Pediatrics Flashcards

1
Q

Children’s concepts of death table

A
  • Infancy 0-2 years
    • sensory information
    • estsablishing attachment
    • aware of tension, unfamiliar, separation
    • distressed by disruptions in routine
    • comforted by sensory input (rocking, sucking, transitional object) and routines
  • Early childhood (2-6 years)
    • death is reversible, not personalized, magical thinking, associative logic
    • may not believe death can happen to them, believe can cause death by wishing someone would go away
    • provide concrete info about being dead
    • address guilt and feeling repsonsible because of thoughts
  • Middle childhood (6-12 years)
    • mastering skills, fairness, cause and effect
    • aware death is final, personalized
    • understanding causality by external and internal causes
    • aware that death can be caused by accident, illness
    • may have difficulty with spiritual/abstract
    • Child may request graphic details about death and illness
  • Adolescence (> 12 years)
    • working on separation, individuation, identity formation
    • universality of death, but distanced from it
    • risky behaviour (everyone dies anyways, it can’t happen to me)
    • access to supportive peers
    • may need to talk about plans that will not be realized (school, marriage, kids, career, etc)
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2
Q

List elements of sharing information about serious illness and death with children

A
  • Explore how family communicates
  • Find out HOW the family wishes information would be shared
  • Do not talk to the children for the family. Assist.
  • Use honest, gentle, simple language
  • Let the child guide you
  • Explore beliefs of child and family
  • Be aware of your own beliefs (and differences)
  • Reflect on emotions of child
  • Work to support child and family in what is important to them
  • Clarify child’s understanding in a non-testing way
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3
Q

How can a family member speak to a child without crying?

A
  • expression of emotion and grief normalizes feelings
  • should not be so intense that child needs to comfort adult
  • provide developmentally appropriate toys and play activities
  • talk about favourite toys, shows, etc as introduction
  • children may draw picture or used stuffed toys to express emotions
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4
Q

Supportive measures for helping child through serious illness/ death

A
  • Help families find language to use, developmentally appropriate concepts
  • Misinformation leads to confusion and fear. Be honest
  • Use videos, books, websites
  • Support children in their play as it is often combined with grief.
  • Share information paced according to needs
  • Arrange environment to be welcoming and accessible to child
  • support person for child
  • Allow child to ask for what they need, listen to them and follow their lead
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5
Q

Language tips for talking with children about death

A
  • “He may look like he is sleeping, but being dead is very different than sleeping”
  • “Dead means that a person’s heart isnt beating any more, they don’t need to eat anymore, they aren’t hungry or thirsty anymore, they don’t breathe anymore…”
  • Use the words dead and death (unless sig cultural exceptions)
  • Why? “Your sister died because she was born with something very wrong with her lungs that could not be fixed”
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6
Q

Involving children at the time of death

A
  • Children do better if involved in care of dying family member
  • Support person (child life, volunteer. etc)
  • Prepare them for what room and person will look like
  • Let them know they can talk to their family member
  • Ideas for ways child can say I love you.
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7
Q

Children’s guilt

A
  • Be aware of magical thinking
  • Children can think they are responsible for death of family member because they wished they would go away
  • Particular problem if child was bone marrow or organ donor
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8
Q

Should children attend a funeral?

A
  • do better if included in family rituals
  • sadness is permissable, alright to cry, feel safe with own feelings
  • Prepare child
  • Give them details
  • explain whether there will be a coffin
  • simple language
  • answer questions
  • ask someone child trusts to accompany them
  • allow child to choose whether to attend funeral or not
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9
Q

Pain and Symptom Assessment in Children : principles similar to adults and unique to children

A
  • 0-10 scale understood by 7-8year olds
  • Faces Pain Scale - revised
  • Behavioral observations of child by parents, health professionals

Principles similar to adults

  • anticipate and prevent pain
  • provide ATC meds
  • oral route first
  • IR for breakthrough
  • titrate to pain relief
  • anticipate and prevent adverse effects
  • use adjuvants
  • never limit opioids out of fear of constipation

