Pediatric Fevers Flashcards

1
Q

Define a Fever
rectal body temp on who

A

Fever
- adapative temp regualtion response (no hyperthermia; which is conditions that overwhelmt he normal thermoreg. process)

normal rectal temp = 97-100 degress

infants: 0-56 days (8weeks) = 100.4 or 38C = fever
children 56+ days = 101.3 or 38.5C = fever

rectal temp MUST be obtained for those under 3months, often gotten for all kids under 2 years

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2
Q

who is considered a compromised host for a fever pt

A
  • those under 56 days
  • those with recent surgery
  • those with internal deviceshardware
  • immunodeficeint (primary or secondary to treatment)

in these pt…
- need to add testing
- rapid abx use
- stress dose steroids

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3
Q

Symptoms and Signs of a Fever in Kids

A

SYmptoms/Signs
- irratibility
- inconsoable crying
- lackk of appetite
- seeking mom (warm)
- sittign near warm objects and blanekts
- refusing cold things
- interacting less
- febrile seizure risk

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4
Q

Signs of Severe Disease in kids iwth fever

A

Toxic Appearing
- irraiblte
- non-interactive
- poor perfusion

meningitis/ecenphaitis
- altered sensorium: irriatbility, legthargic, obstuned or coma
- neuro signs: seizures, meningismusm, focal nero issues
- icp elevated: buldging fontelle, vomiting
- remebre infants under 1 may not show signs of meningismus

Upper airway
- eppiglottois: tripoding, drooling, extended neck
- croup: suprasternal retractions, stridor
- deep neck infection: dec. ROM neck, unilater swelling in nec/mouth

PNA
- fever + respirtaory sx. 3-4 days with hypoxia and tachypnea

bronchilotilits
- secretions

severe PNA, mycarditis, sepsis
- AMS
- tachypnea, tachycardia
- poor perfusion
- cyanosis
- heaptmeg.

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5
Q

Severe infections + fever

RMSF
menigiococcemia
sepsis syndrome

vs.

nec. fasc.

A

signs of these
- anxious, AMS, irratible
- petechail, purpura rash = errythema

Necrotizing fasciitis
- severe pain out of proportion to exam
- skin cahnges
- sepsis and rapid progression

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6
Q

Febrile Neonate: 0-56 days
what are some red flags

A

Febrile Neonate
- fever > 100.4 or 38C
- theyre at increased risk for infections and sequale of infections

Red Flags
- AMS: low tone, limp, weak cry
- buldged fontelle (meningitis)
- poor perfusion
- respiratory distress
- toxic? do sepsis workup

important history points
- tmax
- oral intake an durine output
- birth history
- moms HSV and GBS risk
- newborn screen results

PE findings with fever
- vitasl, wegiht
- looks for infection in eyes and ears
- cardiac
- neuro: tone and responsiveness
- skin: mottling is a sking of fever
- abd. omphalitils: infection ofo umbilical

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7
Q

Febrile Neonate: 0-56 days
HSV suspicion

A

HSV
- testing for all those 21 days and younger
- always considered moms risk of having it too

Testing
- CSF and serum HSV PCr
- unroof a vesicle and swab for HSV PCR

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8
Q

Febrile Infant
workup for those 0-21 days
for those 22-28 days
29-56 days

A

Workup 0-21
- POC gluocse
- CBC with diff, cultures
- CMP/BMP, HSV if needed
- UA and culutre (catheter is better)
- LP everyone under 21 days: csf from gram stain,culutre, protein, glucose, cell count and HSV

workup: 21-28 days
- decision for LP decided on by tha abnormal inflmmatory markers (procalcitonin) OR the UA results
- can admit and obs. - wait for culutres, etc. then decide on LP

workup: 29-56 days
- those with 1+ abnormal inflammatory marker = LP
- abnormal UA and abnormal infalmmatory = consider LP

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9
Q

Febrile Infant
but well appearing with no CSF finding

Treament
0-21 days
22-28 days
29-56 days

A

WELL APPEARING: NO CSF PLEOCYTOSIS

0-21 days
- ampicillin
- ceftazidime
- acyclovir

22-28 days = abnormal UA/inflams.
- ampucillin
- ceftazadime
- +/- acyclovir

29-56 days = abnormal inflams. normal UA
- ceftriaxone

29-56 days = abnormal UA
- ceftriaxone
- ampucillin
- +/- acyclovir

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10
Q

Febrile Infant: Ill Appearing OR CSF +
treatment
0-21 days
22-28 days
29-56 days

A

ILL APPEARING or CSF POSITIVE

0-21 days
- vancomycine
- cefepime
- acyclovir

22-28 days
- vancomycin
- cefepime
- +/- acyclovir

29-56 days
- vancomycine
- ceftriaxone
- +/- acyclovir

for those with risk of meningitis, under 28 days you cant used ceftriazone (bili issue) = so use cefepime instead
and give everyone vancyomycin to cover MRSA

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11
Q

meds to consider for those age 0-28 days

A

ampicillin = can be used for GBS and listera

Cetazadime = good for this age gropu
- doesnt penitrate CNS or cover MSSA

Ceftriazone = to be avoided

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12
Q

meds to consider in those 29-56 days

A

ceftriaxone
- can be used in this age
- GBS , strep penumniae, streptocuccos and enterobacterales

is you suspect enterococcus: ampicillin should be added

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13
Q

Postive UA results in peds. fever

postive blood culutres

postivie CSF

Positive HSV

A

Postive UA + culutre
target te abx to specific specices
RBUS: to look for abnoralities
can consider LP and empiric abx.

