Pharm Adv Flashcards Preview

NPLEX2 Med Interventions > Pharm Adv > Flashcards

Flashcards in Pharm Adv Deck (100):
1

Atenolol

 

selective beta blocker (beta 1)

CI: conduction blocks, shock, PVD, DM

 

2

Propranolol

 

non-selective beta blocker (beta 1, 2)

CI: conduction blocks, shock, PVD, DM, PAD, hemorrhage

 

3

Lisinopril

 

ACEI

First line CHF

SE: dry cough, potentially fatal - severe HYPOtn, angioedema

CI: angioedema, renal stenosis

 

4

Amlodipine

 

CCB

First line Prinzmetal angina

SE: edema CI: CHF

 

5

Clonidine

 

a2-adrenergic agonist

SE: dry mouth, somnolence

CI: conduction / pacemaker

 

6

Valsartan

 

ARB

SE: dizziness

7

Spironolactone

 

K-sparing diuretic (weakest)

SE: hyperkalemia, gynecomastia

CI: impaired renal function

 

8

Hydrochlorothiazide

 

diuretic, K-wasting (middle)

nephrogenic DI

SE: hypokalemia, met. alkalosis, gout, inc insulin need

CI: sulfa sensitivity, Addison's, liver/renal dz

 

9

Furosemide

 

loop diuretic, K-wasting (strongest)

SIADH

SE: hypokalemia, hyperuricemia

CI: dehydration/electrolyte imbalance, sulfa sensitivity, liver/renal dz

 

10

Nitroglycerin

 

anti-anginas / nitrate vasodilator

SE: HA

CI: MI, anemia, Sildenafil use

 

11

Digoxin / Lanoxin

 

cardiac stimulant / digitalis glycoside

CHF, SV arrhythmia, A fib/flutter

SE: dizziness, mental disturbance

CI: toxicity, V tach/fib, obstructive cardiomyopathy

12

Amiodarone

antiarrythmic

SE: photosensitivity, skin discoloration, nervous system imbalance - ataxia, tremor, paresthesia

CI: SA or AV blocks, shock, bradycardia

 

13

Atorvastatin

HMG-CoA reductase inhibitor

SE: HA, chest pain, edema

CI: liver dz/elevated enzymes, porphyria, pregnancy X

14

Gemfibrozil

 

Fibrate 

SE: dyspepsia, abd pain

CI: liver/GB/renal dz

 

15

Bromocriptine / Parlodel

 

dopamine agonist

SE: N/V, HA, psychosis, hypotension

CI: Breast CA, lactation, ergot sensitivity, HTN, ischemic heart disease

 

16

Propythiouracil / PTU

 

antithyroid agent

SE: skin rash, warfarin interference

CI: hypothyroid, pregnancy

 

17

Levothyroxine / Synthroid

 

T4

SE: insomnia, irritability, tachycardia

CI: acute MI, thyrotoxicosis, adrenal insufficiency

18

Desiccated thyroid USP / Armour

 

T3 / T4

SE: tachycardia, insomnia, HA, diarrhea, tremor, arrhythmia

CI: acute MI, thyrotoxicosis, adrenal insufficiency

 

19

Glyburide

 

sulfonylurea - inc insulin secretion

SE: photosensitivity, weight gain

CI: DM I, DKA, sulfa allergy

 

20

Sitagliptin

 

DPP-4 inhibitor - raise incretin, inhibit glucagon release

SE: nausea, cold-like sx, photosensitivity, pancreatitis risk, jt pain

 

21

Pioglitazone

glitazone (or TZD) - reduces insulin resistance, decreases gluconeogenesis

SE: fracture, edema / CHF, anemia, bladder cancer?

CI: CHF, DM I, DKA, liver dz

22

Tamoxifen

 

SERM

SE: amenorrhea, fluid retention, nausea, hot flash, vag d/c or hemorrhage, weight loss, endometrial CA

 

23

Raloxifene / Evista

 

SERM

breast cancer, osteoporosis

SE: inc risk of DVT, PE, death from stroke, hot flashes

 

24

Mometasone

 

topical corticosteroid - medium strength

AE: inflammatory dermatoses, nasal polyps, allergies

 

25

Isotretinoin

retinoid

SE: birth defects, dyslipidemia, chelitis, conjunctivitis

CI: pregnancy X

 

