Flashcards in Pestana Organ Transplantation Deck (10)
absolute contraindication to organ donation
3 ways transplant rejection can happen
When does hyperacute rejection occur?
within MINUTES of reestablishing blood supply to the transplanted organ - caused by preformed antibodies
How do you prevent hyperacute rejection?
ABO matching and lymphocytotoxic cross-matching
When does acute rejection occur?
>5 DAYS but within the first 3 MONTHS
What should you do if LFTs begin to rise in a patient with transplanted liver?
R/O biliary obstruction by US and vascular thrombosis with Doppler
Management of a patient with transplanted heart?
routine ventricular biopsies since signs of functional deterioration usually occur too late to allow effective therapy
Treatment of acute rejection?
Steroid boluses (1st line)
Lympocyte agents (OKT3)
When does chronic rejection occur?
YEARS, with insidious loss of organ function