Pathologies of liver and gall bladder Flashcards
Causes of acute liver injury
virus (hepatitis)
alcohol
drugs
bile duct obstruction
What viruses cause chronic hepatitis and cirrhosis
Hepatitis B and C
What is jaundice
Increased circulating bilirubin
Where is haemoglobin split to haem and globin
spleen
What is converted to bilirubin and where
haem
spleen
What is cholestasis
accumulation of bile on hepatocytes or canaliculi
What is primary biliary cholangitis
Auto immune disorder of the liver
cause inflammation of bile ducts which causes them to occlude
leads to cirrhosis
What is Primary Sclerosing cholangitis
chronic inflammation of bile ducts, which leads to fibrosis occlusion
What is Primary Sclerosing cholangitis associated with
inflammatory bowel disease
Difference between Primary Sclerosing cholangitis and primary biliary cholangitis
primary biliary cholangitis is granulomas
Primary Sclerosing cholangitis is fibrous
Primary Sclerosing cholangitis has a high risk of developing into what cancer
cholangiocarcinoma
What is cholangiocarcinoma
Cancer of bile duct epithelium
Excess what can cause liver cirrhosis
iron
copper
Causes of cirrhosis
alcohol
hepatitis B,C
obesity
Complications of liver cirrhosis
loos of function
portal Venous hypertension
