Flashcards in Pharm 14- Platelet Inhibitors, Thrombolytics, AT-III Deck (80)
When is Streptokinase (Streptase) given?
Within 4 hours of an MI via slow infusion
How is Streptokinase (Streptase) monitored?
Thrombin Time (TT)
What do Urokinase (Kinlytic) do?
Directly converts plasminogen into plasma to dissolve clots
What is the half-life of Urokinase (Kinlytic)?
What is Urokinase (Kinlytic) approved for?
Use in PE
What is Urokinase (Kinlytic) made from?
What do certain malignant tumors produce and how does it work?
Urokinase (kinlytic) to help "invade" tissues
Mesupron acts as a uPA inhibitor
non-cytotoxic chemotherapeutic effects
What is Alteplase/tPA (Activase) and how does it work?
Naturally occuring enzyme form human cancer cells, tPAs selectively and directly binds with plasminogen that is bound to fibrin (as in a clot)
In low doses, free plasminogen is hardly affected but bound fibrinogen is selectively targeted so you get more clot lysis and less diffuse hemorrhagic problems as compared to streptokinase
What is Alteplase/tPA (Activase) used for?
What is the half life of Alteplase/tPA (Activase)?
What is Reteplase (Retavase)?
A synthetic close relative of tPA
Cheaper than tPA
Less fibrin-specific than tPA
What is antithrombin?
Antithrombin (AT) is a small protein made in the liver
What is the half-life of antithrombin?
What is antithrombin referred to as?
Antithrombin III (ATIII)
What does ATIII work with to effect anticoagulation?
What does normal ATIII have an effect on?
Thrombin and Factors IXa and Xa; that effect is multipled by thousands to millions of times when combined with heparin
What are the two types of antithrombin available?
1. Thrombate (Made from pooled human plasma)
2. Atryn (Made form milk genetically modified goats)
Atryn vs Thrombate
Atryn is 40% cheaper to use than thrombate
Atryn's half life is 9 hours/ thrombates 3 days
Atryn must be refrigerated, thrombate room temp
Recent perfusion trend is toward using which antithrombin?
Away from thrombate and more toward atryn