Penicillin

Question 1

Penicillin act by
A. Inhibition of protein synthesis
b. intefering cell wall synthesis
c. phagocytosis of bacteria

Answer 1

b. intefering cell wall synthesis

penicillin are bactericidal

Question 2

Natural penicillin which is administered only oral route

Answer 2

pen v

Question 3

Penicillinase-resistant penicillin include

a. pen v
b. methicillin
c. ampicillin

Answer 3

b. methicillin

including nafcillin, dicloxacillin, oxacillin

Question 4

Flucloxacillin is effective in skin infx treatment. T/F?

Answer 4

T

Question 5

Which of the following statement abt penicillin is false?

a. ticarcillin is resistant to beta-lactamase
b. penicillin are bacteriostatic
c. pen v via oral,IV,IM
d. all

Answer 5

d. all

Question 6

Which of the following abt clavulanic acid is false?

a. it is beta lactamase inhibitor
b. has no antibacterial activity
c. bears a beta lactam ring
d. none

Answer 6

d. none

• clavulanic acid is a potent inhibitor of beta lactamase
• no intrinsic antibacterial activity by itself but prevents antibacterial drug being broken down by betalactamase

Question 7

Most common side effect of ampicillin

a. diarrhea
b. renal failure
c. head ache
d. jaundice

Answer 7

a. diarrhea

Question 8

Example of antistaphylococcal penicillin

a. pen g
b. nafcillin
c. procaine penicilline
d. none

Answer 8

b. nafcillin

penicillinase-resistant penicillin is not hydrolysed by staph penicillinase (betalactamase)

Question 9

Which penicillin dont required dosage adjustment in renal failure?

a. piperacillin
b. nafcillin
c. ampicillin
d. none

Answer 9

b. naficillin

nafcillin and oxacillin are primarily metabolised by liver

Question 10

Which dont hv antibacterial activity?

a. pen g
b. penicilloic acid
c. nafcillin

Answer 10

b. penicilloic acid

Question 11

Which hv potential to cause interstitial nephritis?

a. methicillin
b. piperacillin
c. oxacillin
d. ampicillin

Answer 11

a. methicillin

Question 12

Which is active against pseudomonas?

a. ticarcillin
b. dicloxacillin
c. pen g
d. ampicillin

Answer 12

a. ticarcillin

piperacillin and ticarcillin are antipseudomonal

Question 13

bacterial resistance to penicillin occur due to

a. beta lactamase activity
b. decrease permeability to drug
c. altered PBP
d. all

Answer 13

d. all

Question 14

What structural feature of penicillin is involved in its MOA?

a. disulfide bond
b. COOH
c. acyl side chain
d. beta lactam ring

Answer 14

d. beta lactam ring

Question 15

Which is beta lactamase inhibitor?

a. clavulanic acid
b. nafcillin
c. meropenem

Answer 15

a. clavulanic acid

Question 16

A penicillin preparation which is suitable for oral administration is

A. Benzathine Penicillin

B. Benzylpenicillin

C. Procaine benzylpenicillin

D. Phenoxymethylpenicillin

Answer 16

D. Phenoxymethylpenicillin

Question 17

Penicillinase-resistant penicillins include

A. benzylpenicillin

B. phenoxymethylpenicillin

C. cloxacillin

D. ampicillin

Answer 17

C. cloxacillin

Question 18

Co-amoxiclav is a:

A. penicillin-beta-lactamase inhibitor combinations

B. penicillin active against gram negative bacteria.

C. carbapenem group of antibiotic.

D. narrow spectrum penicillin.

Answer 18

A. penicillin-beta-lactamase inhibitor combinations

Question 19

Which statement about penicillins is FALSE

A. Penicillins cross CSF if the meninges are inflamed.

B. Benzylpenicillin is highly active against Streptococcus pneumoniae .

C. Procaine penicillin, given i.m. only.

D. penicillins do not cause neutropenia in high does given for longer than 10 days.

Answer 19

D. penicillins do not cause neutropenia in high does given for longer than 10 days.

Question 20

Which statement about penicillins is TRUE

A. Penicillins on high doses cause convulsions.

B. Benzylpenicillin is not effective for infections due to normal strains of Neisseria meningitidis

C. Phenoxymethylpenicillin is not resistant to gastric acid.

D. Penicillins are not effective against normal strains of gram positive bacteria.

Answer 20

A. Penicillins on high doses cause convulsions.

Question 21

Identification of methicillin-resistant Staphylococcus aureus (MRSA) in patients indicates:

A. the organisms are sensitive to flucloxacillin and cloxacillin

B. the organisms are sensitive to beta-lactam antibiotics

C. the organisns are resistant to flucloxacillin, cloxacillin, and other beta-lactam antibiotics

D. usual infection-control measures are satisfactory to manage the infections.

Answer 21

C. the organisns are resistant to flucloxacillin, cloxacillin, and other beta-lactam antibiotics

Question 22

Which statement about ampicillin is FALSE:

A. Ampicillin cause diarrhoea on oral administration.

B. Ampicillin may cause maculopapular rashes

C. Amoxycillin is better absorbed from gut than ampicillin.

D. Ampicillin is a cephalosporin group of antibiotic.

Answer 22

D. Ampicillin is a cephalosporin group of antibiotic.

Question 23

Ureidopenicillins are:

A. adapted from the ampicillin molecule, and effective against Pseudomonas aeruginosa

B. carboxypenicillins .

C. monobactam antibiotics.

D. beta-lactamase resistant penicillins.

Answer 23

A. adapted from the ampicillin molecule, and effective against Pseudomonas aeruginosa

Question 24

Which one ofthe following drugs is an antipseudomonal penicillin?
A. Cephalexin
B. Cloxacillin
C. Piperacillin
D. Dicloxacillin

Answer 24

C. Piperacillin

Antipseudomonal penicillins

Carboxypenicillins
Carbenicillin
Ticracillin
Ureidopenicillins
Piperacillin
Mezlocillin

Question 25

Most common s/e of oral administration of ampicillin is

Answer 25

diarrhea

Question 26

Penicillin is effective against a. neisseria meningitidis b. neiserria gonorrhea c. treponema pallidum d. all

Answer 26

d. all

Question 27

Which is penicillinase-resistant penicillin? a. amoxicillin b. cloxacillin c. ampicillin d. pen g

Answer 27

b. cloxacillin

Question 28

Clavulanic acid added to ampicillin cause a. increase effectiveness against g-ve b.inhibit b lactamase increase effectiveness against g+ve

Answer 28

b.inhibit b lactamase

Question 29

Which antibiotic is effective against pseudomonas? a. methicillin b. carbenicillin c. oxacillin

Answer 29

b. carbenicillin piperacillin,ticarcillin and carbenicillin is antipseudomonal

Question 30

Which has best g-ve spectrum? a. methicillin b. ampicillin c. pen v

Answer 30

b. ampicillin

Question 31

B lactam antibiotics are a. penicillin b. imipenem c. cephalo d. all

Answer 31

d. all

Question 32

pen g combine with probenecid result in a. increase excretion of probenecid in feces and perspiration b. increase excretion of probenecid in urine c. increase metabolism of pen g d. decrease renal excretion of pen g

Answer 32

d. decrease renal excretion of pen g Probenecid is sometimes used along with penicillin antibiotics (e.g., penicillin, ampicillin, nafcillin) to increase antibiotic blood levels. This increase makes the antibiotic work better at treating certain infections. Probenecid works by decreasing the kidneys' ability to remove the antibiotic from the body.

Question 33

Clavulanic acid is combined with amoxicillin to a. reduce risk of allergy b. prolong amoxicillin half life c. reduce severity of darrhea d. extend amoxicillin antibacterial spectrum

Answer 33

d. extend amoxicillin antibacterial spectrum Clavulanic acid is a beta-lactamase inhibitor that is frequently combined with Amoxicillin or Ticarcillin to fight antibiotic resistance by preventing their degradation by beta-lactamase enzymes, broadening their spectrum of susceptible bacterial infections