Pharm Flashcards
1
Q
contraindications to heparin use?
A
- hemorhage
- hemophilia
- active gastroduodenal ulcer
- thrombocytopenia
- allergy
- recent major trauma
- hemorhagic CVA
2
Q
MOA of LMWH
A
inactives factor Xa
3
Q
LMWH will accumulate in ______
A
renal failure
4
Q
enoxaparin AKA
A
clexane
5
Q
prophylactic dose of enoxaparin?
A
40 mg SC OD
6
Q
Innohep =
A
tinzaparin
7
Q
unfractionated heparin MOA
A
binds antithrombin and inhibits thrombin, factor Xa and IXa
8
Q
uses of unfractionated heparin?
A
- anticoagulation for prosthetic heart valves
- acute limb ischemia
9
Q
dose and monitoring of heparin?
A
- stat 5000 IU bolus
- 1000 IU / hour
- check aptt 4- 6 hrs and aim for apt of 60-90
10
Q
warfarin MOA
A
inhibits vitamin K dependent clotting factors
11
Q
how to reverse warfarin?
A
- Vitamin K
- Prothrombin concentrate complex
- fresh frozen plasma
12
Q
advantages of NOACs
A
- no need for INR monitoring
- no bridging
- short half life - out of system in 24-75 hours
13
Q
aspirin MOA
A
- cyclooxegenase inhibitor
- inhibits platelet aggregatin
14
Q
whats is the dose for low dose aspirin?
A
75 mg
15
Q
what is the dose for high dose aspirin?
A
300 mg