26

Terbinafine / Lamisil

 

anti fungal

SE: elev. LFTs, hepatotoxic

CI: liver/renal dz, lactation

 

27

 

Misoprostol / Cytotec

 

prostaglandin

SE: diarrhea, abd pain

CI: pregnancy X

 

28

 

Sucralfate / Carafate

 

pepsin inhibitor

SE: constipation

 

29

 

Dicyclomine / Bentyl

 

antispasmodic / antimuscarinic (anticholinergic)

SE: constipation, dyspepsia, dry mouth, urinary retention

CI: obstruction, severe UC, glaucoma, reflux esophagitis

 

30

 

Loperamide

opioid analogue

SE: constipation, drowsiness

CI: bloody or infectious diarrhea, high fever, acute UC, psuedomembranous colitis

 

31

 

Bismuth subsalicylate / Pepto

 

 

salicylate (anti-secretory)

SE: nausea, black tongue

CI: aspirin, other salicylates, inc bleeding w/warfarin

 

32

 

Sodium phosphate enema

 

 

phosphoric acid salt / saline laxative

SE: acute renal failure, hypoglycemia, hyper-Na/K

CI: children, comorbid elderly; N/V, severe pain, renal impairment

 

33

 

Sulfasalazine / Azulfidine

 

 

salicylate sulfonamide (anti-inflam, anti-rheum)

SE: anorexia, HA, N/V, gastric distress, oligospermia

CI: sulfa or salicylate sensitivity, GI or urinary obstruction, porphyria, infants

 

34

 

Metoclopramide

 

 

dopamin antagonist / antiemetic

SE: dystonia/tardive dysk, fatigue, sedation, restlessness

CI: GI hemorrhage, Parkinsons, perforation, epilepsy, pheo, Rx: phenothiazines, butyrophenones

 

35

 

Prochlorperazine

 

 

dopamine antagonist / antiemetic

SE: uncontrollable restlessness, sedation, antichol. sx

CI: coma, CNS depression (meds), HTN, CVD, poor seizure control, lactation

 

36

 

Rivastigmine

 

 

cholinesterase inhibitor

SE: diarrhea, N/V, cramps, vivid dreams

 

37

 

Tolterodine

 

 

anticholinergic

SE: dry eyes/mouth, HA, dizziness, tachycardia, etc

CI: urinary retention, close-angle glaucoma

 

38

 

Finasteride

 

 

5-alpha reductase inhibitor

SE: gynecomastia, impotence, dec libido

CI: exposure to women/children

 

39

 

Tamsulosin / Flomax

 

 

selective a1 adrenergic blocker

SE: abn ejaculation, arthralgia, hypotension, HA

 

40

 

Sildenafil

 

 

vasodilator

SE: HA, epistaxis, insomnia, AV block

CI: nitrate use - fatal hypotension

 

41

 

Phenazopyridine

 

 

non-opioid analgesic

SE: GI, HA, rash, discoloration of fluids

CI: severe liver/kidney impairment

 

42

 

Deferoxamine

 

 

iron chelator

SE: neurotoxic, inc risk of cataract

CI: pregnancy, kidney dz

 

43

 

DMSA

 

 

lead, mercury, antimony, arsenic chelator

SE: N/V, diarrhea, pain, gas, elev LFTs

 

44

 

EDTA

 

 

mercury, lead, iron chelator

SE: fever, chills, fatigue, pain, arrhythmia, HA, N/V, etc

CI: anuria, renal/hepatic dz

 

45

DMPS

mercury, gold, arsenic chelator

46

 

HPV quadrivalent

 

 

SE: HA, fever, nausea, seizures

CI: allergy to yeast

 

47

 

Hepatitis A vax

 

 

CI: egg allergy, immunosuppressant use, HIV

 

48

 

Hepatitis B vax

 

 

CI: egg allergy, immunosuppressant use, HIV

 

49

 

Influenza vax

 

 

CI: live attenuated virus w/ asthma, egg allergy

 

50

 

RGE / Rotarix (RotaTeq)

 

 

SE: fever, N/V, diarrhea, gas, bronchospasm, OM, seizure

CI: hx of intussusception or GI malformation

 

51

 

Anastrozole

 

 

aromatase inhibitor

SE: hot flashes, vasodilation, fatigue, N/V

 

52

 

5-Fluorouracil / Adrucil

 

