Pathophysiology of Thyroid Medications Exam 1 Flashcards
1
Q
What are the lab markers used to assess thyroid function?
A
- TSH
- Free T4 (FT4)
- Total T4 (TT4)
- Total T3 (TT3)
2
Q
What is the normal lab range for TSH?
A
0.4-4.7 mIU/L
3
Q
Why are TSH lab values important?
A
used to evaluate thyroid function and therapy because of its sensitivity
4
Q
What is the most common cause of hyperthyroidism?
A
Grave’s Disease
5
Q
What are the clinical presentations of Grave’s disease?
A
- Exophthalmos (big bulging eyes)
- Thyroid gland enlargement (2-3x normal)
- Pretibial myxedema
6
Q
What is a common cause of Grave’s disease?
A
Thyroid stimulating antibodies are directed against the thyrotropin receptor on the surface of the thyroid cell overproducing thyroid hormone
7
Q
What is the most common cause of hypothyroidism?
A
Hashimoto’s Disease
8
Q
What is a common cause of Hashimoto’s?
A
- Immune system attacks thyroid which then becomes inflamed leading to underactive thyroid
- Cell and antibody mediated thyroid injury leading to B lymphocyte stimulation and production of thyroid antibodies
9
Q
What are the clinical presentations of Hashimoto’s disease?
A
- Goitrous thyroid gland enlargement and mild hypothyroidism
- Thyroid gland atrophy
- Severe thyroid deficiency
