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Hematology/Oncology > Pathology of Hodgkin Lymphoma > Flashcards

Pathology of Hodgkin Lymphoma Flashcards

1
Q

What are Reed-Sternberg cells?

A

Characteristic of classic Hodgkin lymphoma, they are damaged B cells that do not express their antibody and support the growth and survival of tumor cells

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2
Q

Reed-Sternberg cells are positive for what markers?

A

CD15+, CD30+, PAX5+

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3
Q

Non-classic Hodgkin lymphoma does not present with Reed-Sternberg cells. What cells are present?

A

L&H (popcorn cell)

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4
Q

Hodgkin lymphoma arises from what cell type?

A

B cells

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5
Q

This type of Hodgkin lymphoma has fibrous bands, nodules, and lacunar “lake-like” RS cells.

A

Nodular Sclerosis

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6
Q

How does Hodgkin and non-Hodgkin lymphoma differ?

A
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7
Q

This type of classic Hodgkin lymphoma is dominated by T cells, with few RS cells present.

A

Lymphocyte-Rich

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8
Q

What are the characteristic “B symptoms?”

A

Fever, night sweats, weight loss

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9
Q

This is a type of Lanergans Cell Histiocytosis that presents in young children with calvarial bone defects, diabetes insipidus, and exophthalmos (protruding eyes).

A

Hand-Schuller-Christian Disease

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10
Q

This is the least common type of classic Hodgkin lymphoma, primarily presenting with RS cells, necrosis, and fibrosis.

A

Lymphocyte-Depleted

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11
Q

Diagnosis with what type of Hodgkin Lymphoma confers the best prognosis?

A

Nodular sclerosis

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12
Q

What transcription factor is activated in Hodgkin lymphoma?

A

NF-kB

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13
Q

What proteins are expressed by Langerhans cells?

A

S-100 protein and CD1a

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14
Q

True/False. Flow cytometry is generally not useful for diagnosing Hodgkin lymphoma.

A

True - neoplastic cells are in the minority

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15
Q

These cells are described as having an “owl eye” appearance.

A

Reed-Sternberg Cells

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16
Q

This cell type is morphologically characteristic of Hodgkin lymphoma.

A

Reed-Sternberg cells

17
Q

This is the second-most common type of classic Hodgkin lymphoma, with biphasic age presentation and often EBV+.

A

Mixed Cellularity

18
Q

True/False. Classical Hodgkin lymphoma is CD45-, while non-classical Hodgkin Lymphoma is CD45+.

A

True

19
Q

Non-classical Hodgkin Lymphoma has L&H “popcorn cells.” What is the IHC stain profile?

A

CD20+, CD15-. CD30-

20
Q

When does Hodgkin lymphoma generally present?

A

20-40yo

21
Q

This type of Hodgkin lymphoma presents with scattered neoplastic cells in follicles of dendritic cells and lymphocytes.

A

Nodular Lymphocyte Predominant Hodgkin Lymphoma (Non-Classical)

Hematology/Oncology (18 decks)

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