Penicillin

Question 1

Penicillin is from what fungi?

Answer 1

Penicillium notatum

Question 2

Classifications of Penicillin

Answer 2

• narrow-spectrum penicillins
  -broad-spectrum penicillins

Question 3

Narrow spectrum penicillin classifications

Answer 3

-natural penicillin
- very-narrow spectrum penicillins

Question 4

NP:
used primarily on gram-positive bacterias

Answer 4

Penicillin G

Question 5

NP:
treatmenr of all stages of syphilis, mild to moderate pneumococcal pneumonia, and adjunctive in the treatment of diptheria

Answer 5

Penicillin G Procaine

Question 6

NP:
treatment for miked to moderate infections of the upper respiratory tract, syphilis, yaws, bejel, pinta

Answer 6

Penicillin G Benzathine

Question 7

NP:
treatment for respiratory tract infection, scarlet fever

Answer 7

Penicillin V Phenoxymethylpenicillin

Question 8

VNS:
treat infections caused by susceptible gram-positive bacteria, those produce B-lactamases

Answer 8

Methicillin

Question 9

VNS:
treat Methicillin-susceptible S. aureus infections

Answer 9

Oxacillin

Question 10

VNS:
treat beta-hemolytic streptococcal, pneumococcal, and staphylococcal infections, including those produced beta-lactamase

Answer 10

• Cloxacillin
• Dicloxacillin

Question 11

VNS: treat infections caused by penicillinase-producing staphylococci which have shown susceptibility to the drug

Answer 11

Naficillin

Question 12

Classifications of Broad-spectrum penicillins

Answer 12

-broad spectrum
- extended spectrum

Question 13

BS:
- treat Gram-negative bacilli
- treat acute urinary tract infection
- for gonorrhea

Answer 13

Ampicillin

Question 14

BS:
- systemic urinary tract infection
- bacillary dysentery

Answer 14

Amoxicillin

Question 15

ES:
- systemic urinary tract infection caused by Paeruginosa, indole producing Proteus spp and Providencia spp

Answer 15

Carbenicillin disodium, disodiumcarboxybenzylpenicillin

Question 16

ES:
- serious infections requiring high dose therapy

Answer 16

Ticarcillin

Question 17

ES:
- serious infections caused by Klebsiella spp, P. Aureginosa, anaerobic, streptococcus faecalis, H. Influenzae

Answer 17

Mezlocillin

Question 18

ES:
- used to treat pneumonia,, and skin skin, gynecological and abdominal stomach area infections caused by bacteria

Answer 18

Piperacillin

Question 19

MOA: B-lactamase Inhibitors
- mold product that has only weak intrinsic antibacterial activity but an irreversible b-lactamase inhibitor

Answer 19

Clavulanic acid

Question 20

MOA: B-lactamase inhibitor
- prepared by: partial chemical synthesis from penicillins
- enhanced potency if e oxidize ang sulfur to sulfone
- toxicity: yellowing of the skin or eyes and hoarsenes

Answer 20

Sulbactam

Question 21

MOA: B-lactamase inhibitors
- co-administered w/ piperacillin
- little to no antibacterial activity

Answer 21

Tazobactam