Pathology of biliary tract Flashcards Preview

GI pathology > Pathology of biliary tract > Flashcards

Flashcards in Pathology of biliary tract Deck (21):
1

 

Desctribe Cholelithiasis

  • Gallstones- 
  • Hard stone like or gravel like material formed commonly within the gallbladder 
  • Asymptomatic 

2

What is the normal composition of bile 

  • Billirubin 
  • Bile salts
  • cholesterol micelles
  • Phospholipids

​Stored and concentrated in the gallbladder and released by CCK into second part of doudenum 

3

What is the pathogenesis of Cholesterol stones 

Q image thumb

Formed when there is an imbalance between the ratio of cholesterol and bile salts which distrub micelle formation 

4

What is the appearance of cholesterol stones

Cholesterol excess in bile 

A image thumb
5

What are the risk factors for cholesterol stones 

  • Female
  • obesity 
  • Genetics
  • Diabetes 

6

What is the pathogenesis of pigment stones 

Excess bilirubin that cannot be solubalised in bile salts

A image thumb
7

What do pigment stones look like 

A image thumb
8

Risk factors for pigment stones

Excess bilirubin due to excess breakdown of RBC -> Haemolytic anaemia 

9

What are the causes of gallstone formation 

  • Acute Cholecystiti and Chronic Cholecystitis
  • Mucocoele
  • Empyema
  • Carcinoma
  • Ascending Cholangitis
  • Obstructive Jaundice
  • Gallstone Ileus
  • Acute Pancreatitis and Chronic Pancreatitis

A image thumb
10

What is choleycysttitis 

  • Inflammation of the gallbladder 
  • Commonly associated with gallstone 
  • can present as acute or chronic 
  • Common

11

Describe acute choleyscytitis 

  • Due to gallstones obstructing outflow of bile 
  • Initially sterile but can become infected 
  • May lead to empeyma, rupture or peritonitis 
  • Formation of intense adhesion within 2-3 days - scar tissue that connects it to abdominal wall

12

What are the complications of acute cholecystitis 

  • Infection 
  • Adhesions
  • Empyema, 
  • Peritonitis 
  • Rupture 

13

What are the histophathological features of acute cholecystitis 

  • Distended gallbladder 

A image thumb
14

Describe chornic cholecystitis 

  • Obstruction of gallbladder by gallstones
  • Can be insidious or due to repeated acute cholecytitis 
  • thickening of gallbladder and adhesions
  • gallbladder is not distended 

15

What is the histopathologicall appeatance of chronic cholecystitis 

A image thumb
16

What areRokitansky-Aschoff sinuses 

Diverticular of the gallbladder which can be micro or macroscopic 

A image thumb
17

What will the clinical presentation of stones in common bile duct be 

Obstructive jaundice 

A image thumb
18

Describe carcinoma of gallbladder 

  • Rare
  • Adrenocarcinoma
  • Local invasion to liver
  • Associated with gallstone - poor prognosis 

19

Describe cholengiocarcinoma 

  • Carcinoma of bile duct
  • Adenocarcinoma arising from intraheptic bile duct epithelial cells
  • Assocation: Ulcerative cholitis and primary Sclerosing cholangitis
  • Presents with obstrutive jaundice 

A image thumb
20

What is the histological appearance of cholengiocarcinoma 

A image thumb
21