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Patho MPL 1 cards Flashcards

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2
Q

Most common cancer in children

A

ALL

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3
Q

Most common leukemia in adults and elderly

A

CLL

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4
Q

Leukemia most responsive to chemotherapy

A

ALL

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5
Q

Organs that contain barriers which make it difficult for chemotherapy to reach in ALL

A

Sanctuary sites (CNS and testes)

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6
Q

Most numerous Auer rods

A

APML

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7
Q

Highly responsive to all-trans retinoic acid

A

AML

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8
Q

Stain used for hairy cells

A

Tartate-resistant acid phosphatise (TRAP)

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9
Q

Large cells with multiple nuclei or a single nucleus with multiple nuclear lobes, each half is a mirror image of the other

A

Reed sternberg cells (owl’s eyes)

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10
Q

Most common type of Hodgkin’s Lymphoma

A

Nodular sclerosis

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11
Q

Most common primary hypercoagulable state

A

Factor V leiden mutation

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12
Q

Type of hodgkin’s lymphoma with the worse prognosis

A

Lymphocyte depleted

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13
Q

Multi-lobed nucleus in lymphocyte predominant hodgkin’s lymphoma

A

Popcorn cells

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14
Q

Generally painless LN, becomes painful with alcohol consumption

A

Hodgkin’s lymphoma

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15
Q

Most common hematopoietic malignancy

A

NHL

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16
Q

Most common form of indolent NHL

A

Follicular lymphoma

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17
Q

Most common form of NHL

A

Diffuse large B-cell lymphoma

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18
Q

Most common and most deadly plasma cell neoplasm presenting as tumorous masses scattered throughout the skeletal system

A

Multiple myeloma

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19
Q

Sky-blue cytoplasmic puddles or patches of dilated endoplasmic reticulum in leukocytosis

A

Dohle bodies

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20
Q

Vehicle used for delivery of chemotherapy to CNS sanctuary sites of ALL

A

Ommaya reservoir

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21
Q

Distinctive needle-like azurophilic granules in AML

A

Auer rods

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22
Q

Philadelphia chromosome

A

CML

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23
Q

Scattered macrophages with abundant wrinkled, green-blue cytoplasm in CML

A

Sea-blue histiocytes

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24
Q

Dermatologic solid focus of leukemia outside the BM in CML blast crisis

A

Chloroma

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25
Q

Lymphocytes destroyed upon smearing on slide

A

Smudge cells

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26
Complication of CLL presenting with diffuse histiocytic lymphoma or transformation into diffuse large B cell lymphoma
Richter syndrome
27
In what cancer do you see Reed-sternberg cells?
Hodgkin's lymphoma
28
Nuclear remnants phagocytosed by interspersed macrophages with abundant clear cytoplasm in Burkitt's lymphoma
Starry sky pattern
29
Multilobulated nuclei in Adult T-cell lymphoma
Cloverleaf/Flower cells
30
Seeding of blood by malignant T-cells from a localized skin neoplasm presenting as diffuse erythema and scaling of entire body surface
Sezary syndrome
31
Excess light chains synthesized by neoplastic cells which are excreted in the urine
Bence-Jones proteins
32
Histologic hallmark of mycosis fungoides with a hyperconvoluted or cerebreform nuclei
Sezary-Lutzner cells
33
Band-like dermal infiltrates with invasion by single cells or small clusters into the epidermis
Pautrier microabscesses
34
Fiery red cytoplasm (MM)
Flame cells
35
Multiple grape-like cytoplasmic droplets (MM)
Mott cells
36
Blue globular nuclear inclusions (MM)
Russell bodies
37
M proteins causes RBCs in PBS to stick in linear arrays
Rouleaux conformation
38
Starry sky pattern
Burkitt's lymphoma
39
Which conditions would produce a dry tap?
hypocellular neutropenia, hairy cell leukemia, myelofibrosis
40
Cancers associated with EBV
Paracortical hyperplasia of chronic lymphadenitis, Hodgkin's lymphoma, Burkitt's lymphoma
41
Presents with mediastinal mass
Thymoma, Substernal thyroid, Teratoma, Lymphoma, ALL
42
X-linked dominant disorders
Alport syndrome and Vitamin D resistant
43
Major source of plasma LDL
IDL
44
First human inborn error of metabolism to be discovered
Alkaptonuria
45
Most common lysosomal storage disorder
Gaucher disease
46
Most common acquired cause of mental retardation in newborns
Fetal-alcohol syndrome
47
Most common genetic cause of mental retardation in newborns
Down syndrome (Trisomy 21)
48
2nd most common genetic cause of mental retardation
Fragile X syndrome
49
Most common chromosomal disorder
Down syndrome (Trisomy 21)
50
Mental retardation, clenched hands with overlapping fingers, micrognathia, rocker bottom feet, VSD, early death
Trisomy 18, Edwards syndrome
51
Mental retardation, cleft lip and palate, polydactyly, holoprosencephaly, rocker bottom feet, VSD, polycystic kidney, early death
Trisomy 13, Patau syndrome
52
CATCH 22, due to aberrant development of 3rd and 4th branchial pouches
DiGeorge syndrome
53
Most common cause of primary amenorrhea
Turner syndrome
54
Elfin facies, microdeletion of long arm of chromosome 7, extreme friendliness
Williams syndrome
55
Anti-scl70
Diffuse scleroderma
56
Anti-centromere antibodies
Limited scleroderma
57
Components of CREST syndrome
Calcinosis, Raynaud's, Esophageal dysmotility, Sclerodactyly, Telangiectasia
58
Very low levels of all immunoglobulins, virtual absence of B cells due to tyrosine kinase mutation
Bruton's agammaglobulinemia, X-linked hypogammaglobulinemia
59
Defect in B-cell maturation to plasma cells; Most common form of severe antibody deficiency
Common variable immunodeficiency (CVID)
60
Features of DiGeorge syndrome
Cardiac defects, abnormal facies, Thymic aplasia, Cleft palate, Hypocalcemia, 22q11.2 deletion
61
Profound deficit of T cells
DiGeorge syndrome
62
Mutation in gene encoding common gamma chain/IL-2 receptor gamma; ADA deficiency
Severe combined immunodeficiency (SCID)
63
Inability to mount IgM response
Wiskott-Aldrich Syndrome
64
Mutations in DNA repair enzymes
Ataxia telangiectasia
65
Lack of NADPH oxidase activity; failure of oxidative burst
Chronic granulomatous disease
66
Failure of phagolysosomal fusion
Chediak-Higashi syndrome
67
Most common complement defect
C2 deficiency
68
Deficiency of decay-accelerating factor (DAF)
Paroxysmal nocturnal hemoglobinuria
69
Apple green colored birefringence in polarized light with congo red
Amyloidosis
70
Most common and most serious form of Amyloidosis
Renal amyloidosis

Patho MPL 1 (4 decks)

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