Pathoma Oncogenes and Associated Tumors

Question 1

Function and Associated Tumor for PDGFB?

Answer 1

• platelet derivered growth factor

- Astrocytoma

Question 2

Function and Associated Tumor for ERBB2( HER2/neu)?

Answer 2

• Epidermal growth factor receptor

- Subset of breast carcinomas

Question 3

Function and Associated Tumor for RET?

Answer 3

• neural growth factor receptor

- MEN 2A, MEN 2B, sporadic medullary carcinoma of thyroid

Question 4

Function and Associated Tumor for KIT?

Answer 4

• Stem Cell Growth Factor Receptor

- Gastrointestinal stromal tumor

Question 5

Function and Associated Tumor for RAS gene family?

Answer 5

• GTP-binding protein

- carcinomas, melanoma, and lymphoma

Question 6

Function and Associated Tumor for ABL?

Answer 6

• Tyrosine kinase
• CML and some types of ALL

mechanism: t(9;22) with BCR

Question 7

Function and Associated Tumor for c-MYC

Answer 7

• transcription factor
• Burkitt lymphoma (lymphoma of B cells; starry sky appearance)

mechanism: t(8;14) involving IgH

Question 8

Function and Associated Tumor for N-MYC

Answer 8

• transcription factor
• Neuroblastoma

“N for neuroblastoma”

Question 9

Function and Associated Tumor for L-MYC

Answer 9

transcription factor- Lung Carcinoma (small cell)

Question 10

Function and Associated Tumor for CCND1 (cyclin D1)

Answer 10

• cyclin (cell cycle regulator)
• Mantle Cell lymphoma

mechanism: t(11;14) involving IgH

Question 11

Function and Associated Tumor for CDK4

Answer 11

• cyclin-dependent kinase

- Melanoma