Pharm 14- Platelet Inhibitors, Thrombolytics, AT-III Flashcards Preview

Pharmacology > Pharm 14- Platelet Inhibitors, Thrombolytics, AT-III > Flashcards

Flashcards in Pharm 14- Platelet Inhibitors, Thrombolytics, AT-III Deck (80)
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61

When is Streptokinase (Streptase) given?

Within 4 hours of an MI via slow infusion

62

How is Streptokinase (Streptase) monitored?

Thrombin Time (TT)

63

What do Urokinase (Kinlytic) do?

Directly converts plasminogen into plasma to dissolve clots

64

What is the half-life of Urokinase (Kinlytic)?

20 minutes

65

What is Urokinase (Kinlytic) approved for?

Use in PE

66

What is Urokinase (Kinlytic) made from?

Urine

67

What do certain malignant tumors produce and how does it work?

Urokinase (kinlytic) to help "invade" tissues
Mesupron acts as a uPA inhibitor
non-cytotoxic chemotherapeutic effects

68

What is Alteplase/tPA (Activase) and how does it work?

Naturally occuring enzyme form human cancer cells, tPAs selectively and directly binds with plasminogen that is bound to fibrin (as in a clot)

In low doses, free plasminogen is hardly affected but bound fibrinogen is selectively targeted so you get more clot lysis and less diffuse hemorrhagic problems as compared to streptokinase

69

What is Alteplase/tPA (Activase) used for?

aMIs
Thrombotic strokes
PE

70

What is the half life of Alteplase/tPA (Activase)?

5-30 minutes

71

What is Reteplase (Retavase)?

A synthetic close relative of tPA
Cheaper than tPA
Less fibrin-specific than tPA

72

What is antithrombin?

Antithrombin (AT) is a small protein made in the liver

73

What is the half-life of antithrombin?

0.5-3 days

74

What is antithrombin referred to as?

Antithrombin III (ATIII)

75

What does ATIII work with to effect anticoagulation?

Heparin

76

What does normal ATIII have an effect on?

Thrombin and Factors IXa and Xa; that effect is multipled by thousands to millions of times when combined with heparin

77

What are the two types of antithrombin available?

1. Thrombate (Made from pooled human plasma)
2. Atryn (Made form milk genetically modified goats)

78

Atryn vs Thrombate

Atryn is 40% cheaper to use than thrombate
Atryn's half life is 9 hours/ thrombates 3 days
Atryn must be refrigerated, thrombate room temp

79

Recent perfusion trend is toward using which antithrombin?

Away from thrombate and more toward atryn

80

What is ATIII used to treat?

Tx of acquired or congenital ATIII deficiency