Peads oncology presentation

Question 1

Most common paediatric malignancies?

Answer 1

leukaemia’s
CNS
lymphoma
soft tissue sarcoma

Question 2

When does a wills tumor present?

Answer 2

<1 yo

Question 3

what brain malignancy present specifically in <3 yo?

Answer 3

ependymoma

choroid plexus Ca

Question 4

What brain malignancy covers age groups 0-22?

Answer 4

medulla plastoma
Astrocytoma
cerebellar astro.

Question 5

What dd for head back cancer?

Answer 5

NB
RMS
lymphoma

Question 6

What predisposition syndrome cause cancer in kids?

Answer 6

Retinoblastoma 
Li-fraumeni 
NF 1/2
AT
FA

Question 7

What dx for horners syndrome?

Answer 7

NB

Question 8

What dx for SVC obstruction

Answer 8

NHL

Question 9

What dx for proptosis?

Answer 9

NB and RMS

Question 10

What dx fora pathological fracture?

Answer 10

Osteosarcoma

Ewigs sarcoma

Question 11

What dx for rashes

Answer 11

Hodkins

LCH - langerhans cell histiocytosis

Question 12

What dx for night sweats?

Answer 12

lymphomas

Question 13

What paediatric tumours cause hepatomegaly?

Answer 13

leukaemia
NB
Hepatoblastoma
mets

Question 14

What paediatric tumours cause splenomegaly?

Answer 14

leukaemia

MDS

Question 15

Rule of thumb… which signifies cancer, speno- or hepatospenomegaly?

Answer 15

Splenomegaly indicates tumour

Question 16

What peadiatric tumours cause pelvic tumour

Answer 16

Rhabdos
Ovarian - teratoma, GC
sacrococcygeal teratomas

Question 17

What Sx of infra-tectorial tumours?

Answer 17

CN palsies = brainstem 
CN VI (flash localising, failure = brainstemm)
Ataxia and co-ordination

Question 18

What Sx of supra-tectorial tumours?

Answer 18

Raised ICP 
seizure 
UMN signs 
visual field defects 
diencephalic syndrome (hypothalamus)

Question 19

Ddx x-ray limb.

Answer 19

Osteomsarcoma
Ewings
Langerhan’s cell histiocytosis

Question 20

Spot diagnosis: punched out lesions in skull?

Answer 20

Langerhan’s cell histiocytosis

Question 21

Investigations of bone marrow aspirate shows dx of…

Answer 21

NB
RMS
lymphoma

Question 22

Investigations of LP aspirate shows dx of…

Answer 22

lymphoma

some bone tumours

Question 23

What can a MIBG scan help detect?

Answer 23

NB

Question 24

What can a urinary catecholamines help detect?

Answer 24

NB phaeos

Question 25

What are negative prognostic markers?

Answer 25

MCYN copy number 1p deletion Gain of 17q

Question 26

What ChT affects lung function?

Answer 26

bleomycin

Question 27

Which tumours have a roll for ChT in delaying radiotherapy?

Answer 27

medulloblastoma GCT gliomas

Question 28

Why is asparaginase used in ALL?

Answer 28

depletes asparagine, which lymphoma cannot synthesis, therefore limiting growth.

Question 29

What function of age affects the prognosis of NB?

Answer 29

<1 yo - good survival | >2yo - poor survival