Particulates Flashcards
What are particulate drug delivery systems?
Drug delivery systems composed of discrete particles ranging in size designed to encapsulate carry and deliver therapeutic agents to target sites
What are the advantages of using particulate drug delivery systems?
Improved drug stability
Controlled release kinetics
Targeted delivery to specific tissues or cells
Minimised side effects
Increased patient compliance
Personalised medicine
What are liposomes?
Ampiphilic vesicle with lipid bilayer and aqueous core
Drug is in the core or lipid bilayer or both
When are liposomes used?
Gene therapy
Lung therapeutics
Tumour targeting
Why do liposomes have high entrapping efficiency?
Because the drugs are positively charged and cells are negatively charged
What is PEGylation?
Protects liposomes from macrophage detection equals survival
What are the advantages of liposome drug delivery?
Organ targeting
Long acting potential
Drug protection – PEG
Increased immune response
Decreased toxicity
What are the disadvantages of liposome drug delivery?
High production cost
Leakage of encapsulated drug
Short half-life
Low solubility (lipids insoluble)
What are PLGA nano particles?
Encapsulate and deliver drugs to target site
What are the advantages of PLGA nano particles?
Regress toxicity
Biodegradable
Biocompatible
controlled release
Enhanced pharmacokinetics
What are the disadvantages of PLGA nano particles?
High production cost
Incomplete release
Burst release
Complexity of manufacturing
How are nano crystals administered?
Intramuscularly only
Why use nano crystals?
Small particles = increased surface area = increased desolation rate
Particles made it smaller via milling
What are the advantages of using nano crystals?
Prolong release
Enhanced bio availability
Improved stability
Side effects reduced
What are the disadvantages of nano crystals?
Manufacturing complexity
Toxicity
High production cost
Limited administration route – intramuscularly
