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Flashcards in PHARM Deck (184)
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1

Penicillin VK

B lactams

Staph, strep, gonorrhea, Hflu
Recurrent RF, dental abscesses, diphtheria

A/E: Black hairy tongue, anaphylaxis

2

Amoxicillin

B lactams (Broad spectrum)
SAFE FOR PREGNANCY

1st line uncomplicated EENT
MAP USE: Meningitis, AOM, PUD, UTI, Salmonella, Extended spectrum

3

Cephalexin

Cephalosporin B lactase
SAFE FOR PREGNANCY

Cellulitis
Resp, skin, GU, bone, OM (Staph, strep, E.coli, Proteus, Klebsiella)

A/E: Penicillin allergy (10-15% cross allergy)

4

Doxycycline

Tetracycline - protein synthesis inhibitor
Broad Spectrum, take on EMPTY stomach

GC/CT if penicillin allergy, Mycoplasma, Lyme, Rickettsia, Acne, Cholera, ANTHRAX
*NOT first choice for any staph infection

A/E: Tooth discoloration (CI <8yo), photosensitivity

5

Azithromycin

Macrolide - protein synthesis inhibition
SAFE FOR PREGNANCY, take WITH food

STDS (Chlamydia, syphilis, chancoird
Respiratory (Diphtheria, TB)
2nd choice for AOM

CI: Liver disease

6

Clarithromycin

Macrolide - protein synthesis inhibition
SAFE FOR PREGNANCY, take WITH food

STDS (Chlamydia, syphilis, chancoird
Respiratory (Diphtheria, TB)
2nd choice for AOM

CI: Liver disease

7

Clindamycin

Lincosamide - protein synthesis inhibition

Topical for acne, peritonsillar abscess, neonatal GBS prophylaxis if penicillin allergy

A/E C. diff pseudomembranous colitis

8

Ciprofloxacin

Fluoroquinolone - DNA synthesis inhibitor
Broad spectrum

1st line UTIs (Pyelo = 400mg IV), GI
2nd line TB
ANTHRAX

A/E Tendon rupture, CI <18yo dt arrested growth plates

Increase Warfarin levels
Decreased absorption with antacids, Fe, Zn

9

Mupirocin

RNA synthesis inhibitor

Topical MRSA, Impetigo

10

Nitrofurantoin

NEVER use last trimester

Acute uncomplicated UTI (not E. Coli)

CI: G6PD, <3 months old, pregnancy, severe renal impairment, can cause hemolytic anemia in fetus

11

TMP/SMX

Broad Spectrum
*GIVE WITH FOLATE

Respiratory, UTI, Prostatitis, Salmonella, Shigella
2nd line AOM

A/E: Megaloblastic anemia, photosensitivity
CI: G6PD, pregnancy, <2 months
IA: Warfarin, OCP, Sulfonylureas

12

Triple Antibiotic Ointment

Allergic contact derm

Bacitracin ....[Replace with hydrocortisone for swimmer's ear, superficial bacterial infx of external auditory canal]
Neomycin (permanent SNHL)
Polymyxin B

13

TB meds

Isoniazid (can be used for latent as well)
Rifampin (red tears/urine/saliva)

*use both together for active infection
*both hepatotoxic (increase LFT)

14

Anti-Fungals

Fluconazole: Trich, systemic, organ transplants
Nystatin: Not absorbed so good for GI
Terbinafine: Nails (hepatotoxic, SJS, neutropenia)

IA: Warfarin, phenytoin, oral hypoglycemics

15

Hydroxychloroquine

DMARD

Anti-malarial
Anti-rheumatic
Anti-inflammatory

A/E: nightmares, CVD, vision, photosensitivity
CI: long term use
IA: Digoxin, alcohol

16

Mebendazole

Anti-helminthic

A/E = ALL BENT = Angioedema, Liver enzymes elevated, BM decreased, Epigastric pain, Neuro, Teratogen

CI: <2yo

17

Permethrins

Scabies

18

Metronidazole

Anti-protozoal, anaerobic infx (C.dif, PUD, BV, Trich, Giardia, Peritonsillar abscess)


A/E = NIDA = Neurotoxic, Irritated GI/GU, Disulfiram Rxn with EtOH, Allergy/a metallic taste

19

Valacyclovir

HSV (active), Hep B post exposure, EBV, CMV, Varicella

A/E: Increased AST/ALT, GI, rash, delirium

20

HIV medication

Zidouvidine - reverse transcriptase inhibitor

CI: Lactation
A/E: BM suppression = anemia, neutropenia

21

Amantadine

Anti-cholinergic dopamine agonist

Parkinsons*
No longer recommended for Influenza A
Herpes zoster

22

Oseltamivir

Influenza A &B (spray, inhaler, IV)

A/E SUICIDE

23

Interferon-a-2

Chronic HBV, HCV*, cancer, polycythemia vera, condylomata accuminata

A/E = IFN ALPHA = Inhibit BM, Flu, Neurotoxic, AI, Liver enzymes increase, Proteinuria, HYPOTHYROID/Hypotension/tachycardia, Alopecia

CI: AI, infants, pregnancy C, transplants
Extreme myelosuppression if combined with Zidovudine

24

Doxorubicin

Breast cancer, Kapos's sarcoma, multiple myeloma, ovarian CA

A/E Heart damage

25

Trastuzumab

"trust her, but not too much because shell kill your baby" - HER 2+ breast CA

A/E: Heat, lung problems, fetal harm

26

Methotrexate

Anti-metabolite/folate (DMARD)
*must sup with folate
PREGNANCY X

Cancer, RA, Abortion, psoriasis, crohns, AS

CI: Lethal with NSAIDS dt GI toxicity

27

Vinblastine

IV only (from periwinkle)

Testicular CA, Hodgkin's, Kaposi's sarcoma

A/E: Fatal intrathecally
IA: CYP3A4, Hypericum

28

Anastrazole

Aromaste inhibitor - reduces serum estradiol

Breast CA (post surgery and mets)

A/E: clots

29

Paclitaxel

"we need to gather in a pack to fight the bad CA"
Binds tubulin- effects rapidly dividing cells

Advanced ovarian CA, ovarian/breast CA mets unresponsive to 1st line drugs, non-small cell lung CA

*Give with steroids and histamine for anaphylaxis prevention

30

5-FU

Pyrimidine analogue
Sup with folate

Many cancers, topical for BCC