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Flashcards in Pharm Deck (282)
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1

Zidovudine

antiviral - treat HIV, slow disease progression, prevent transfer from mother to fetus
SE: dec RBC

2

Erythropoietin Growth Factors

Epoietin Alfa (Epogen, Procrit): identical to epo; SE: signif HTN! (inc HCT), CV events, rare PRCA; IV, IM

3

Leukopoietic Growth Factors

Filgrastim (Neupogen): identical to G-CSF, inc neutrophils/maturation in marrow, IV/SubQ

Pegfilgrastim: longer acting/ T1/2

4

Thrombopoietic Growth Factor

Oprelvekin (Neumega): identical to IL-11

5

iron deficiency treatment

ferrous sulfate - PO

6

treatment for moderate to severe sickle cell crisis

hydroxyurea (a chemotherapy for leukemia)

7

tPA

plasminogen activator, help create plasmin to DISSOLVE CLOTS and produce D Dimers

8

Heparin MoA

activates ATIII

9

Arixta

subQ, inhibit F Xa

10

Pradaxa*

PO, direct thrombin inhibitor

11

Xarelto

PO, inhibit Xa

12

Warfarin*

inhibits Vit K dependent factors 2, 7, 9, 10, protein c/s
CANT USE IN PREGNANCY** Crosses placenta
2-5mg daily
complications: hemorrhage, purple toe syndrome**

13

Clopidegrel/Clavix

anti-platelet

14

When is epogen often used?

chronic kidney failure

15

1st gen H1 blocker

Benadryl (diphenhydramine)
SE: sedative, anti-cholinergic
Tx: mild allergies, motion sickness, insomnia

16

2nd gen H1 blocker

Zyrtec (Cetirizine), Allegra (Fexofenadin), Claritin (Loratadine)
non-sedating (don't cross BBB), no anti-cholinergic, req less doses than 1st gen
Tx: allgeric rhinitis, chronic urticaria

17

Singulaire (Montelukast)

leukotriene receptor antagonist
effective for asthma!

18

Glucocorticoid

high dose suppresses inflammation and immune
most effective treatment for asthma
Adverse: adrenal insufficiency (so taper), infection, peptic ulcer, osteoporosis, warning in DM

19

Immunosuppressants

Calcineurin inhibitor: cyclosporin, tacrolimus
mTOR inhibitor: sirolimus (rapamycin), everolimus
glucocorticoids
cytotoxic drugs: azthioprine, MTX, cyclophosphamide (for refractory pts)
Antibodies
selective T cell co-stimulation blocker

20

DOC for allogenic tranplants

cyclosporin (calcineurin inhibitor)
ADVERSE: nephrotox, infection

21

H2 receptor w/histamine effects

gastric acid secretion by parietal cells

22

H1 receptor w/histamine effects

vasodilation, inc permea, bronchoconstriction, itch, pain
edema and dec BP

23

anti-cholinergic

dry mouth, tachycardia, difficult micturition

24

H2 antagonist

zantac, pepcid

25

1st line allergic rhinitis Tx for children

cromolyn (mast cell stabilizer, very safe but mod effective)

26

decongestants

sympathomimetics
Ex: Sudafed (pseudoephedrine), phenylephrine
vasoconstriction of nasal vessels
ADR: rhinitis medicamentosa (rebound congestion- leads to tolerance and hypersensitivity)*
wane off w/nasal saline
dont use >3days, not safe in children

27

most effective Tx for WATERY rhinorrhea*

Atrovent nasal spray (Ipratropium)

28

Xolair (Omalizumab)

Ab against IgE
effective to dec nasal Sx in allergic rhinitis

29

intranasal corticosteroids

flonase (fluticasone) - for mod to severe

30

What medication to avoid w/Triginous Candida and ALL CANDIDA**

Terbinafine (Lamisil) - ALL in class of Allylamine drugs like Naftifene