Pathology

Question 1

Cytosolic Caspases

Answer 1

a family of cysteine proteases that play essential roles in apoptosis, necrosis, and inflammation.

Question 2

Intrinsic pathway of Apoptosis

Answer 2

involved in tissue remodeling in embryogenesis; occurs when anti-apoptotic gf (Bcl-2) decreases and pro-apoptotic factors (Bax) increase.

Question 3

Extrinsic pathway of Apoptosis

Answer 3

Mediated by either Ligand receptor interactions: Fas ligand binding to Fas-R (CD95); or T-cell release of perforin and Granzyme B.