test Flashcards
Hope this works! (12 cards)
test
Test
test
P-glycoprotein (P-gp)
an important efflux transporter encoded by the MDR1 gene; acts as a transmembrane pump that removes substrates from membrane and cytoplasm using ATP (sometimes against high concentration gradients). Erythromycin is a substrate of P-gp; Cyclosporine A, tamoxifen can inhibit P-gp.
test
Sink
when highly lipd soluble durgs move into muscles and fat where they have no physiological activity
test
Lag time
the time from taking a drug to when it first appears in the blood
test
Time to Onset of Activity
the time from taking a drug until it starts to work (reaches minimum effective concentration)
test
Duration of action
the time during which the dose is effective in the body
test
Therapeutic range
the range of plasma concentration within which the plasma drug levels produce the maximum benefit and the least toxicity
test
Virulence factors
physical components of a microbe that contribute to its ability to cause disease
test
Pathogenic mechanisms
test
Incubation period
time needed for an infectious agent to multiply and cause disease symptoms in a host
test
Pathogenesis of infection
the overall interaction between the host and infectious agents
test
Koch’s postulates
proof that a specific microbe causes a disease (4 musts: always found in the diseased animal, can be isolated, can initiate disease in susceptible animals, & can be reisolated)