 

antimetabolite

SE: hematologic toxicity, hemorrhage, death

 

53

 

Vinblastine / Velban

 

 

mitotic inhibitor

IV only; extravasation -> cellulitis

 

54

 

Doxorubicin / Adriamycin

 

 

anthracycline

SE: myelosuppression, cardiotoxicity, liver damage, many drug rxns

 

55

 

Methotrexate

 

 

folic acid antagonist

SE: hepatotoxicity, myelosuppression, nephropathy

 

56

 

Paclitaxel

 

 

mitotic inhibitor

SE: neutropenia

CI: pregnancy, nursing, alcoholic, blood dyscrasia

 

57

 

Trastuzumab / Herceptin

 

 

HER-2 inhibitor

SE: potentially fatal heart, lung, inj site problems

 

58

 

Diphenhydramine

 

 

H1 blocker

SE: drowsiness, dry mouth, blurred vision

50mg IV + epinephrine for severe anaphylaxis

25-50mg p.o. q8 hrs over 24 hours for mild

 

59

 

Epinephrine

 

 

sympathomimetic

AE: anxiety/restlessness, tremor, dizziness, sweating, palpitations, headache,

60

 

Atropine

 

 

anti arrhythmic, anticholinergic

SE: tachy, palpitation, mydriasis, dry mouth

CI: close-angle glaucoma, myasthenia gravis, ileus, megacolon

 

61

 

Dextroamphetamine

 

 

CNS stimulant

SE: appetite loss, insomnia, palpitation, tachycardia

CI: hyperthyroid, glaucoma, HTN, MAOI

 

62

 

Methylphenidate

 

 

piperidine derivative

SE: HA, insomnia, appetite loss, N/V

CI: glaucoma, tourettes, severe anxiety

 

63

 

Oxymetazoline

 

 

decongestant

SE: stinging, burning, rebound congestion

CI: glaucoma, hyperthyroid, CVD, HTN

64

 

Pseudoephedrine

 

 

a- b-adrenergic agonist, decongestant

SE: rebound congestion, fear, anxiety, confusion

CI: severe HTN, pheo

 

65

 

Phenylephrine

 

 

sympathomimetic, decongestant

SE: anxiety, reflex bradycardia, HA, HTN, N/V

CI: HTN, v tach, glaucoma

 

66

 

Phentermine

 

 

sympathomimetic, weight loss agent

SE: hives, GI upset, palpitation, HTN, restlessness

CI: pulm HTN, hyperthyroid, CVD, glaucoma

 

67

 

Nicotine

 

 

cholinergic, smoking cessation

SE: HA, flu sx, insomnia, nausea, vivid dreams

CI: nonsmokers, recent CVA / MI, unstable angina

 

68

 

Alprazolam

 

 

anxiolytic

SE: drowsiness, depression, HA

CI: glaucoma, CNS / resp depression, OSA

 

69

 

Buspirone

 

 

azaspirodecanedione / anxiolytic

SE: dizziness, drowsiness, nausea, HA

CI: epilepsy, MAOI, renal / hepatic dz

 

70

 

Zolpidem / Ambien

 

 

hypnotic, sedative

SE: amnesia, sedation, N/V, dizziness, confusion

CI: hepatic insufficiency

 

71

 

Melatonin

 

 

tryptamine

SE: inc seizures, drowsiness, HA, disturbed circadian rhythm

CI: immunosuppressive tx

 

72

 

Carbamazepine

 

anticonvulsant, antiseizure

SE: ataxia, dizziness, drowsiness, N/V

CI: bone marrow depression, porphyria, pregnancy, MAOI

 

73

 

Phenytoin

 

 

anticonvulsant

SE: anorexia, HA, dizziness, tremor, GI upset

CI: sinus bradycardia heart block, pregnancy

 

74

 

Modafinil

 

 

CNS stimulant

SE: HA, insomnia, anxiety

CI: unmanaged HTN / arrhythmia, heart dz

 

75

 

Carisoprodol

 

 

muscle relaxant

SE: dizziness, drowsiness, GI distress, orthostatic HTN

 

76

 

Ketamine

 

 

NMDA antagonist, anesthetic

SE: HTN, inc intracranial pressure, hallucination

CI: HTN, CVA, eye injury / pressure, psych d/o

 

77

 

Cyclobenzaprine

 

