Perio Flashcards Preview

DAOB321 > Perio > Flashcards

Flashcards in Perio Deck (31):
1

These bacteria are gram positive cocci associated with periodontal health

Streptococcus Sanguinis
Streptococcus Gordonii

2

These are gram positive rods associated with gingivitis

Actinomyces isrealii
Actinomycels naeslundii

3

These are gram negative bacteria associated with tissue destruction in periodontitis

Porphyromonas Gingivalis
Tannerella Forsythia
Treponema Denticola

4

This is a spirochete associated with periodontal tissue destruction

It is a strict anaerobe, found in large numbers where?

Treponema Denticola

At the base of pockets (attachment loss)

5

This is a gram negative, anaerobic rod associated with tissue destruction in periodontitis

Healthy children and adolescents harbor none of it

Most patients have a single clone

Stronly correlated with periodontits, multiple virulence factors

Porphyromonas Gingivalis

6

This is a gram negative anaerobic rod strongly associated with periodontitis and possibly involved in its initiation

Tanerella Forsythia

7

This bacteria is a gram negative coccobacillus

What is it strongly associated with some cases of?

Some strains produce a toxin that kills neutrophils and macrophages

Aggregatibacter actinomycetemcomitans

Localized Aggressive Periodontitis

8

This cytokine stimulates osteclast activity, resulting in bone resorption.

Also induces breakdown of collagen in gingiva, periodontal ligament and alveolar bone

Cytokine IL-1

9

This cytokine stimulates bone resorption and inhibits bone formation

IL-6

10

This cytokine stimulates connective tissue destruction and bone resportion

IL-8

11

So IL-1, IL-6, and IL-8 stimulate bone resoprtion, among other things

!

12

This cytokine stimulates bone resorption and induces the breakdown of collagen matrix in the gingiva periodontal ligament, and alveolar bone

Cytokine TNF-alpha

13

The molecule stimulates MMP secretion and stimulates bone resorption

Prostglanding E2 (PGE2)

14

These molecules induce breakdown of collagen matrix in the gingiva, periodontal ligament, and alveolar bone

Matrix Metalloproteinases (MMPs)

15

This system provides a second line of defense when bacterial pathogens invade immune cells

When activated, they stimulate direct killing (lysis) of bacteria via MACs, opsonization of pathogens, and recruitment of additional cellular defenders

The complement system

16

Phagocytes like PMNs and later Macrophages are recruited to the periodontal lesion and part of the innate immune response

They are recruited by several means, including:

The alternate pathway of this system, molecules like C3a, C5a, vasodilation, expression of ICAM-1

These molecules on phagocytes that recognize macromolecules unique to bacteria, like LPS for gram positive and lipotechoic acid for gram positive bacteria, allowing for activation and proliferation

This molecule that is chemotactic for PMNs and macrophages

This molecule that is chemotactic for the B cell

Complement Activation

Toll Like Receptors

fMet-Leu,Phe

C5a

17

LPS is a TLR found where?

Gram negative bacteria

18

Lipoteichoic acid is a TLR found where?

Gram positive bacteria

19

Acute inflammation is characterized by:

PMNs

20

Chronic inflammation is characterized by:

Macrophages, B cells, plasma cells

21

Healing is characterized by:

Fibroblasts, endothelial cells, epithelial cells

22

If chronic inflammation is allowed to persist, you have persistance of inflammatory cells and cytokines leading to tissue destruction, termed

Friendly Fire

23

This is an acute phase response protein that is part of the innate immune system

C-reactive Protein

24

These two molecules are part of the INNATE immune system and the alternate complement pathway

C3a, C5a

25

Acid hydrolases, elastase, proteases are part of innate immunity and are associated with these cells

PMNs

26

Cytokines IL-1, 6, 8, TNF-alpha, PGE 2, are associated with this cell of innate immunity

Macrophages

27

Toll like receptors are innate or adaptive?

Innate

28

B cells and T cells are innate or adaptive?

Adaptive

29

The classic complement pathway is innate or adaptive?

Adaptive

30

What molecules of adaptive immunity do T cells secrete?

Cytokines IFN-gamma, IL2, IL6

31

These helper T cells are pro-inflammatory, they secrete IFN gamma

Th1 cells