Pharm - Basics Flashcards
(26 cards)
1
Q
2 types of Ach receptors
A
- nicotinic and muscarinic
2
Q
nicotinic Ach receptors
A
- ligand gated Na+/K+ channels
3
Q
muscarinic Ach receptors
A
- G-protein coupled receptors that usu act through 2nd messengers
4
Q
muscarinic Ach receptor subtypes
A
M1, M2, M3, M4, M5
5
Q
Alpha-1 (q)
A
- increase vascular smooth muscle contraction
- increase pupillary dilator muscle contraction (mydriasis)
- increase intestinal and bladder sphincter muscle contraction
6
Q
Alpha-2 (i)
A
- decreases sympathetic outflow
- decreases insulin release
- decreases lipolysis
- increases platelet aggregation
7
Q
Alpha-2 (i)
A
- decrease sympathetic outflow
- decrease insulin release
- decrease lipolysis
- increase platelet aggregation
8
Q
Beta-1 (s)
A
- increase heart rate
- increase contractility
- increase renin release
- increase lipolysis
9
Q
Beta-2 (s)
A
- increase vasodilation and bronchodilation
- increase heart rate
- increase contractility
- increase lipolysis
- increase insulin release
- decrease uterine tone (tocolysis)
- uterine muscle relaxation?
- increase aqueous humor production
10
Q
what are the 4 sympathetic receptors
A
- adrenergic receptors - alpha1, alpha2, beta1, beta2
11
Q
what are the 3 parasympathetic receptors?
A
- M1, M2, M3
12
Q
M1 (q)
A
- CNS enteric nervous system
13
Q
M2 (i)
A
- decrease heart rate and contractility of atria
14
Q
M3 (q)
A
- increase exocrine gland secretion (e.g. lacrimal, salivary, gastric acid)
- increase gut peristalsis
- increase bladder contraction, bronchoconstriction
- increase pupillary sphincter muscle contraction (miosis), ciliary muscle contraction (accommodation)
15
Q
Dopamine receptor types
A
D1 -stimulatory
D2- inhibitory
16
Q
D1 (s)
A
relaxes renal vascular smooth muscle
17
Q
D2 (i)
A
modulates transmitter release, especially in brain
18
Q
Histamine receptor types
A
H1- (q)
H2- stimulatory
19
Q
H1
A
- increases nasal and bronchial mucus production
- increases vascular permeability
- contraction of bronchioles, pruritis and pain
20
Q
H2
A
- increase gastric acid secretion
21
Q
vasopression receptor types
A
-V1 - (q)
V2 (s)
22
Q
H1 (q)
A
- increases nasal and bronchial mucus production
- increases vascular permeability
- contraction of bronchioles, pruritis and pain
23
Q
H2 (s)
A
- increase gastric acid secretion
24
Q
vasopressin receptor types
A
-V1 - (q)
V2 (s)
25
V1 (q)
- increase vascular smooth muscle contraction
26
V2 (s)
- increase H2O permeability and reabsorption in the collecting tubules of the kidney (V"2" is found in the "2" kidneys)
