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Flashcards in periodontitis- risk for systemic disease Deck (32):
1

what were the problems with the focal infection concept

• Extracting teeth didn’t necessarily cure disease

• People with good oral health and no infection still developed systemic diseases

• People with no teeth still developed systemic diseases

2

list the steps of the acute-phase reaction cascade

Triggering factors

Local reaction

Mediators

Secondary systemic reaction

3

what are the "triggering factors" of the acute-phase reaction cascade?

– Infection
– Necrosis
– Surgery
– Neoplasia
– Radiation

4

list the cell types involved in the "local responses" during the acute-phase reaction cascade

– Macrophages
– Fibroblasts
– Endothelial and other cells

5

_________ are responsible for the production and release of inflammatory cytokines

mediators

6

what inflammatory mediators are involved in the acute-phase reaction cascade?

– TNF-alpha
– IL-1
– IL-6
– IFN-gamma

7

what are the characteristics of a secondary systemic reaction?

– Fever and leukocytosis
– Complement activation
– Serum glucocorticoids increased
– Altered synthesis of acute phase proteins

8

opsonization, lysis, and chemotaxis (CTX) are all _______ components

compliment

9

what does alpha2-macroglobulin inhibit?

protease

(inhibits enzyme)

10

what are C-reactive proteins involved in?

opsonization

11

T/F: fibrinogen and plasminogen are important in the acute phase

true

12

_____% of Americans 30 yrs and older (64.7 million total) have periodontitis

47

13

Periodontal pockets provide a significant surface area exposed to ________ biofilm

gram-negative

14

during periodontitis, there is a systemic exposure to what?

– Bacteria and bacterial products
– Inflammatory cytokines

15

what systemic conditions can be caused by periodontitis?

- Atherosclerotic vascular disease
- Adverse pregnancy outcomes
- Diabetic complications
- Respiratory infections

16

Atherosclerosis leads to fibro-lipid lesions called ________

atheromas

17

what are the common complications of atherosclerosis?

Coronary thrombosis and acute myocardial infarction

18

what 2 things can cause an Acute phase reaction?

Systemic Inflammation & Bacterial Translocation

19

what are the major confounding factors associating periodontitis with AVD?

• Smoking
• Age
• Diabetes
• Educational and socioeconomic status

20

T/F: DeStafano found that periodontitis is associated with a small increase in risk for coronary heart disease in men

true

21

what did the matilla study find?

it showed a significant association between poor oral health and MI (myocardial infarction)

22

the ______ study revealed a small association between tooth loss and coronary heart disease.

Joshipura

23

the study by _______ found that periodontitis can influence atheroma formation

Beck

24

what study found no link between periodontal disease and CHD risk

Hujoel

25

Periodontal patients treated with Sc/RP experienced significant reductions in serum _____ and ____

CRP and IL-6

26

T/F: There is currently a lack of strong evidence that treatment of periodontitis reduces the risk of atherosclerotic vascular disease.

true

27

Periodontal pathogens have been isolated from human carotid _______

atheromas

28

the bacterial species _________ can induce platelet aggregation

P. gingivalis

29

T/F: According to the AHA, there is evidence to indicate that perio treatments can prevent AVD

FALSE

there is not enough evidence to indicate that it can prevent AVD or modify its outcomes

30

T/F: Poorly controlled diabetics of both types tend to have more periodontal attachment loss than non-diabetics

true

31

T/F: there is conclusive evidence for an association between periodontal disease and COPD, probably due to inhaled oral bacteria

false

we have yet to establish a link

32

It is likely that well-controlled ___________ studies will provide the strongest evidence of periodontitis as a risk factor for systemic health

intervention