Principles different to adults

  • do not ignore or under treat pain in children
  • non specific symptoms for pain (irritable, withdrawn etc)
  • use pain scales for patient’s developmental stage
  • Medical condition may affect pain assessment (cerebral palsy and facial grimacing)
  • less likely to express specifics about pain
  • IV > sc route as many kids already have access
  • child may lack understanding of cause-effect relationship
  • opioid rotations more common (instead of adding meds to manage Se of opioid)
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10
Q

Pharmacokinetics and pharmacodynamics:

differences in children

A
  • mg/kg
  • non ventilated infants, dose is 1/3 usual dose and titrated.
  • infants higher risk of opioid toxicity because of higher surface area, incr fat-muscle ratio, decreased glycoproteins, decreased renal and hepatic clearance
  • many medications not studied in children
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11
Q

Fears and facts about pain medications in children

A
  • address msiconceptions and fears with caregivers
  • medications won’t impair ability to interact and play
  • uncontrolled pain will impair ability to interact and play
  • children not at increased risk of adverse effects
  • not at increased risk for addiction
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12
Q

What is the most common cause of pain in children with cancer, compared to adults

A
  • procedures and treatment related interventions
  • vs adults : disease related pain
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13
Q

Checklist for analgesic therapy in children

A
  • pain relief at lowest effective dose
  • anticipate, prevent and treat side effects
  • use ATC dosing
  • Dosing:
    • oral preferred or use port
    • equianalgesic dose (oral: iv)
    • ensure preparation is suitable to child (taste, frequency, etc)
    • avoid IM, rectal
    • no transdermal fentanyl if opioid naive
    • no demerol, no mixed agonist-antagonists meds
    • no codeine (metabolism)
    • use topical anesthetics before needles
  • Use analgesic to match pain
    • acetaminophen mild
    • Codeine - controversial for mild-moderate
    • hydromorphone, morphine. diamorphone for moderate-severe pain
  • Review pharmacokinetics
    • < 50kg - mg/kg
    • > 50 kg - usual adult dose
    • non ventilated infants < 6 months, use 1/3 - 1/4 usual starting dose
  • Start with IR dose
  • Change to SR formulation once requirements are known
  • Breakthrough analgesia q1h (10% MEDD). If> 4 BTD used in 24 h, increase ATC dose
  • Bowel routine
  • Adjuvant analgesics (gabapentin, steroids, TCA, ketamine)
  • Use non pharm things (massage, tens, distraction, hynotherapy)
  • Reassure family more options available
  • Proactively address misperceptions, concerns
  • Child is reliant on another for analgesia
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14
Q

Pediatric Opioid dosing

A
  • Morphine ORAL (3:1)
    • < 50 kg : 0.15-0.3 mg/kg q4h
    • > 50 kg : 5-10 mg q4h
  • Morphine IV/SC
    • < 50 kg : 0.05-0.1 mg/kg q4h
    • > 50 kg 2.5-5 mg q4h
  • Hydromorphone ORAL (1:3- 1:5)
    • < 50 kg 0.06 mg/kg q4h
    • > 50kg 1-2mg po q4h
  • Hydromorphone IV/SC
    • < 50 kg 0.015 mg/kg q4h
    • > 50 kg 1 mg q4h
  • Codeine ORAL (1:1.5)
    • < 50 kg 0.5-1mg/kg
    • > 50 kg 30-60 mg q4h
  • Codeine IV/SC
    • < 50 kg: 0.5 mg / kg q4h
    • > 50 kg: 15-60 mg q4h
  • Oxycodone ORAL
    • < 50 kg : 0.2 mg/kg q4h
    • > 50 kg : 5-10 mg q4h
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15
Q

Dyspnea in pediatrics

A
  • cancer
  • cystic fibrosis
  • muscular dystrophy
  • spinal muscular atrophy
  • cerebral palsy with infections
  • congenital heart disease
  • metabolic storage disease
  • neurodegenerative disease
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16
Q

Measurement / Assessment of dyspnea

A
  • Are you a little or a lot breathless?
  • Can you show my how breathless you feel? (VAS)
  • What can you do / not do because your breathlessness is bothering you?
  • Dalhousie Dyspnea Scale (effort, constriction, throat tightness) > 8 years
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17
Q

Non Pharmcological Treatment of Dyspnea

A
  • cold facecloth
  • fan
  • scent
  • positioning
    • child may not be able to position themselves (infant, CP, SMA)
    • bad side down for effusion
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18
Q

Pharmacological treatment of dyspnea

A
  • Opioids
  • Benzodiazepine
  • sedation
  • advise family that medications won’t change appearance or pattern of breathing
  • secretions treat for family
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19
Q

How are children different than adults wrt palliative care?

