Path Flashcards
(25 cards)
Ppl with Hashimoto’s are at risk for what?
B cell lymphoma
A/w renal cell carcinoma in a child?
VHL
Histo: Orphan annie eyes
A/w papillary carcinoma of the thyroid
Histo: psammoma bodies
A/w papillary carcinoma of the thyroid
Histo: nuclear grooves
A/w papillary carcinoma of the thyroid
Hx: irradiation as a child
A/w papillary carcinoma of the thyroid
RET mutations
A/w medullary OR papillary carcinoma of the thyroid
Thyroid Histo: amyloid deposition
A/w medullary carcinoma of the thyroid
Thyroid Histo: (+) stain for calcitonin
A/w medullary carcinoma of the thyroid
MEN 2A gene
A/w medullary carcinoma of the thyroid
MEN 2B gene
A/w medullary carcinoma of the thyroid
Hx: “stones, bones, groans, & psychiatric undertones”
A/w primary hyperparathyroidism
Hx: elderly with excessive thirst/polyuria
A/w Acquired DI (may be nephrogenic or central)
Thyroid turned completely fibrosed?
A/w Riedel’s thyroiditis, common in middle-aged F
Histo: granulomas and giant cells in thyroid?
A/w De Quervain’s thyroiditis, but may also be TB (if necrotizing) or sarcoidosis
Gross: diffusely slightly enlarged, tender thyroid, a/w viral infection?
A/w De Quervain’s thyroiditis
Gross: bronze skin
A/w Addison’s disease (adrenal insufficiency, usually autoimmune)
Lab: morning serum cortisol below 3 mcg/dL
A/w Addison’s disease (adrenal insufficiency, usually autoimmune)
Common cause of Addison’s outside the US?
TB
Hx: Carpal tunnel
A/w Myxedema hypothyroidism
- predisposes to carpal tunnel bc of fluid excess compressing the nerve
Thyroid Histo: germinal centers
A/w Hashimoto’s thyroiditis (hypothyroidism)
Thyroid histo: lots of lymphocytes and big pinkish cells
A/w Hashimoto’s thyroiditis
- big pink cells are Hurtle cells
Vitiligo
A/w Addison’s (adrenal insufficiency)
- bc of autoimmune destruction of melanocytes
- looks like hypopigmented patches of skin
Thyroid histo/biopsy: diffusely eosinophillic change (looks magenta or darker)
A/w Hurthle cell metaplasia (adenoma or carcinoma)
