Pharm Flashcards
(67 cards)
what’s Insomnia?
difficulty falling asleep
ADHD
M=F
F>M
M>F
M>F
CDC
Smooth muscle relaxation is caused by which of the following drugs?
- prazosin
- atropine
- theophylline
- amphetamine
prazosin
(alpha-1 blocker, on vascular smooth muscle)
wiki
what’s epinephrine reversal?
Phenoxybenzamine
Mosby
MOA of Neostigmine?
it’s Cholinergic Agonists
MOA of Glycopyrrolate
it’s anticholinergic
MOA of Atropine?
it’s anticholinergic
Miosis vs Mydriasis
Miosis: pupil constriction
Mydriasis: pupil dilation
MOA of pilocarpine
cholinergic agonist
increase salivation
MOA of Cimeviline
cholinergic agonist
increase salivation
MOA of Propantheline bromide
anticholinergic
theraputic index
LD/ED
Lethal dose/effective dose
(FA)
MOA of Succinylcholine
Adverse effect of Succinylcholine
MOA: Blocks ACh on skeletal m. => relaxes skeletal m.
(for intubation)
adverse effect: apnea (sessation of breathing)
patient who has Parkinson’s disease is being treated with levodopa. Which of the
following characterizes this drug’s central mechanism of action?
a. it replenishes a deficiency of dopamine
b. it increases concentrations of norepinephrine
c. it stimulates specific L-dopa receptors
d. it acts through a direct serotonergic action
a. it replenishes a deficiency of dopamine
asda
what’s the bioavailability of a drug?
A measure of how much drug is in the BLOOD
FA
There are two drugs that with the same dosages bind to the same receptor and have same
intrinsic affect however different affinities for the receptor: How are these two drugs the same
Efficacy:
The ability of a drug to produce a desired therapeutic effect regardless of dosage(DD)
-INTRINSIC AFFECT (how the pt feels)= Efficacy
what’s efficacy?
what’s potency?
Efficacy: The ability of a drug to produce a desired therapeutic effect regardless of dosage. A drug with high efficacy needs to stimulate only a small percentage of receptors, whereas a drug with lesser efficacy (but still considered to be a full agonist) has to activate a larger proportion of receptors.
If Drug #1 has a greater efficacy than Drug #2, then Drug #1 is capable of producing a greater maximum effect than Drug #2.
CEILING EFFECT.
dont care abt dose
Potency: the relative concentrations of two or more drugs that produce the same drug effect. Drug #I in a dose of I 0 mg produces the same magnitude of response as Drug #2 in a dose of 50 mg. The following is true: Drug # l is five times as potent as Drug #2.
DD
What’s the action of the Benzodiazepines?
Facilitates GABA receptor binding by Increasing the FREQUENCY of chloride channel opening (not duration) thus decreasing neuronal firing
FA
What’s the action of the Barbituates?
Increases DURATION of chloride channel opening, thus decreasing neuronal firing
FA
best benzo for pt with liver cirrhosis?
LOT Lorazepam Oxazepam Temazepam (wiki)
contraindication for benzo?
pregnancy
which barbiturate MOST readily penetrates the blood-brain barrier?
Thiopental
FA
A patient’s early recovery from an ultrashort-acting barbiturate is related primarily to
redistribution. breakdown in the liver. excretion in the urine. breakdown in the blood. binding to plasma proteins.
redistribution
MOA of Prozac
SSRI