A
  • Different disease type and longer trajectory (60% non malignant)
    • congenital, genetic, neuromuscular, respiratory, cancer, GI
    • high prev cognitive impairment
    • HIV AIDS
  • Communciation
    • verbal, non verbal and cognitive impairment
  • Complexity of ethical dilemmas
    • cannot consent, but can assent
  • Drug dosing
    • not tested or approved for kids
    • mg/kg dosing
    • drug clearance
    • surface area of child
    • delivery mode
  • Children depend on proxy for medications and assessment
    • situational, cultural and family role impact this.
  • Role of family in peds is different
    • long term nature of illness, heavy burden
    • ++ support needed for families
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20
Q

List factors that impact pain in peds

A
  • Cognitive:
    • understanding
    • control
    • expectations
  • Behavioural
    • overt actions
    • parent/staff response
    • physical restraint
    • physical activities
    • social activities
  • Emotional
    • anxiety
    • fear
    • frustration
    • anger
    • depression

All influenced by :

  • age
  • developmental level
  • previous pain experience
  • culture
  • family learning
  • gender
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21
Q

Myths in pain in children :

Newborns do not experience pain, do not have mature nervous system

A
  • 26 weeks in utero fetus can feel pain
  • newborn is highly sensitive to pain
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22
Q

Myths in pain in children:

Children do not feel as much pain as adults

A
  • as much or more than adults
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23
Q

Myths in pain in children: Children will get used to pain. They will have no memory of it, or lasting effect

A
  • Continuing pain has long lasting effects on CNS
  • permanent reorganization of neural pathways
  • negative impact on future pain experiences
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24
Q

Myths in pain in children: Children cannot explain pain reliably

A
  • 20 months can say where it hurts, how much, and what makes it better
  • Pain intensity at 3 years
  • 4 years can indicate on body chart
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25
Q

Myths in pain : If a child is distracted, they are not in pain

A
  • Distraction and play is a coping mechanism for pain
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26
Q

Myths in pain : If a child says he is in pain, but does not appear in pain, they do not need medications

A
  • The child is the authority on whether they are in pain
  • adults under-rate pain
  • adults often have concerns that children exaggerate pain
  • Adults diminish importance of pain in kids
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27
Q

Myths in pain : A sleeping child is a comfortable child

A
  • Sleep may be from exhaustion from pain
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28
Q

Myths in pain : Opioids are dangerous for children and may result in addiction

A
  • Invaluable for pain relief in kids
  • children no more at risk for addiction than adults
  • addictions not experienced in patients with true pai on therapeutic doses
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29
Q

Impact of child’s pain on parents

A
  • parents are experts in their children
  • parents who encourage kids to engage in normal activities have better pain control
  • losing normal environment, isolation –> more pain
  • parental education of pain and management important
  • parents who respond to pain with calm approach usually have kids with better controlled pain
30
Q

Pain assessment : infants 0-2 years

A
  • totally dependent
  • facial expression
  • pitch of cry
  • deviation from normal behaviours
  • older babies anticipate painful situation and cry
31
Q

Pain assessment : toddlers (1-2 years)

A
  • pain language 12-24 months
  • can describe pain and body part
  • fear of pain ful situations
  • anger, sadness, upset if painful situation
    *
32
Q

Pain assessment : Preschool (2-5 years)

A
  • think in concrete terms
  • cause and consequence of pain
  • magical thinking : may believe pain is punishment for unrelated behaviour or event
  • may be withdrawn if chronic pain
  • express themselves adn describe pain
33
Q

