Peripheral Nerves and the Autonomic Nervous System Flashcards
(39 cards)
Afferent
-Sensory neurons -to CNS -travel through spinal cord and cranial nerves to the medulla
Efferent
-Motor neurons -away from CNS
Somatic (Efferent)
-Innervates skeletal muscle
Autonomic (Efferent)
-involuntary -innervates smooth muscle, cardiac muscle, GI, etc.
Nociceptors
Respond to chemicals and can also be referred to as chemoreceptors
Mechanoreceptors (Stretch receptors)
-Pressure, stretch -Action postentials from pulmonary mechano-stretch receptor sensory neurons
Proprioceptors
Change in muscle or tendon length/tension, an example would be the patellar tendon reflex
Nociceptors/chemoreceptors
Example would be vagal afferent nerves responding to endogenous agents
What does tetrodotoxin (puffer fish) inhibit at the NM junction? What symptoms would that cause?
Blocks voltage gated Na+ channels. It would block sympathetic and parasympathetic pathways so paralysis, respiratory failure, blurred vision, vertigo, numbness, paresthesia, nausea and ataxia.
What does conotoxin (cone snails) inhibit?
Voltage gated Ca++ channel blocker that doesn’t allow the release of NT in the synaptic cleft. If no NT is released, the signal is terminated so you lose response of the postganglionic effect. Ex. muscle paralysis of the diaphragm that causes respiratory arrest.
What does dendotoxin (mamba snakes) inhibit?
They block voltage gated K+ channels therefore enhancing the release of Ach at NMJ. Initially results in muscle hyper excitability and convulsions,
What is the mechanism of action of botulinum toxin?
Block Ach release from the nerve terminal by inhibiting the SNARE complex, thus no Ach release and no effect.
How does nerve gas work, and what effects does it have?
They block the effects of acetylcholinesterase activity which increases the duration of Ach in the synaptic cleft. So symptoms would include salvation, excretions, constricted pupils
What is a motor unit?
Motor neuron and all the skeletal muscle fibers that it innervates
Can be one neuron to multiple muscle fibers (back muscles) or one neuron to only a few fibers (hands and face)
Where do efferent autonomic nerves typically originate?
Medulla
How is heart rate affected during inspiration?
- Decreases in parasympathetic output from ANS
- Increases cardiac pacemaker
- Increases HR
How is heart rate affected during expiration?
- Decreases HR
- Increase in parasympathetic (vagus nerve) output from ANS
- Slows cardiac pacemaker
How does the pathways differ from sympathetic and parasympathetic when talking about the length of preganglionic/postganglionic axons and origination of nerves?
Sympathetic -> Shorter preganglionic nerves and longer postganglionic nerves, nerves usually originate in the spinal cord at a location near to the effector organ.
Parasympathetic -> Very long preganglionic neuron and originates in the medulla of brainstem and some in the sacral region
How can the sympathetic pathway affect organs without innervation (such as a heart transplant)?
Sympathetic preganglionic neurons also stimulate the adrenal medulla to release epinephrine into the blood stream that can lead to sympathetic affects in the heart
Overview Neurotransmitters and Receptors used by the ANS:
What are the two Ach receptors used by the ANS? Agonists and antagonists of each?
What are the main adrenergic receptors used by the ANS?
alpha and beta
How to alpha 1,2 receptors respond to Epi and NE?
They both have variable affinities:
a1: NE > E (Ex. blood vessel constriction/BP)
a2: E => NE (Ex. presynaptic neuron)
Where are the locations of B1 and B2 receptors? How does Epi and NE differ in thier responses at each receptor?
B1: Epi > NE (ex. Inc. Heart Rate and cardiac contractility)
B2: Epi >> NE (ex. Bronchodilation, some vasodilation)
