Polymer-drug Conjugates

Question 1

What is a pro drug and an example?

Answer 1

When the medication is inactive when administered but undergoes chemical change in the body to become active
- aspirin (acetyl salicylic acid> salicylic acid)

Question 2

What are polymer drug conjugates?

Answer 2

-Pro drug where drug is conjugated to a polymeric carrier (delivery vehicle)

Question 3

What are examples of cleavable linker bones?

Answer 3

-ester bonds
-Disulphide bonds
-Hydrazone bonds
-amide bonds

Question 4

What is an example of a polymer used in the situation?

Answer 4

PEG polymer
-Highly water soluble, uncharged, biocompatible and biodegradable

Question 5

What are stimuli sensitive conjugates?

Answer 5

-delivery systems responding to specific stimuli in the body to trigger drug release
-pH temperature enzymes
-Leads to size switching, phase switching or surface charge switching

Question 6

What is an example of a polymer drug conjugate and what is it used for?

Answer 6

-Somavet
- polymer is PEG
-Used in acromegaly (too much GH-overgrown tissue)