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Year 5 Pathology > Path VSAs > Flashcards

Path VSAs Flashcards

1
Q

What does Denosumab target

A

Receptor activator of nuclear factor kappa-B Ligand (RANKL)

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2
Q

Turkish man
fever
history of recurrent chest infections
mutation in the MEFV gene

A

ME-FV = Familial MEditerranean FeVer

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3
Q

mixed pattern auto-inflammatory condition over 90% heritability
sacroiliac joint

A

Ankylosing spondylitis

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4
Q

hyperthyroidism Sx
low TSH and high thyroxine
NO good uptake on technetium scan

A

Viral De Quervain’s thyroiditis (virus releases thyroxine stores)

Good uptake bilaterally = Grave’s Disease
nodular = Toxic multinodular goitre
single mass uptake = toxic adenoma (Ca)

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5
Q

measure the turnover of bone, and is raised in people who have Paget’s, Osteomalacia / Rickets?

A

Alkaline Phosphatase

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6
Q

elderly man has a fall
no LoC
two days later confusion
where is the likely site of bleeding?

A

subdural

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7
Q

clotting factor that falls most rapidly after administering warfarin

A

FVII

FVII > Protein C/S > F 9 > F 2

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8
Q

blood marker MEDULLARY thyroid Ca

A

calcitonin

(and CEA - Carcinoembryonic antigen )

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9
Q

Marker Papillary (commonest) & Follicular thyroid carcinoma

A

Thyroglobulin

common thyroid ca
Papillar>Follicular>Medullary
PAy FOr ME

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10
Q

drug is used to treat severe falciparum malaria

A

artesunate

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11
Q

massive splenomegaly
JAK2 V617F mutation leucoerythroblastic picture
tear-drop poikilocytes (dacrocytes)

A

myelofibrosis

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12
Q

African man

with Burkitt’s lymphoma is given Rasburicase. Develops haematuria with irregularly contracted cells

A

G6PD

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13
Q

aortic valve replaced 3 months ago
few weeks later
jaundice, Hb-urea (haemoglobinuria), and raised reticulocytes

A

MAHA

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14
Q

cancer is present if keratin and intercellular bridges

A

Squamous Cell Carcinoma

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15
Q

high Na+, low K+, and low renin

A

Conn’s - Primary Hyperaldosteronism

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16
Q

common condition can be treated with drugs that target with TNF, IL-17 and IL-12/23

A

Psoriasis

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17
Q

vasculitis external carotid

A

Temporal arteritis

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18
Q

Type of amyloidosis

A

reactive

19
Q

type of amyloid deposited in multiple myeloma

A

Ig light chain

20
Q

one of types/groups of drugs used to treat HIV

A

Nucleoside Reverse Transcriptase Inhibitors

Protease inhibitor

21
Q

main class of drug used to treat HIV

A

Nucleoside Reverse Transcriptase Inhibitors

22
Q

zoonotic disease does the Ixodes Tick cause

A

Lyme disease

23
Q 
absence UDP gluconoryl transferase
jaundice + kernicterus 
high unconj bili
death in 1 yr of life
AR inheritance
A

Crigler-Najjar syndrome

24
Q

reduced activity UDP gluconoryl transferase
AD inheritance
harmless raised unconj bili

A

Gilbert’s

25
Q

Medical certificate of Cause of Death OR consented autopsy

A

Know the cause of death

26
Q

unsure of cause of death

A

Discuss w/ coroner about death certificate or autopsy

27
Q

unknown cause death
violent death
died in prison/custody/MH hospital

A

autopsy

28
Q

Cause of death unknown
Not seen by Dr during last illness OR last 14 days
During or within 12m of pregnancy
Death in custody
Death whilst detained under MHA
Death due to suicide, accident/trauma (inc domestic), industrial, peri-operative, abortion, anaesthetic care, lack of medical care, murder, self-neglect or ANY DOUBT (inc if injury was years ago)

A

refer to coroner

29
Q

Person with well controlled HIV and hyperlipidaemia due to HAART medication.
Deteriorated and found wedge shaped lesion on CTPA. Suffered from a cardiac arrest and died.

A

1a pulmonary infarction/MI 1b Hyperlipidaemia
2 HIV

CANNOT put FAILURES (heart/liver/resp) or cardiac arrest as 1a

30
Q

Patient with HIV was recently involved in an RTA

Fill in MCCD?

A

NO

31
Q

Woman who’s daughter and husband disagree on post mortem

A

refer to coroner

32
Q

Enzyme raised in biliary obstruction

A

Gamma glutamyltransferase

33
Q

High sodium, high potassium, high serum osmolality, low urine osmolality

A

Diabetes insipidus

34
Q

euvolaemic
low serum osmolality
urine NA >20
normal renal, adrenal, thyroid

A

SIADH

35
Q

no particles in urine

A

urine specific gravity

36
Q

commonest cause hyperkalaemia

A

AKI

37
Q

Vegan with megaloblastic anaemia

A

B12 deficiency

38
Q

Crohn’s with Megaloblastic anaemia

A

B12 deficiency

39
Q

Deficiency associated w/ Lacking IF

A

B12

pernicious anaemia

40
Q

Dementia, Dermatitis (scaly), Diarrhoea

Pellagra

A

Niacin def

41
Q

Tx Beri Beri

A

B1 (thiamine)

42
Q

Nutritional deficiency
glossitis
dementia
Pernicious anaemia

A

B12

43
Q

Dermatitis, anaemia, neuropathy

A

B6: Pyridoxine

44
Q

72 year old with headache - High CA, normal phos, normal PTH, High ALP

A

Primary Hyperparathyroidism

Year 5 Pathology (13 decks)

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