Pharm

Question 1

What are the 1st gen (or typical or neuroleptics) antipsychotics

Answer 1

• Chlorpromazine
• Fluphenazine
• haloperidol
• perphenazine

Question 2

What are the second-gen (or atypical) antipsychotics?

Answer 2

• Aripiprazole
• Asenapine
• clozapine
• iloperidone
• lurasidone
• Olanzapine
• Quetiapine
• risperidone
• ziprasidone

Question 3

What do first gen antipsychotics antagonize?

Answer 3

Dopamine, mainly D2

Question 4

What do second gen antipsychotics antagonize

Answer 4

• 5-HT2

- Also dopamine (D4>D2)

Question 5

What drugs can be used for the akathisia side effect of high potency anti-psychotics

Answer 5

-Benzos and beta-blockers

Question 6

What are the weight neutral 2nd gen anti-psychotics that can be switched to if metabolic syndrome occurs

Answer 6

• aripiprazole

- ziproasidone

Question 7

Treatment of Huntington’s Disease

Answer 7

-symptom-directed therapy, with tetrabenazine or atypical antipsychotics

Question 8

First line treatment for Tourette’s disorder

Answer 8

• Alpha-2 agonist (guanfacine)

- Clonidine is more sedating