Path Pt2 Flashcards
(30 cards)
In the context of Aggressive Periodontitis vs. Chronic Periodontitis, what is the primary mechanism or clinical presentation associated with disease progression?
D. A familial pattern with neutrophil dysfunction
In the context of Cytokines and Chemokines in Periodontal Disease, what is the key function of IL-1β in pathogenesis?
C. Activation of osteoclasts and upregulation of MMPs
In the context of Host Immune Response – T Cells and Plasma Cells, what marks the established lesion stage in gingivitis?
C. Plasma cell infiltration and antibody production
In the context of Alveolar Bone Resorption and Osteoclast Activation, what mediates osteoclast differentiation in periodontitis?
C. RANKL and IL-1β
In the context of Red Complex Bacteria and Pathogenicity, what is the critical virulence factor of Porphyromonas gingivalis?
B. Gingipains that degrade complement and immunoglobulins
In the context of Initial Colonization and Plaque Formation, which bacterial species is the first to adhere to the acquired pellicle?
C. Streptococcus sanguinis
In the context of Microbial Succession in Plaque, what shift occurs as biofilm matures?
C. Increase in obligate anaerobes
In the context of Neutrophils, which enzyme is released during the oxidative burst that contributes to bacterial killing?
A. Myeloperoxidase
In the context of Macrophages, what cytokine is primarily released to activate T cells in chronic inflammation?
C. IL-12
In the context of Periodontitis vs. Gingivitis, what differentiates the bacterial profile in periodontitis?
B. Dominance of spirochetes and Gram-negative rods
In the context of Systemic Links to Periodontal Disease, which systemic condition is most associated with increased periodontal bone loss?
A. Diabetes mellitus
In the context of Enzymes and Matrix Degradation, which enzyme is primarily involved in the degradation of gingival collagen?
B. MMP-8
In the context of Host Immune Response - Plasma Cells, what is the primary antibody type produced in the established lesion stage?
B. IgG
In the context of Biofilm Structure and Maturation, what is the primary nutrient source for subgingival bacteria in chronic periodontitis?
B. Host tissue breakdown products
In the context of Alveolar Bone Resorption, what cell type is directly activated by RANKL?
A. Osteoclasts
In the context of Microbial Virulence, which bacterial component is responsible for immune evasion by P. gingivalis?
C. Gingipains
In the context of Aggressive Periodontitis, what genetic factor is associated with increased susceptibility?
B. Polymorphism in IL-1 gene
In the context of Cytokine-Mediated Bone Loss, what cytokine is predominantly associated with osteoclastogenesis?
B. TNF-α
In the context of T Cell Activation in Periodontitis, which cytokine is crucial for Th1 differentiation?
B. IFN-γ
In the context of Clinical Presentation and Diagnosis, which clinical feature is a hallmark of chronic periodontitis?
B. Deep pockets and bleeding on probing
In the context of Red Complex Bacteria, which pathogen is NOT part of the red complex?
B. Prevotella intermedia
In the context of Biofilm Structure, what is the significance of extracellular polymeric substances (EPS)?
B. Act as a barrier to antimicrobial agents
In the context of Alveolar Bone Resorption, what enzyme degrades collagen in the periodontal ligament?
B. MMP-13
In the context of Immune Evasion, how does T. denticola inhibit phagocytosis?
C. Secretes proteolytic enzymes
