Pharm: DM non-PO

Question 1

Pramlintide class and site of action

Answer 1

Amylin Analog – site of action: Pancreas
Amylin = peptide stored in pancreatic beta cells and co-secreted w/ insulin, regulates post-meal blood glucose
levels

Question 2

pramlintide is always used w/ ______, but must reduce by _____

Answer 2

insulin, reduce mealtime insulin by 50%

Question 3

only PO GLP-1 agonist

Answer 3

semaglutide

Question 4

3 GLP-1 agonists that have ASCVD benefit

Answer 4

semaglutide (but not PO option), dulaglutide, liraglutide (LSD)

Question 5

GLP-1 should not be used w/ which other class of DM med

Answer 5

DPP-4 inhibitors

Question 6

GLP-1 agonist main CI/BBW

Answer 6

Personal/family hx of MEDULLARY THYROID CANCER OR MEN2A/B (for the -tides, no ty-roid CA)

Question 7

liraglutide class

Answer 7

GLP-1 receptor agonists

Question 8

rapid acting insulin: onset, peak, duration

Answer 8

15 min, peak 1-2 hr, lasts 3-5hr

Question 9

short acting insulin: onset, peak, duration

Answer 9

30-60 min, peak 2-4 hr, lasts 6-8hr

Question 10

intermediate acting insulin: onset, peak, duration

Answer 10

onset 2-3 hours, peaks 4-12 hours, lasts 12-16 hours

Question 11

long acting insulin: onset, peak, duration

Answer 11

onset 1 hour, NO PEAK (continuous), lasts 24 hours

Question 12

the 3 long acting insulins

Answer 12

Insulin glargine (Lantus)
o Insulin detemir (Levemir)
o Insulin degludec (Tresiba)

Question 13

best DM med for decreasing A1C

Answer 13

insulin

Question 14

combo insulins that mix short and intermediate: which is most of content?

Answer 14

intermediate

Question 15

pioglitazone BBW

Answer 15

CHF