Pathoma Carcinogens Flashcards

1
Q

What cancer(s) is associated with Aflatoxins?

A

Hepatocellular Carcinoma

most common cancer in some African countries
(rice and grains)

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2
Q

What cancer(s) is associated with Alkylating Agents

A

Leukemia/lymphoma

side effect of chemotherapy

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3
Q

What cancer(s) is associated with Alchohol?

A

1) squamous cell carcinoma of oropharynx and upper esophagus
2) hepatocellular carcinoma
3) pancreatic carcinoma

(chronic pancreatitis: common side effect is pancreatic carcinoma)

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4
Q

What cancer(s) is associated with Arsenic?

A

1) squamous cell carcinoma of skin
2) lung cancer
3) angiosarcoma of liver

(arsenic present in cigarrete smoke)

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5
Q

What cancer(s) is associated with Asbestos?

A

1) Lung carcinoma
2) mesothelioma

(asbestos exposure more likely to cause lung cancer than mesothelioma)

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6
Q

What cancer(s) is associated with cigarette smoke?

A

carcinoma of oropharynx, esophagus, lung, kidney, bladder, and pancreas

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7
Q

What component of cigarette smoke is particularly carcinogenic?

A

polycyclic hydrocarbons

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8
Q

What cancer(s) is associated with Nitrosamines?

A

Stomach carcionoma

found in smoke foods- high rate stomach carcinoma in Japan

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9
Q

What cancer(s) is associated with Napthylamine?

A

Urothelial carcinoma of bladder

derived from cigarrete smoke

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10
Q

What cancer(s) is associated with Vinyl Chloride?

A

Angiosarcoma of liver

used to make PVC for pipes

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11
Q

What cancer(s) is associated with Nickel, chromium, beryllium, or silica?

A

Lung carcinoma

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12
Q

What cancer(s) is associated with EBV?

A

1) Nasopharyngeal carcinoma
2) Burkitt lymphoma
3) CNS lymphoma in AIDS

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13
Q

What cancer(s) is associated with HHV-8?

A

Kaposi sarcoma

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14
Q

What cancer(s) is associated with HBV and HCV?

A

Hepatocellular Carcinoma

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15
Q

What cancer(s) is associated with HTLV-1?

A

Adult T-cell leukemia/lymphoma

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16
Q

What cancer(s) is associated with High risk HPV (subtypes 16, 18, 31, 33)?

A

1) squamous cell carcinoma of vulva, vagina, anus, and cervix
2) adenocarcinoma of cervix

17
Q

What cancer(s) is associated with Ionizing radiation?

A

1) AML
2) CML
3) papillary carcinoma of the thyroid

18
Q

What cancer(s) is associated with Non-Ionizing radiation (ie UVB sunlight)?

A

1) Basal Cell Carcinoma
2) squamous Cell Carcinoma
3) Melanoma of skin

(non-ionizing radiation results in formation of pyrimidine dimers in DNA)