Pathogenesis Flashcards Preview

Perio I > Pathogenesis > Flashcards

Flashcards in Pathogenesis Deck (34)
Loading flashcards...
1

What are the four stages of lesion establishment?

1-inital lesion (2-4 days)
2-Early lesion (4-7 days, acute gingivitis)
3-Established lesion (2-3 weeks, chronic gingivitis)
4-advanced lesion (>3 weeks, periodontitis, pockets form and radiograph shows bone loss)

2

What are the two types of immune responses?

1-innate (non specific)
2-acquired (adaptive and specific)

3

What are the 5 immune components of for plaque accumulation response?

1-mast cells
2-acute phase proteins
3-complement
4-PMNs
5-Antibodies

4

Histamine and leukotrines do what?

-dilates small blood vessels and increases their permeability
-constricts bronchi
(leukotrines also cause chemotaxis of leukocytes)

5

TNF does what?

recruits granulocytes and induces fever

6

Prostoglandins do what?

increase vascular permeability and regulate immune responses

7

What are 6 plasma proteins that increase due to microbial infection? (first 5 are associated with hear disease)

1-C-reactive protein
2-fibrinogen
3-complement
4-mannose-binding protein
5-metal-binding proteins
6-alpha-anititrypsin-anticymotrypsin

8

Which plasma protein in associated with a 2-5 fold increased risk of MI (Myocardial infarction)

C-reactive protein

9

What is complement and where is it synthesized?

11 protein glycoprotein that makes up 10% of normal sera that interacts with IgG and IgM. It is made in the liver and small intestine

10

What are the 3 main types of PMN granules?

1-Azurophilig granules (primary)
2-Specific granules (secondary)
3-Tertiary granules

11

What % of blood leukocytes are neutrophils?

55-65%

12

What % of blood leukocytes are Eosinophils?

2-4%

13

What % of blood leukocytes are basophils?

0-1%

14

What % of blood leukocytes are monocytes?

3-8%

15

What % of blood leukocytes are other types?

25-35%

16

What are 4 types of Professional Antigen Presenting Cells?

1-Macrophages
2-Langerhan cells
3-Dermal dendritic cells
4-B cells

17

Which CD class receptor binds with MHC I?

CD8 (An increase can cause sjogrens, a decrease causes chronic fatigue)

18

What cell type is responsible for most of the localized damage in periodontal inflammation?

Fibroblasts

19

What are 3 main inflammatory mediators that can cause tissue damage in response to sub gingival plaque?

-Cytokines (interleukins)
-Prostanoids
-MMPs

20

Treatment of periodontal disease often lowers levels of what interleukin?

IL-1

(High body fat can also increase IL)

21

IL-2, IL-4 generally increase in what disease?

Periodontal disease

22

CD4 cells secrete what?

Interleukins

23

Which interleukin plays a role in bone resorption?

IL-6

24

IL-7 is secreted by what?

Bone marrow stromal cells

25

IL-8 stimulates chemotaxis of what?

PMNs (also MMP activity)

26

IL-9 induces growth of what?

Mast cells

27

IL-10 inhibits what?

Antigen presenting capacity of monocytes

28

What helps fight viral infections and inhibits proliferation of osteoblast progenitors?

interferons (IFN)

29

What activates osteoclasts?

TNF (alpha and beta)

30

Which 5 factors are Proinflammatory/destructive?

1-IL-1B
2-Tumor Necrosis factor-a (TNF-a)
3-IFN-y
4-Prostaglandin E2 (PGE2)
5-MMPs