Postive Blood Culture
- repeat blood culutre prior to adjusting abx.
- consider broad coverage if pending results
- perform Lp and start abx. if not already done

Postivie CSF
- ensure meningitic dosing
- consult ID for broad coverage

Positive HSV
- consult ID and acyclovir duration

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14
Q

Criteria to discharge the febrile infant

A
  • negative culutres
  • well-appearing PO feeding
  • D/C after 24 hours if CSF WBC is interpretable + negative
  • D/C after 36 hours if unable to interpret CSF
  • follow up wit hPCP in 72 hours
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15
Q

Sepsis in the Febrile Ped Pt.
criteria

A

Criteria for Sepsis

any of the following
- temperature fever or hypothermia (under 36)
- heart rate abnormality

PLUS
- mental status abnormality (crying, drowsy, restlenss, obtunded)
- perfusion abnormality (cool extremities, mottling, delayed cap. refill OR warm, flushed, flash cap refill,boudning pulses)
- hypotension
- tachypnea

= sepsis

________________________ other findings (organ dysfunction)

lab findings: metabolic acidosis, elevated lactae, low platelets, coag issues

PE findings: rash, erythroderma

high risk: under 60 days old, central line, immunocomp., preexisintg neuro condition

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16
Q

after determining sepsis, what is the initial mangement

A

Sepsis determined
- iv access and labs drawn
- fluid resusication : NS or LR
- abx. within 60-180 minutes
- reasses Q15min, MS, WOB, perfusion adn vitals
- correct hypoglycemia or hypocalcemina
- if unresponsive to fluids, initaition of vasopressors

17
Q

Kawasaki Disease
when to conisder this with fever in peds

A

KD in…
- those with fever 3+ days and any features of KD (CREAM)

OR

  • infants under 6 months with 7+ days of the unexplained fever

Clinical Features
- mucositis: starwberry tongue
- conjunctivitis: bilater injection without exudate and spares limbus
- rash: maculopap.
- lymphadenopathy
- extermities: desquam of palms and soles

Diagnosis made when…
fever 5+ days AND 4+ symptoms
or
fever 4+ days with all 5 features

18
Q

MIS-C in peds.

A

MIS-C
multisystem inflammatory syndrome in children

etiology
- a syndrome that results from COVID: abnormal immune response with simialr features to KD but its due to covid realted immune reaction
- macrophage activaition and cytokine release

Symptoms
- rash: nonpustualr
- GI SYMPTOMS: diarrhea,abd pain and vomiting
- extremitiy cahnges : red and sweollen
- oral mucosa: cracking lips, starbweery tongue
- conjuntivitis: can involve limbus and no exudates
- lmpyh invovlement
- NEUROLOGIC SYMPTOMS: HA, irratibilty, AMS, neck stiffness, CN palsy

19
Q

MIS-C
diagnosis

A

Diagnosis
-fever 3+ days
- symptoms of MIS-C 2+

labs
- cbc, cmp, crp, esr
- low Na+
- low lymphocytes
- low platelets

CRP > 3 or ESR >40 PLUS 1 of the following
- lymphopenia < 1k
- thrombocytopenia < 150k
- Na < 135
- abnormal creatinine for age

Treatment
- inpt. to PICU : monitor for shock

20
Q

definition for
fever in immunocmp.

fever of uknonw origin

A

fever in immunocomp.
- fever 1x > 38.5
- fever 38 x 3times within 24 hours 1 hour apart

fever FUO
- fever daily > 38.5 for > 8 days

21
Q

Febrile Seizures
who/etiology
simple v complex

A

Febrile Seizures
- age 6 months - 6 years most commonly
- occational family hx.

whos at risk of epilessy
- those with neurodevelopment sisues
- complex febrile seizures with focal onset
- febrile stats epi.
- family history

simple
- brief < 15 minutes
- general seizure
- no more thatn 1 in 24 hours
- assocatied with fever 38.4+

complex (defined by any 1 of the following)
- prolonged (more than 15 mins.)
- focal onset (starting at one place)
- recurrent: 1+ in 24 hours

22
Q

febrile seizure
workup

A

Workup
- consider meningits!!!

LP consideration
- < 6 months : needs it
- 6-12 months: considere if not immunized to hib or pnumo.
- 12 months + : only if clincial conerns

labs
- glucose
- cbc, cmp, mag, phos,

imaging
CT/MRI = not for simple, yes for febrile status epilepticus

EEG: not for simple, could consider for complex, esp if focal onset

genetic testing: not for simple, conbe

23
Q

Febrile Seizure
management
status epileticus

A

anti-pyretic do not prevent recurrent febrile seizures

continuous seziure meds are not recommended: rarely keppra used; recurrent can use dizapem rectal

cold baths not recommened

status epilepticus
- 5+ minutes of continuous seizure or EEG activity of seizure without retunr ot baseline
- prolong > 30-60 minutes resuls in neuronal injury

Treament = lorazepam, then lorazapam, then keppra!! in 5 minute intervals

24
Q

FIRES syndrome

A

FIRES
- febrile infection related epilepsy syndreom
- subset or NORSE: clincal presentaion plust hx. of epilepsy with refractory status

FIRES
- priorhistory of febriles infection
- fever between 2-2 wweeks priot to the onset of teh status epi.

treament: phenobarb, ketamine or midazoplam coma induction