Pain assessment : School Aged children (6-12 years)

A
  • 7-10 years can explain why it hurts
  • cause and effect
  • can learn details about their pain
  • explanation of facts helpful
  • can have misperceptions that are allayed with knowledge
34
Q

Pain assessment : Adolescents > 12 years

A
  • can think in abstract way about pain
  • understand physical and psychological elements
  • Have insight
  • pain can be an injsutice and aggressor
  • receptive to coping strategies
  • Response to pain based on understanding of disease, emotional and cognitive factors
  • Worry is common
35
Q

Pain severity measures

A
  1. Self report
    1. FACES-R (FAces Pain Scale revised)
    2. Visual analogueu scale
  2. Observational / behavioural
    1. < 3 years and those with cog impairment
  3. Physiological
    1. heart rate, BP, RR etc. Poor correlation and not specific
36
Q

Behavioural / Observational responses to acute and chronic pain

A
  • ACUTE PAIN BEHAVIOURS
    • facial expression
    • positioning /body movement
    • Inability to be consoled
    • Crying
    • Moaning
  • CHRONIC PAIN BEHAVIOURS
    • abnormal posture
    • fear of being moved
    • lack of facial expression
    • lack of interest
    • withdrawn / quiet
    • irritable
    • low mood
    • poor sleep
    • anger
    • poor appetite
    • poor school performance
37
Q

2012 WHO Approach to Pain Management in Children with Medical Illness

A
  1. Detailed assessment
  2. By the clock
  3. Breakthrough analgesic
  4. By the most appropriate route (oral)
  5. By the child (tailor/titrate to child)
38
Q

WHO 2 step approach:

  1. Mild Pain
A
  • Acetaminophen (paracetamol)
    • safe under 3 months
    • syrup, tablets, cheweable, rectal, IV
    • 15mg/kg
    • hepatoxicity rare : malnutrition, interactions with carbamazepine, rifampicin, phenobarbitone
  • Ibuprofen
    • 10 mg/kg
    • care with dehydration
    • Cancer: risk of platelet dysfunction, bleeding
39
Q

WHO Step 2 : moderate to severe pain

A
  • Morphine first line
  • Half life of opioids is reduce in children
  • q4h IR formulation
  • q8h for CR formulation in some kids
    *
40
Q

Differences in opioids in children vs adults

A
  • dosage interval may need ot be shorter; half life is reduced in children > 12 months for morphine
    • q8h CR dosing
  • NEONATES / INFANTS < 12 months:
    • half life if INCREASED
    • reduced renal clearance
    • increased surface area
    • fat to muscle ratio
    • decreased glycoproteins
    • lower starting dose at q6-8h
    • 1/3 normal mg/kg dose if non ventilated
  • Oral route preferred
    • palatability important
    • open capsules, crush tablets, dissolve into solution and mix with food/drink
41
Q

Parenteral route if:

A
  • poor absorption
  • disordered Gi motility
  • inability to comply
  • unconscious
  • nausea
  • risk of aspiration
  • medication refusal
  • pain crisis needing rapid titration
42
Q

Other routes of medication adminstration

A
  • sc, IV, transdermal
  • No IM - painful
  • PICC or central line (port) used frequently
  • PCAs can be used by children > 7-8 years
  • Rectal route for infants/young children (opioids, anticonvulsants)
  • Transmucosal route
    • avoid first pass metabolism of GI tract, rapidly absorbed.
    • midazolam / fentanyl
    • Fentanyl 1-2 ug/kg intranasally
    • Midazolam 0.3mg/kg intranasally
43
Q

By the Child

A
  • Initiation :
    • < 50kg per KG
    • > 50 kg adult dosing
  • Titration:
    • by 50% previous opioid dose (if not opioid naive)
    • lowest effective dose with fewest side effects
  • Maintenance
    • long acting if possible
    • Long acting morphine granules
    • Fentanyl patch 12 ug = MEDD 30-40 mg
44
Q

Opioid switching / rotation

A
  • dose limiting side effects
  • dose reduction 25-30% for incomplete cross tolerance
  • used more liberally in children
45
Q

