path of skin DSA 3

Question 1

what has increased thickness of the stratum corneum, absent granulosum, fishy, scaly?

Answer 1

ichthyosis

Question 2

AR, build up of compacted stratum cornea, loss of normal basket weave pattern

Answer 2

lamellar ichthyosis

Question 3

what type of reaction is urticara?

Answer 3

type 1 hypersensitivity. IgE mediated.

Question 4

what are some associated terms with eczema?

Answer 4

pruritus, red, bliters, oozing, spongiosis (edema)

Question 5

what is acute eczema?

Answer 5

weeping, erythematous, rash with vesicles

Question 6

what is chronic eczema?

Answer 6

dry, thickened skin caused by continual scratching

Question 7

what type of hypersensitivity is atopic dermatitis?

Answer 7

type 1 IgE mediated

Question 8

what is spongiosis?

Answer 8

accumulation of edema fluid within the intercellular spaces of the epidermis.

Question 9

what has spongiosis and is a type IV reaction?

Answer 9

poison ivy

Question 10

what is the mechanism for poison ivy?

Answer 10

antigens at epidermal surface taken up by dendritic langerhans cells, migrate to draining lymph nodes. Antigens presented to CD4 cells that develop to memory cells. These cells migrate to affected skin sites where they release cytokines and factors that recruit inflammatory cells.

Question 11

type IV reaction, CD4 lymphocytes, intraepidermal vesicles

Answer 11

acute allergic contact dermatitis

Question 12

which dz is characterized by a deficiency in C1 esterase inhibitor?

Answer 12

hereditary angioedema

Question 13

What happens when you have a deficiency in C1 esterase inhibitor?

Answer 13

decreased conc of C2 and C4 in classic pathway, increasing conc of cleavage products C2a and C4a - anaphylatoxic activity.

Question 14

Target skin lesions?

Answer 14

central area of necrosis with surrounding macular erythema. Erythema multiform.

Question 15

epithelial cells killed by CD8+ cells. subepidermal bullae

Answer 15

erythema multiform

Question 16

silver scaly scales, salmon colored plaques, Rete ridges

Answer 16

psoriasis

Question 17

what is the koebner phenomenon?

Answer 17

lesion spread by trauma. Psoriasis

Question 18

Munro microabscesses

Answer 18

neutrophils in superficial epidermal layers. psoriasis.

Question 19

what HLA is psoriasis associated with?

Answer 19

HLA CW 0602. Arthritis HLA B27

Question 20

Auspiz sign

Answer 20

Psoriasis. pinpoint bleeding when you remove the scales.

Question 21

greasy yellow dandruff flakes over red inflamed skin

Answer 21

seborrheic dermatitis