Peds Heme/Onc

Question 1

Neutrophilia with lots of bands (>700)

Answer 1

neonatal sepsis

Question 2

kidney disease associated with HIV

Answer 2

FSGS - most common nephrotic syndrome in adults

Question 3

Hep B kidney disease

Answer 3

Membranous nephropathy (nephrotic)

Question 4

pre-adolescent kidney disease

Answer 4

minimal change disease

Question 5

PSGN

Answer 5

nephritic

Question 6

Blood transufsions what electrolyte abnormality

Answer 6

Fe overload

Question 7

Reticulocyclopenia

from what infx

Answer 7

sudden arrest of erythropoesis

parvo B19

Question 8

Hemophilia A &B inheritance patten

Answer 8

X-linked recessive

usually males

Question 9

Parvo risk in sickle cell

Answer 9

aplastic anemia

Question 10

Shield Chest

Answer 10

Diamond Blackfan,
Noonan
Turner Syndrome

Question 11

ITP tx

Answer 11

glucocorticoids or IVIG

Question 12

Wiskott Aldrich triad

Answer 12

X-linked disorder with

1. thrombocytopenia
2. eczema
3. recurrent bacterial infx

Question 13

ALL

Answer 13

Hepatospleenomegally
lymphadenopathy
petichiae

Question 14

nasal obstruction with visible mass
bony errosion
epistaxis

Answer 14

Juvenile angiofibroma

Question 15

Juvenile angiofibroma

Answer 15

nasal obstruction with visible mass
bony errosion
epistaxis

Question 16

renal failure
hemolytic anemia
thrombocytopenia

s/p diarrhea

Answer 16

Hemolytic Anemia

Question 17

Diamond Blackfan anemia vs. Megaloblastic

Answer 17

Both are Macrocytic

Diamond Blackfan results in no hypersegmentation of nucleus in neutrophils

Question 18

Macrocytic Anemia with Congenital anomalies and low retic count

Answer 18

Diamond Blackfan anemia

Question 19

Diamond Blackfan anemia tx

Answer 19

corticosteroids/ transfusions

Question 20

Wiskott-Aldrich inheritence

Answer 20

X-linked

Question 21

Eczema
Low Platelets
Hypgammaglobulinemia

Answer 21

Wiskott-Aldrich

Question 22

Red Cell Aplasia

Answer 22

Transient Erythroblastopenia

Question 23

Pancytopenia and Macrocytosis and

Cafe Au Lait spots, microcephaly, horshoe kidneys, no thumbs (not triphalangeal thumbs)

Answer 23

Fanconis

Question 24

Fanconis

Answer 24

Pancytopenia and Macrocytosis and

Cafe Au Lait spots, microcephaly, horshoe kidneys, no thumbs (not triphalangeal thumbs)

Question 25

Fanconi's age

Answer 25

8 years

Question 26

Diamond Blackfan anomalies

Answer 26

Sheild Chest, Triphalangeal thumbs, short with webbed neck and cleft lip

Question 27

Heinz bodies

Answer 27

hemoglobin precipitates... found in G6PD deficiency

Question 28

low Retic

Answer 28

Fe def, B12 def, chemo, infx, aplastic anemia

Question 29

neonatal polycythemia

Answer 29

delayed clamping of umbilical cord May cause respiratory distress, hypoglycemia Hct>65%

Question 30

Leukocytosis Anemia Thrombocytopenia

Answer 30

ALL Pain insidious and worse at night

Question 31

Pancytopenia after drugs or toxin exposure or viral infections

Answer 31

Aplastic Anemia

Question 32

``` anemia hyperpigmentation on trunk and intertrigenous areas cafe au lait short stature hypogonads renal changes eyelid changes ```

Answer 32

Fanconis Thrombocytopenia is first then neutropenia then anemia

Question 33

Diamond Blackfan age

Answer 33

first 3 months of life

Question 34

Transient Erythroblastopenia of Childhood (TEC)

Answer 34

acquired aplastic anemia gradual pallor and tachycardia normocytic normochromic anemia

Question 35

prolonged aPTT but not PT in newborn

Answer 35

Factor 8 def (similar to vWD)

Question 36

mucocutaneous bleeding petechiae normal PT, normal aPTT

Answer 36

uremia aspirin/clopidogrel Glanzmann throbasthenia congenital disorder

Question 37

MCC inherited bleeding d/o

Answer 37

von Willebrand dz may present similar to Factor 8 def

Question 38

prolonged PT and aPTT in newborn

Answer 38

think Vitamin K def

Question 39

hypochromic microcytic anemia with family hx

Answer 39

Alpha Thal

Question 40

hypochromic microcytic anemia from 6-12 months

Answer 40

Beta Thal

Question 41

Hemophilia A

Answer 41

Factor 8

Question 42

Hemophilia B

Answer 42

Factor 9

Question 43

Fe deficiency vs. spherocytosis

Answer 43

Fe deficiency has increased RDW

Question 44

vitamin K clotting factors

Answer 44

2, 7, 9, 10, Protein C, Protein S

Question 45

how to diagnose ALL

Answer 45

bone marrow biopsy

Question 46

Anisocytosis

Answer 46

red blood cells of different size common in Fe def. anemia

Question 47

what is normal level of reticulocytes

Answer 47

0.5% - 1.5%

Question 48

low retic vs. high retic

Answer 48

low retic = leukemia or infection or aplastic anemia high retic = hemolysis or maybe hemorrhage