part 3

Question 1

What are the uses of Cyclooxygenase (COX) Inhibitors?

Answer 1

suppress inflammation
relieve pain
reduce fever

Question 2

What does the inhibition of COX-1 (good COX) cause?

Also the AE’s of Cyclooxygenase (COX) Inhibitors.

Answer 2

gastric ulceration
bleeding
renal impairment

Question 3

What is the mechanism of action of Cyclooxygenase (COX) Inhibitors?

Answer 3

inhibits COX which is the enzyme that converts arachidonic acid into prostanoids

Question 4

What are the beneficial and harmful effects of inhibiting COX-1?

Answer 4

-Beneficial: 
protects against MI and stroke (due to reduced platelet aggregation) 
-Harmful: 
gastric erosion and ulceration
bleeding tendencies 
renal impairment

Question 5

What is th good COX and bad COX?

Answer 5

COX 1 = good

COX 2 = bad

Question 6

What does the inhibition of COX 2 (bad) cause?

Answer 6

largely beneficial 
-Beneficial: 
suppression of inflammation 
alleviation of pain and reduction of fever 
protection against colorectal cancer 
-Harmful: 
renal impairment 
promotion of MI and stroke

Question 7

What are the cyclooxygenase inhibitors with anti-inflammatory properties?

Answer 7

NSAID’s

Question 8

What are the 4 NSAID’s?

Answer 8

Aspirin
Celecoxin
Ibuprofen
Naproxen

Question 9

What cyclooxygenase inhibitors do not have anti-inflammatory properties?

Answer 9

acetaminophen

Question 10

What medication works best for musculoskeletal pain?

Answer 10

NSAIDs