 

muscle relaxant, ANS agent

SE: drowsiness, dry mouth, HA, dizziness

CI: MI, arrhythmia, liver dz

 

78

 

Levodopa-carbidopa / Sinemet

 

 

dopamine precursor / decarboxylase inhibitor

SE: dyskinesia, N/V, hallucination, depression

CI: lactation, glaucoma, MI

 

79

 

Pramipexole

 

 

dopamine agonist

SE: narcolepsy, nausea, constipation

CI: lactation

 

80

 

Amitriptyline

 

 

TCA

SE: lethargy, anticholinergic effects

CI: significant CVD, sensitivity to TCA or BZD

 

81

 

Fluoxetine

 

 

SSRI

SE: anxiety, drowsiness, insomnia, sexual dysfxn

CI: MAOI

 

82

 

Trazodone

 

phenylpiperazine

SE: drowsiness, dry mouth, HA, blurred vision, N/V

CI: MAOIs, MI, pregnancy, suicidality

 

83

 

Phenelzine

 

 

MAOI

SE: postural hypotension, dizziness, HA, insomnia

CI: uncontrolled HTN, CVD, CHF, pheo, liver/renal dz

 

84

 

Lithium / Eskalith

 

 

mood stabilizer,

SE: polyuria, fatigue, memory impairment, acne, tremor, DI

CI: renal/cardio dz, sodium depletion, dehydration, hypothyroid

 

85

 

Codeine

 

 

opioid agonist

SE: constipation, sedation, hypotension, dependence

CI: acute abd, diarrhea, resp depression, post-op in children for tonsillectomy

86

 

Hydrocodone

 

 

opioid agonist

SE: constipation, N/V, drowsiness, confusion, CV d/o

CI: obstructive airway dz, resp depression

 

87

 

Oxycodone

 

 

opioid agonist

SE: urinary spasm, CV effects, dysphoria, mood change, dependence, miosis, dec libido

CI: resp depression, alcoholism, risk of ileus, head injury

 

88

 

Methadone

 

 

opioid agonist

SE: N/V, constipation, anorexia, abd pain, resp depression

CI: resp depression, bronchial asthma, alcoholism

 

89

 

Morphine

 

 

opioid agonist

SE: pruritus, urinary retention, vomiting, HA, somnolence

CI: resp depression, asthma, ileus, obstructive airway dz, liver dz, coma, alcoholism, MAOI

 

90

 

Naltrexone

 

 

opioid antagonist

SE: N/V, HA, anorexia, insomnia, dizziness, arthralgia

CI: concurrent opioid use, liver dz

 

91

 

Sumatriptan / Imitrex

 

 

5-HT agonist

SE: paresthesia, dizziness, warm/hot sensation

CI: hx of MI / stroke, liver dz, IHD, uncontrolled HTN, PVD

 

92

 

Oxytocin / Pitocin

 

 

uterine stimulant

SE: hypotension, reflex tachycardia, uterine bleeding

fetus: jaundice, arrhythmia, bradycardia, seizure, low apgar

93

 

Hydroxyzine


 

anxiolytic, antihistamine

SE: CNS depression or paradoxical stimulation, dry mouth, thickened secretions

94

 

Fluticasone

 

 

corticosteroid

SE: URI, HA, oral candidiasis, cough

CI: status asthmatics, acute bronchospasm

 

95

 

Albuterol / Salbutamol

 

 

b2 agonist

SE: tremor, HTN, vomiting, vertigo

CI: eclampsia, uterine infx, antepartum hemorrhage, CVD

 

96

 

Tiotropium bromide

 

 

anticholinergic, antimuscarinic

SE: URI, dry mouth, sinusitis

CI: severe sensitivity to milk proteins

 

97

 

Montelukast sodium

 

 

leukotriene receptor antagonist

SE: HA

 

98

 

Dextromethorphan

 

 

antitussive

SE: dizziness, hallucination, fever, HTN

CI: risk of resp failure, MAOI, persistent cough

 

99

 

Guifenesin

 

 

expectorant

SE: N/V/discomfort, dizziness, drowsy, HA, rash

CI: persistent cough

 

100

 

Oxymetazoline

 

 

Decongestant

SE: local sting/burn, dryness, rebound congestion

CI: glaucoma, hyperthyroid, CVD, HTN, arteriosclerosis