Pathophys II- Myeloid disease

Question 1

Left shift=

Answer 1

Appearance of immature neutrophils granulocytes in the periphery

Question 2

Leukemoid reaction is caused by

Answer 2

Severe infection

Question 3

Which cell can we see in acute leukemia?

Answer 3

Excess of blast cells

Question 4

In AML, we will see how many blast cells?

Answer 4

More than 20%in bone marrow and in periphery

Question 5

% of blast cells in bone marrow of healthy person

Answer 5

5%

Question 6

Number of blast cells in periphery of healthy person

Answer 6

0

Question 7

__ of acute leukemia are ___ in adults

Answer 7

80%

AML

Question 8

__ is more dominant in kids (AL)

Answer 8

ALL

Question 9

Laboratory of AML

Answer 9

Uric acid ↑

LDH ↑

Question 10

Immunophenotyping

Answer 10

CD33+
CD34+
CD117+
CD13+
CD15+

Question 11

How tho differentiate btw lymphoblast and myeloblast on a smear?

Answer 11

Myeloblast have more cytoplasm

Question 12

Myeloproliferative syndrom examples

Answer 12

CML
PV
ET
Idiopathic myelofibrosis

Question 13

___ of all leukemia are CML

Answer 13

15%

Question 14

CML is most common in __ age

Answer 14

50-70 years

Question 15

What is a philadelphia chromosome

Answer 15

chr 22 that got a new piece from chr 9

Question 16

philadelphia chromosome creates

Answer 16

bcr-abl fusion gene

Question 17

bcr-abl fusion gene creates

Answer 17

Tyrosine-kinase

Question 18

What is the problem with bcr-abl Tyrosine-kinase

Answer 18

Continously stimulates proliferation and inhibits apoptosis

Question 19

Blast crisis will develope after ___ years

Answer 19

3-5 years

Question 20

Blast crisis happens after which phase

Answer 20

Accelerated phase

Question 21

CML peripheral blood smear

Answer 21

All stages of differetiation of granulocytic cell line are present

Question 22

CML therapy

Answer 22

Tyrosine kinase inhibitors

Imatinib-gleevec

Question 23

Blood film of thrombocytosis

Answer 23

> 600 G/L

Question 24

Genetic test in ET

Answer 24

JAK2-V617F

in 50% of ET

Question 25

Treatment in ET

Answer 25

IFN-a

Question 26

IFN-a function

Answer 26

Inhibits Thrombopoiesis

Question 27

C. Difficile positive lady shows on blood test

Answer 27

Neutrophilia

Left shift

Question 28

C. Difficile positive lady is diagnosed with

Answer 28

Clostridium difficilr assosiated disease

Question 29

Plethoric complexion means

Answer 29

Red faced

Question 30

Uric acid is a bi product of ____

Answer 30

Purine metabolism

Question 31

Acrocyanosis=

Answer 31

Hypoxia of hands and feets

Question 32

How can we confirm Polycythemia

Answer 32

JAK-2 mutation

Question 33

How can we trear PV

Answer 33

Give IFN-a to supress bone marrow

Question 34

We need to differentiate PV into

Answer 34

Primary

Secondary

Question 35

ET PLT count

Answer 35

> 600 G/L

Question 36

Blast ration in AML

Answer 36

> 20%

Question 37

AML. Whic CD cells do we expect to find?

Answer 37

CD33
CD34
CD13
CD117

Question 38

Cmmon alteration in AML in chromosome

Answer 38

11q13 MLL gene alteration

Question 39

MLL gene alteration acounts for __ of AML

Answer 39

7%

Question 40

Where can we find BCR-ABL fusion gene?

Answer 40

CML

Question 41

How can we treat CML?

Answer 41

Imatinib- Tyrosine Kinase inhibitor

Question 42

Women with C.Difficile.

What does she have?

Answer 42

C.Difficile assosiated disease

Question 43

Patient with thick blood+she is a smoker

Answer 43

Polycythema.

Can be primary due to smoking

Question 44

A patient is diagnosed with Thrombocytemia.

What should we check next?

Answer 44

Primary- ET (JAK2 mutation)

Secondary- Malignancy….Check TPO levels, Splenectomy