Partial opioid agonists

Question 1

Buprenorphine

Answer 1

• 0.03mg/ml
• Moderate analgesic
• IV, IM, SQ, OTM administration
• Dogs and Cats: 0.02- 0.05 mg/kg q6h
• Adverse effects: high affinity for receptor, may be difficult to reverse
• Longer onset of action (45 min – 1 hour) regardless of route of administration- NOT A GOOD CHOICE FOR ACUTE PAIN!

Question 2

Buprenorphine SR

Answer 2

• 3 mg/ml concentration
• Dogs: 0.06 mg/kg
• Cats: 0.12 mg/kg
• SQ ONLY administration, distal limb
• LASTS 72 HOURS
• Adverse effects: dysphoria, inappetance
• Contraindications/ Cautions: adverse effects to Buprenorpine, hypersensitivity to drugs.

Question 3

Buprenorphine 24hr (Simbadol)

Answer 3

• 1.8 mg/ml concentration
• Cats: 0.24 mg/kg
• SQ ONLY administration, distal limb
• LASTS 24 HOURS
• Adverse effects: dysphoria, inappetance
• Contraindications/ Cautions: adverse effects to Buprenorpine, hypersensitivity to drugs, DO NOT CONFUSE DOG AND CAT DOSE!

Question 4

Butorphanol

Answer 4

• AKA Torbugesic (“Torb”)
• 10 mg/ml
• Partial opioid (Mu) agonist/antagonist, kappa agonist
• Mild sedative, minimal analgesic properties
• IV, IM, SQ, PO administration
• Sedative dose dogs and cats: 0.1 - 0.5 mg/kg
• Recommended starting dose: 0.25 mg/kg
• Antitussive (cough suppressant) dose in dogs: 0.05-0.1 mg/kg SC q6-12h
• Reversal agent: Naloxone 0.04 mg/kg
• excellent sedative effects when mixed with Dexmedetomidine 0.003 mg/kg
• Can be used as a partial reversal or rescue agent for mu-agonist opiates at a dose of 0.05mg/kg IV
• Adverse effects: possible dysphoria
• Contraindications/ Cautions: lower resp tract infections