Pharm Drugs

Question 1

Signal transduction inhibitor drugs usually have what suffix?

Answer 1

Tyrosine kinase inhibitor: -“nib”

Question 2

Which drug inhibits tyrosine kinase, specifically BCR-abl kinase and used to tx CML?

Answer 2

Imatinib

Question 3

drug that inhibits EGFR form of tyrosine kinase?

Answer 3

Erlotinib

Question 4

Signal transduction inhibitor that inhibits BRAF?

Answer 4

Dabrafenib

Question 5

What category of drugs are used to inhibit cancer cell proliferation? What are their suffixes?

Answer 5

Monoclonal Antibodies; “-mab”

Question 6

What drug inhibits angiogenesis (BV formation)?

Answer 6

BeVacizumab

Question 7

What drug targets EGFR and is mainly used for stage IV colorectal cancer?

Answer 7

Cetuximab;

NOTE: facial rash w/ cetuximab is positive response to therapy due to EGFR–> develop acneiform-like rash on face

Question 8

Drug that induces complement mediated lysis (CD20) and must have pre-tx w/ antihistamine and acetaminophen? This drug is used for Non-Hodgkin Lymphoma

Answer 8

Rituximab

Question 9

Peptide inhibitor drug that is used to tx multiple myeloma, but can cause herpes zoster reactivation? This drug has multiple MOAs which lead to apoptosis of plasma cells!

Answer 9

Bortezomib

Question 10

One method used to prevent drug resistance is _____

Answer 10

combination therapy

Question 11

4 reasons for combo therapy rationale:

Answer 11

1. increase efficacy
2. decrease toxicity risk
3. minimizes cancer cell resistance to drug
4. target diff. phases of cell cycle

Question 12

what suffix is used for mostly humanized drugs?

Answer 12

“zumab”

Question 13

what suffix is used for mainly chimerized drugs?

Answer 13

“ximab”

Question 14

Glucocorticoids include:

Answer 14

Prednisone, prednisolone (IV), dexamethasone, betamethasone

Question 15

Corticosteroids ate believed to disrupt ____

Answer 15

intracellular communication b/w leukocytes

Question 16

What drugs are used in allergic reactions in bronchial asthma and autoimmune disorders?

Answer 16

Corticosteroids

Question 17

Which alkylating agent is broken to form a phosphoramide mustard and can cause hemorrhagic cystitis?

Answer 17

cyclophosphamide

Question 18

Which drug inhibits IL-2 synthesis and inhibits early stages of differentiation of T cells?

Answer 18

Cyclosporine

Question 19

MOA for cyclosporine?

Answer 19

inactivates a phosphatase enzyme (calcineurin)

Question 20

P-glycoprotein efflux and cytochrome P450 metabolism decreases ___ absorption significantly

Answer 20

cyclosporine

Question 21

Which drug is more specific and binds to FKBP-12 to inhibit calcineurin and is used to prevent liver and kidney rejections?

Answer 21

Tacrolimus

Question 22

Which drug inhibits Inosine Monophosphate dehydrogenase, thus blocking de novo formation of GMP?

Answer 22

Mycophenolate

Question 23

Which drug inhibits purine synthesis, thus killing lymphoid cells?

Answer 23

Azathioprine

Question 24

What xanthine oxidase inhibitor is used to prolong the half life of Azathioprine?

Answer 24

Allopurinol

Question 25

Leflunomide is approved to tx ____

Answer 25

Rheumatoid arthritis

Question 26

Leflunomide exhibits pharmacological activity via M1. What does M1 do?

Answer 26

M1 inhibits DHODH, an enzyme in the mitochondria that catalyzes a key step in de novo pyrimidine synthesis

Question 27

Which macrolide antibiotic comes from streptomyces and blocks the response of T cells to cytokines?

Answer 27

Sirolimus

Question 28

Which drug blocks IL-2 stimulated proliferation and is used in kidney/heart allografts?

Answer 28

Sirolimus

Question 29

Which drug is used in renal transplants and forms a complex w/ FKBP-12 and blocks mTOR?

Answer 29

Everolimus

Question 30

___ is used as an immunosuppressant for prophylaxis and management of organ transplant rejection

Answer 30

ATG ( anti-thymocyte globulin); tx the acute phase of allograft rejection

Question 31

What are very useful in Graft vs Host rxns?

Answer 31

Antilymphocyte and antithymocyte antibodies- they destroy T lymphocytes

Question 32

Which drug is a murine monoclonal antibody direct against CD3 molecules and is used to prevent allograft rejection?

Answer 32

Muromonab

Question 33

Which drug is directed against CD52 and is used in MS, and BM, kidney, and islet cell transplants?

Answer 33

Alemtuzumab

Question 34

Which 2 drugs are IL2 receptor blockers that are used for multi-organ transplants?

Answer 34

Basiliximab & Daclizumab

Question 35

Which drug binds to and blocks the IL-2 receptor alpha chain, known as the CD25 antigen?

Answer 35

Basiliximab

Question 36

Which drug is used to prevent atopic dermatitis and should not be used beyond the period of need or it can lead to cancer?

Answer 36

Pimecrolimus

Question 37

Which drug looks like myelin and serves as decoy to autoantibodies in order to neutralize them before tissue damage? This drug is used to tx pts w/ relapsing-remitting MS

Answer 37

Glatiramer

Question 38

Which 2 drugs are monoclonal antibodies to cytokine receptors for TNF-alpha that prevent downstream inflammatory cytokines?

Answer 38

Etanercept and Infliximab

Question 39

Which drug is approved for RA and psoriasis?

Answer 39

Etanercept

Question 40

Which drug is approved for Crohn's disease and RA?

Answer 40

Infliximab

Question 41

which drug is an anti-CD11a monoclonal antibody that helps tx severe psoriasis?

Answer 41

Efalizumab

Question 42

___ is a an LFA-3/IgG1 fusion protein that is used for plaque psoriasis?

Answer 42

Alefacept

Question 43

Rh0[D] immune globulin is a parenteral immune globulin used to prevent isoimmunization in Rh0[D]-negative women exposed to Rh0[D]-positive blood. What are the two uses of this?

Answer 43

prevents the risk of erythroblastosis fetalis & Rh hemolytic disease of the subsequent born