Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Year 5 Pathology > Past Papers Immuno > Flashcards

Past Papers Immuno Flashcards

(98 cards)

Start Studying
1
Q

CD4 deficiency, less IgA and IgG made

Unwell by 3 months

A

Bare lymphocyte syndrome type II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

CD40L
X-linked
can’t class switch so no IgA and IgG

A

Hyper IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

low Neut, 6 days every 3 weeks

What is Tx?

A

Cyclic neutropenia

give G-CSF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

X linked tyrosine kinase
BTK gene
No mature B cells, no antibodies, symptoms 3-6 months

A

Bruton’s X-linked hypogammaglobulinaemia

Only B cells (which mature in the bone marrow) are deficient. Ear infections are common as these individuals are susceptible to encapsulated bacterial infections) (or if question had said multiple cells lines affected = Anaplastic Anaemia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

congenital neutropenia

A

Kostmann’s syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Rheumatoid arthritis patient with mycobacterial infections

Cause?

A

Iatrogenic - TNFa antagonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Recurrent pneumococcal disease and meningitis

A

Complement deficiency - C5-C9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Immune deficiency that has improved with age but not mum is concerned about delayed speaking and language

A

Di George

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Marker of antibody mediated rejection

A

C4d

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Most important to match for rejection

A

HLA: DR>B>A

HLA = cell surface proteins, encoded on Chr6 by MHC. Present Ags to Tc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Preformed Ab activates complement
Thrombosis and necrosis
prevented by cross matching (HLA, ABO)

A

Hyper-acute rejection (mins-hrs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

CD4 T cells, type IV reaction-> cellular infiltrate

Treat with T cell suppressors

A

Acute Cellular rejection

Weeks - months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Antibodies attack vessels
Exposure -> proliferation + maturation of B cells -> effector phase - antibodies bind to graft endothelium (->vasculitis)

A

Acute - Ab mediated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Donor cells attacking host
Days-weeks
Rash, N+V, bloody diarrhoea, abdo pain, jaundice
Prophylaxis: methotrexate/cyclosporine, steroids

A

Graft vs Host disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

scl-70 topoisomerase

A

diffuse systemic scleroderma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

anti-cardiolipin

A

anti phospholipid syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

c-ANCA

A

Wegener’s granulomatosis (epistaxis and haematuria)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

AIRE mutation

A

Autoimmune Polyendocrinopathy Syndrome Type 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Grave’s which type of hypersensitivity?

A

Type II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Serum sickness which type of hypersensitivity?

A

Type III

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Atopic Eczema which type of hypersensitivity?

