pathogenesis Flashcards
(64 cards)
pathogenesis
1) the mechanism by which microorganisms cause disease
where does crystal violet bind
1) peptidoglycan
why stain bacteria
1 )to see them
2) distinguish + from -
which type have a pentaglycine bridge in their peptidoglycan
1) +
if transpeptidases bind penicillin what does this imply
1) enzyme that links the peptides in peptidoglycan will be inactivated
where do peptides bind on the glycans
1)
murein
1) is another name for peptidoglycan
which bacteria have teichoic acid and lipoteichoic acid
1) gram +
what kind of phospholipids are found in the cytoplasmic membrane of bacteria
1) dipalmitoylphosphatidylcholine in our lungs
2) Phosphatidylethanol?
why type of secretion systems inject exotoxins into other cells
1) type III and IV
what diseases do p gingivalis and aeruginosa cause
1) periodontitis
2) cystic fibrosis
why is there a lag phase in bacterial growth
1) allow bacteria to adapt to environment
stationary phase
1) reproducing at same rate as death
endospores
1) can survive in tough environment
which pathogenic bacteria form endospores
1) clostridium species
- tetani, etc
how was semi conservative replication discovered
1) labeled and unlabeled DNA
transcriptional regulation in bacteria
1) discovered by French people - Jacques Moneau?
endemic
1) constantly present at a low levell
epidemic
1) infection occurs much more frequently than usual
pandemic
1) worldwide distribution
cause disease by 2 mechanisms
1) invasion and inflammation
2) toxin production
- exotoxin
- endotoxin - LPS of cell wall in gram - bacteria cause fever and shock
symptoms of shock
1) low BP
2) high or low temp
3) cool, pale arms
4) rapid heart rate
5) shortness of breath
septic shock
1) broad spectrum anitboitic
2) then narrow spectrum
3) vasopressors
4) corticosteroids and insulin
aspects of infection control
1) symptomatic
2) subclinical
- unapparent
3) latent
- stable