Opioid Side effects in children

A
  • Sedation - subsides
    • morphine 6 glucaronide
    • Psychostimulants not good evidence
  • Respiratory depression - rare with careful titration
    • naloxone 1 ug/kg q 3 minutes
  • Toxicity : same risk factors as adults
    • renal failure
    • removal of painful stimuli (intrathecal, radiation etc)
    • accidentally ingestions
  • rare paradoxical agitation
  • nausea - rare in peds
  • Constipation
  • Pruritis : more common in peds
  • Myoclonus
  • Urinary retention : more frequent
46
Q

Adjuvants in peds

A
  • Adjuvant = medication that has a primary indication for something other than pain, but has analgesic properties.
  • Steroids : not commonly used
  • Bisphosphonates : not commonly used, poor evidence
  • TCA, SSRI, SNRI : no good evidence
  • Ketamine
  • benzos, baclofen no good evidence
  • Many of these medications are trialled in palliative patients.
47
Q

Pain syndromes: Muscle Spasm

A
  • neuromusclar syndromes
  • Triggers: constipation, seizures, GERD, orthotic supports
    • Dantrolene
    • Baclfoen
    • Opioids
    • Botox
    • Intratehcal
    • Surgical interventions
48
Q

Peds Pain syndromes: Bone Pain

A
  • neuromuscular conditions, cerebral palsy, cancer (ALL)
  • inheited metabolic disorders, mucopolysaccarhidosis
  • osteogenesis imperfecta
  • HIV/AIDS: infection, osteopenia, cancer
  • distortion of normal skeleton
  • low bone density
  • increased fracture risk
  • Immobility, feeding difficulties, anticonvulsants, low Vit D

Treatment:

  • ortho surgery
  • 2 step WHO strategy
  • Bisphosphonate for osteopenia
  • radiation therapy
  • chemotherapy
  • radiopharmaceuticals
49
Q

Peds Pain syndromes: Neuropathic pain

A
  • numbness, itching, tingling, burning
  • shivering, tickling, fizzing, pricking
  • peripheral neuropathy : HIV AIDS
50
Q

Peds Pain Syndromes: Cerebral irritability

A
  • persistent unremitting agitation and distress
  • high pitched scream and pain behaviours:
    • spasticity, seizures, autonomic dysfunction, vx, sleep wake disturbance
    • chronic pattern
  • can be confused with agitated delirium at EOL
  • non verbal child with severe neuro impairment
  • infants with acute illness
  • kids with neurodegnerative disorders
  • EOL malignancy
  • pathophysiology unknown : central neuropathic and visceral hypersensitivity
  • abnormal brain and processing
  • Difficult to know if pain : morally treat as pain
  • Exclude other causes of pain
51
Q

Peds Pain Syndromes: Central Pain

A
  • damage to central somatosensory system
  • Neurodegenerative conditions, hypoxic or traumatic brain injury
  • Persistent screaming and distress
52
Q

Peds Pain Syndromes: Visceral Hyperalgesia

A
  • Altered response to visceral stimulation
  • Usually GI, bowels/digestion sx
  • Motor abnormality, high gut luminal pressures, high pain sensation
  • Feeding intolerance
  • ? result of painful repeated GI experiences in infancy
  • TCAs, anticonvulsants, gabapentin, NMDA antagonists
  • Benzos : midazolam or LA clonazepam up to 4 weeks
  • Opioids not first line, but are often used.
53
Q

Peds Pain Syndromes: Cancer Pain

A
  • WHO strategy
  • epidural/intrathecal blocks
  • RT
  • chemotherapy
  • Polypharmacy should be avoided
  • Similar strategy to adults
54
Q

Peds Pain Syndromes: Intractable Pain

A
  • palliative sedation acceptable
  • indications same as for adults
  • typical use in end stage cancer pain or HIV/AIDS
  • opioids, benzos, neuroleptics, anesthetic agents
55
Q

Team in peds palliative care:

A
  • nurses
  • mds
  • social workers
  • chaplain
  • allied health
  • therapists
56
Q

