethnicity
Existing Physical Condition
Immune Status
State of Mind
Gender
Weight
Environment Factor
Time of day