A

Type I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

dry eyes and mouth

A

Sjogrens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

weight loss, anti TTG antibodies, anti endomysial antibodies, steatorrhoea

A

Coeliac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

CREST

A

Calcinosis, Raynaud’s, Esophageal dysmotility, Sclerodactyly, Telangiectasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
anti ds DNA
SLE
26
anti parietal cell > anti intrinsic factor
Pernicious anaemia
27
Pollen/fruit ross-react
Oral Allergy Syndrome | Sx in mouth only
28
Bluish mucosa Seasonal - allergen desensitisation Tx?
Allergic rhinitis Nasal corticosteroid or oral antihistamine
29
C1 esterase inhibitor is Mx for
``` Hereditary angioedema (angioedema, abdo pain, ascites, facial/testinal oedema) ```
30
Urticaria Mx | - idiopathic, food, drugs, latex, viral, infection, exercise
H1 receptor antagonist
31
Angioedema, SOB, low BP
Anaphylaxis | Mx - O2 and fluids, help, IM 500mcg Adr, inhaled bronchodilator, 100mcg Hydrocortisone IV, Cloramphenamine 10mcg IV
32
Main cellular source of histamine
Mast cells
33
How do you measure mast cell degranulation
Mast cell tryptase
34
Chemokine responsible for promoting eosinophil growth
IL-5
35
Engulf debris
Macrophage
36
Secrete Igs, cytokines, present antigens
B cells
37
Present antigens; migrate to lymph nodes when activated
Dendritic cells
38
Cytotoxic - MHC I
CD8 Tc
39
HIV Co-receptor
CXCR4/CCR5
40
HIV Receptor on cell wall which facilitates entry
gp120
41
HIV Antigen for non-neutralising antibodies
p24
42
HIV drug that inhibits an enzyme that breaks down proteins
Protease inhibitors
43
Can be used for RA
Rituximab
44
For ank spond (with methotrexate), antiTNFalpha receptor
Etarnercept
45
Pooled Ig given for
CVID
46
Prophylaxis of allograft rejection
Basiliximab (Anti CD25, stops Tc prolif) Anti-thymocyte globulin (affects Tc)
47
RA Mx (also for Castleman's) Antibody to IL6 receptor reduces macrophage/T cell/B cell/neutrophil activation
Tocilizumab + anti TNFa e.g. Etanercept
48
Mx Psoriasis | Antibody to p40 subunit of IL12 and IL23
Ustekinumab
49
Osteoporosis Mx | Ab to RANK ligand (stops osteoclast differentiation)
Denosumab + bisposphonate
50
Mx Wegener's Antiproliferative agent - B>T cells affected
Cyclophosphamide
51
Chronic granulomatous disease Mx
IFN-g
52
Temporal arteritis with high ESR Mx
Prednisolone
53
Anti TNFalpha | Used for loads - psoriasis, crohn’s rheumatoid
Infliximab
54
Routine but not given to immunocompromised children
MMR
55
Travel vaccine not given to someone with ank spond on TNFalpha inhibitor
Yellow Fever
56
12-13 year old girls vaccine
HPV
57
Vaccine every 5 years given to splenectomy patient
Pneumococcal
58
Targets neuraminidase/haemogglutinin
Amantadine - influenza A only, targets M2 channel | Oseltamivir, zanamivir, sialic acid - NA inhibitors
59
Vaccine given as post exposure prophylaxis
rabies
60
Structure varies yearly
Influenza
61
Vaccine that eradicated small pox
Vaccinia
62
Hep B type vaccine
conjugate vaccine
63
Transplant complications
``` Lymphoproliferative disease (EBV) Kaposi's sarcoma ```
64
Cause progressive multifocal leukoencephalopathy
JC virus
65
Boy whose father got TB after BCG now currently has mycobacterium infection after BCG
IFN gamma receptor deficiency
66
A teenage girl who when she goes cross country running gets an erythematous rash on her legs. It is well controlled by antihistamines
cold urticaria
67
Man can eat apple pie. But if he eats fresh apples and pears, he gets inflamed lips
OAS
68
Man has an allergic reaction during surgery and who’s lips becomes swollen/oedematous when blowing up balloons as his daughter’s birthday party
Type 1 hypersensitivity
69
Bloated after drinking milk but not IgE mediated
lactose intolerance (enzyme deficiency rather than IgE mediated)
70
A girl with a sore throat is given penicillin and develops a rash. She is found to have EBV.
Drug reaction (serum sickness)
71
Teenager + sore throat 3 causes cause if rapid antigen testing is negative and monospot/heterophile antibody test positive cause if monospot/heterophile antibody test negative (therefore not EBV) + Rapid antigen test negative
Strep throat EBV CMV RAT -ve/ monospot +ve = EBV CMV
72
Paviluzimab use
monoclonal Ab for RSV
73
HIV immune response: neutralising AB Non-neutralising Ab
neutralising Ab - anti-gp120 | non-neutralising - anti- p24
74
What cell is inhibited by the presence of MHC1 on cells
NK cells
75
What cell is increased in cases of a parasitic infection
eosinophils
76
Woman presents with aches all over, (diffuse swelling), and joint stiffness?
Rheumatoid arthritis
77
A patient with well controlled HIV, who is currently on HAART. What would you measure?
CD4 via FACS (flow cytometry) viral load
78
A women with known SLE presents with an exacerbation of her SLE/worsening symptoms. What do you measure?
C3 and C4
79
Rhesus D negative woman is having a Haematopoietic stem cell transplant (HSCT) and is CMV IgG negative. What is the most important thing to ensure in the transplant? a. HLA of donor and recipient identical b. Related to recipient and HLA identical c. HLA haploidentical d. CMV IgG negative e. Donor not Rhesus match
CMV IgG negative
80
HIV RNA forms HIV, via which error prone enzyme?
Reverse transcriptase
81
Which of these vaccines must not be given to a pregnant woman: a. MMR b. Hep B c. DTP
MMR (live vaccine) as is BCG, typhoid
82
5 special drug treatments. Which drug can be used to treat some malignancies and affects T cell activity? a. Infliximab b. Pembrolizumab c. Rituximab
Rituximab
83
Gout man on allupurinol | Which meds would need to be altered to prescribed allopurinol?
Azathioprine
84
Man has intermittent + tongue swelling for the past 2 years unresponsive to anti-histamines is on aspirin and ACE inhibitor likely cause?
Drug induced reaction - angioedema is commonly associated with ACE-inhibitors and NSAIDs.
85
Cell sits immature in periphery | matures + presents to T cells
Dendritic cells
86
cell inhibited by MHC1 on cells
NK cells
87
Heterophile antibody
Infectious mononucleosis
88
Anti-Jo-1
Dermatomycositis
89
Anti-Thyroperoxidase/throglobulin AB
Hashimoto's thyroiditis
90
Anti-U1RNP Ab (speckled pattern)
Mixed CTD
91
p-ANCA
Microscopic polyangiitis | Churg-Strauss
92
congenital heart block in infant of mum with SLE
Anti-Ro Ab
93
AIRE Mutation
– Autoimmune polyendochrinopathy syndrome 1 endocrinopathies: T1DM, addison's, hypothyroidism
94
cancer | Bruton Tyrosine kinase inhibitor ibrutinib be used in
CLL
95
Rhesus D negative woman having a Haematopoietic stem cell transplant is CMV IgG negative must ensure that...
transplant is CMV IgG negative
96
vomiting, white cell casts in urine
pyelonephritis
97
pain, haematuria
renal calculus
98
most specific marker for Rheumatoid arthritis
Anti-Cyclic Citrullinated Peptide

Year 5 Pathology (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions