Peds Drugs Flashcards

(74 cards)

1
Q

total body water preterm, full term and 5 months

A

85% preterm

75% full term

60% at 5 months

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2
Q

ECF preterm/full term, 1 year and adults

A

preterm/full term: 45-50%

1 year: 26%

adults: 18%

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3
Q

body fat premature, full term, 1 year and adults

A

preterm 3%

full term 12%

1 year 30%

adult 18%

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4
Q

methohexital rectal dose

A

25-35mg/kg

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5
Q

versed premed intranasal

A

0.2-0.3 mg/kg

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6
Q

versed sedation PR

A

1mg/kg

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7
Q

versed premed IV

A

0.05mg/kg

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8
Q

flumazenil

A

0.01 mg/kg

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9
Q

etomidate induction

A

0.2-0.6 mg/kg

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10
Q

etomidate sedation

A

0.1-0.3mg/kg

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11
Q

propofol >3yrs

A

2.5-3 mg/kg

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12
Q

propfol obese 3-7 yr

A

2mg/kg

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13
Q

propofol sedation infusion

A

125-150 mcg/kg/min

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14
Q

propofol emergence delirium dose

A

1-3mg/kg at end of anesthesia

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15
Q

what is ketofol

A

ratio of ketamine to prop 1:5 for 30 min of anesthesia and 1: 6.7 for 90 min

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16
Q

what do you coadmin with ketamine

A

versed 0.5mg/kg
atropine .02mg/kg

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17
Q

ketamine premed PO

A

6-10 mg/kg

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18
Q

ketamine premed IM

A

3-7mg/kg

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19
Q

ketamine sedation IV

A

0.5-2mg/kg

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20
Q

ketamine induction IV

A

1-2mg/kg

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21
Q

ketamine analgesic IV

A

0.1mg/kg

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22
Q

what does ketamine preserve

A

gag reflex
laryngeal irritability
continued muscle tension

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23
Q

effects of ketamine

A

increases HR, SBP
no resp depression

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24
Q

contraindications of ketamine

A

increased ICP
full stomach

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25
ketamine MOA
racemic, nonbarbiturate cyclohexamine derivative that produces dissociation of the cerebral cortex from the limbic system Antagonizes NMDA
26
precedex premed IM
1-2 mcg/kg
27
precedex premed intranasal
2mcg/kg (max 100mcg/dose) repeat prn 5-15 min
28
precedex premed IV
0.5mcg/kg
29
precedex sedation infusion
1-2mcg/kg over 10 min 0.5-1mcg/kg/hr children <1year up to 1.5mcg/kg/hr
30
precedex shivering dose
0.5mcg/kg
31
precedex emergence delirium dose IV
0.3mcg/kg
32
precedex MOA
selective α2-agonist with sedative and analgesic properties 1600 : 1 α2 to α1 (7x higher than clonidine) hyperpolarization of noradrenergic neurons in the locus coeruleus Mimics normal sleep, no resp depression, CV stable (biphasic response)
33
sevo neonate mac
3.3%
34
sevo yr old mac
2.6%
35
N2O dec mac
20%
36
des 2yr old mac
8.73%
37
morphine IV dose
0.1mg/kg
38
morphine caudal
30-50 mcg/kg
39
morphine intrathecal
5-7.5 mg/kg
40
meperidine IV
1-2mg/kg
41
meperidine info
Agonist at µ-opioid receptor & local anesthetic activity Active metabolite: Normeperidine Can accumulate with renal disease ->seizures Tx: shivering
42
fentanyl IV bolus analgesis
1-2mcg/kg
43
fentanyl IV bolus loading dose
5-10 mcg/kg
44
fentanyl IV cont infusion
1-3mcg/kg/hr
45
fentanyl intranasal dose
1-2 mcg/kg
46
oral transmucosal fentanyl
5-15mcg/kg
47
naloxone dose
0.01 mg/kg repeat every 2-3 min
48
naloxone info
competitive opioid antagonists at the µ-, κ-, and Δ-receptors high affinity but total lack of efficacy
49
ketorolac
0.5-1 mg/kg IM or IV until 16 yrs old MAX 30mg <2yr old 3 days >2 yrs 5 days
50
ketorolac info
Potent analgesia postoperative analgesia comparable to opioids, but without the side effects of respiratory depression, sedation, nausea, and pruritus Inhibits COX1 & COX2
51
tylenol (APAP) PO
10-15mg/kg
52
tylenol (APAP) rectal
40mg/kg
53
tylenol (APAP) IV
7.5-15mg/kg
54
tylenol MAX
< 2yo = 60mg/kg/day > 50 kg 4gm per day & 1gm per dose
55
atropine
0.02mg/kg
56
scopolamine
0.01mg/kg most effective antisialogues
57
robinul
0.01mg/kg
58
ondansetron
0.05 to 0.1 mg/kg up to 4 mg
59
dexamethasone info
significant glucocorticoid and minimal mineralocorticoid effects inhibits multiple inflammatory cytokines
60
succinylcholine info
-depolarizing muscle relaxant -Butyrylcholinesterase -Neonates and infants require about twice as much succinylcholine -Faster clearance, larger volume of distribution, and shorter onset time than children older than 2 years of age -marked variability in block produced by small doses of succinylcholine ---recommended to select doses at the upper end of the range for children undergoing rapid-sequence induction.
61
succinylcholine infant
Infants: 3 to 4 mg/kg is necessary
62
succinylcholine children
2 mg/kg is required to achieve the same duration
63
succs laryngospasm dose
0.1 to 0.2 mg/kg
64
succs side effects
dysrhythmias, increased intraocular pressure, prolonged apnea, injured muscle membranes with associated hyperkalemia, association with masseter spasm malignant hyperthermia, death Arrythmias – profound sustained sinus brady Intragastric pressure – increased w/ fasciculations -> aspiration Increased ICP – attenuated with NDMB, propofol, hyperventilation
65
succs with Duchenne muscular dystrophy
Intractable, unexpected cardiac arrest with 50& mortality BLACK BOX WARNING IN PEDIATRICS
66
Rocuronium
1.2 mg/kg (four times ED95 ) is alternative
67
non NMB RSI
Remifentanil 3 mcg/kg and propofol 3 mg/kg produce RSI conditions
68
Nimbex
0.4mg/kg
69
vecuronium <12 months
0.1mg/kg
70
vecuronium metabolite
3-OH metabolite accumulates in renal failure (80% active) Liver metabolism Kidney/Liver elimination
71
rocuronium
0.6mg/kg 1.2mg/kg RSI longer DOA in infants
72
neostigmine
50 mcg/kg
73
atropine reversal
7-10mcg/kg
74
robinul reversal
5mcg/kg