PED1003/L01 Intro to Drug Action Flashcards
Define pharmacology.
What the drug does to the body
What the body does to the drug
Where do drugs typically come from? (2)
Plants or fungi
Where is aspirin derived from?
Willow tree bark
Where is morphine derived from?
Opium poppy
Where is psilocybin derived from?
‘Magic’ mushroom
How are synthetic drugs created in the laboratory? (3)
Novel medicinal chemistry
Identical to natural compounds (mimics)
Derived from natural compounds
Define pharmacodynamics.
The effect of the drug on the body
What molecular interactions does pharmacodynamics focus on? (3)
Targets for drug action
How drugs act at target
How drug produces action within cell
How is the influence of drug concentration on magnitude of response shown?
Graphically with dose-effect relationships
What does study of pharmacodynamics allow?
Determine appropriate dose range for patients
Compare efficacy and safety of one drug to another
What is the distance between 2 lines on a dose-response curve called?
Therapeutic window
Define pharmacokinetics.
The effect of the body on the drug
Give the phases involved in pharmacokinetics. (4)
Absorption into blood
Distribution into ICF and ECFs of tissues
Metabolism - inactivation through enzymes
Excretion through urine, bile or faeces
What does study of pharmacokinetics allow? (3)
Determination of:
Route of administration
Frequency of dosing
Treatment duration
Give 3 other considerations of drugs.
Hydrophobicity
Ionisation of drug (pKa)
Conformation of target
Stereochemistry of drug