Role of nursing in peds palliative care

A
  • generalist nursing : core set of knowledge and skills
  • specialist palliative care nurse : support, consults
  • specialist interventions outside of palliative care: wound care, etc
57
Q

Volunteers

A
  • flexible
  • cost efficient
  • alleviates family distress
  • fill support gap
  • prevent family from feeling guilty or indebted to family/friends
58
Q

Symptom measurement tools in peds

A
  • Memorial Symptom Assessment Scale (MSAS)
    • ages 7-12
    • agres 10-18 versions
59
Q

Palliative Emergencies: Seizure control in peds

A
  • cerebral mets, metabolic derangement, infection, hypoxia
  • treat cause
  • Buccal midazolam 0.3 mg/kg, max 15 mg
  • status epilepticus : barbituate, propofol
60
Q

Spinal Cord Compression

A
  • unusual in children, late in cancer
  • back pain presenting sign
  • MRI, steroids, radiotherapy
61
Q

Emergencies: Bleeding in Peds

A
  • uncommon massive hemorrhage
  • use of blood products controversial if dependent on them
  • fear of bleeding can impact care and location of care
62
Q

Emergencies : terminal dyspnea

A
  • causes: pulm mets, intrinsice lung disease, infection, cardiac failure
  • acidosis, muscle weakness
  • NIV for neuromuscular disorders
  • bronchospasm : bronchodilators
  • 02, opioids, cbt, non pharm measures
  • careful use of benzos if + anxiety
63
Q

Emergencies : secretions

A
  • explanation to parents
  • positioning
  • gentle suctioning
  • anticholingerics
64
Q

Emergencies: terminal delirium

A
  • hypoxia, metabolic, CNS disease, infection, fever
  • reverse simple causes depending on prognosis, goals
  • haldol, benzo if terminal delirium
65
Q

Constipation in peds

A
  • reduced activity, metabolic derangement, obstruction, poor diet, poor fluid intake
  • opioids, meds
  • r/o obstruction
  • treatment:
    • diet
    • hydration
    • mobility
    • laxatives
    • senna, lactulose, peg
    • methylnaltrexone
66
Q

Fatigue in peds palliative

A
  • etiology: anemia, nutrition, metabolic, meds, dypsnea, psychological factors
  • stimulants limited data
  • opioid rotation for somnolence
67
Q

Insomnia in peds palliative

A
  • physical, mental, environmental factors
  • depression
  • lifestyle, behavioural changes, exercise
  • Low dose amitryptiline
  • melatonin
68
Q

Nausea and vomiting in peds palliative

A
  • vomiting centre in brain activated by:
    • cerebral cortex
    • vestibular apparatus
    • CRTZ
    • vagus nerve
    • direct action on vomiting centre
69
Q

Psychosocial issues in peds palliative

A
  • death of a child challenges beliefs and assumptions about world
  • parents will die before children
  • parents can protect their children
  • sense of confidence, safety and security as a parent
70
Q

QI Program in Peds Palliative

A
  • Identify quality lead to create and implement plan
  • Identify standards and measure clinical service against standards
  • DEvelop measures of quality for palliative care
  • Collate and evaluate data from QI programme, look for opportunities for improvement
  • Implement quality review ongoing basis as part of clinical care.
71
Q

Visiting an ill or dying parent

A
  • Explore and alleviate worries ahead of time
  • Prepare children for what they will see:
    • hospital, hospice
    • medical equipment
    • patients
    • physical condition
    • functional status of parent
  • Bring extra supportive adult who can leave when child is ready
  • Provide structure or activity for younger children
  • avoid agitated or delirious patient
  • Debrief after visit
  • Provides alternatives for personal visit
  • Many opportunities to say goodbye
72
Q

Codeine and children

A
  • Codeine is pro-drug metabolized to morphine by CYP 2D6
  • Polymorphic phenotypes
    • normal metabolizers
    • poor metabolizers
    • ultrarapid metabolizers
  • Unpredictable metabolism, can lead to rapid accumulation of morphine
  • Respiratory depression
  • Death
  • Do NOT use kids