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Flashcards in Pharm for IBD and IBS Deck (37):
1

What are the categories of drugs used for UC?

-5-ASA
-Corticosteroids
-TNF-a inhibitors
-a-4 integrin ihibitors

2

What is the "phrase" that helps you identify a 5-ASA for UC

SALA

3

"phrase" in TNF-alpha inhibitors

MAB at the end

4

what is the one a-4 integrin inhibitor used for UC?

Vedolizumab

5

What is the one category of drug used for Crohns and not UC and what does it replace?

IL-12/23 inhibitors in place of the 5-ASAs used for UC

6

what is the one IL-12/23 inhibitor for CD?

Ustekinumab

7

What are the 2 TNF a inhibitors that are used for BOTH UC and CD

-Adalimumab
-Infliximab

8

What is the 1 TNF a inhibitor only used for UC?

Only for CD?

Golimumab

Certolizumab (C with C)

9

What is the extra a-4 integrin inhibitor that is used for CD and NOT UC?

Natalizumab
-Vedolizumab is used for both

10

3 routes of administration for 5-ASA and how they relate to extent of UC

-Oral (may be released through GI tract)
-Rectal Enema (may reach splenic flexure)
-Rectal suppository (reach the upper rectum)

11

MOA of 5-ASA

-inhibition of PG and LT production through COX and LOX pathways (arachindonic acid pathways)
-Reduction of PMN and macrophage chemotaxis
-may also inhibit NFkB

12

Contraindications for 5-ASAs

-ASA allergic patients
-Sulfasalazine contraindicated in sulfonamide-allergic patients

13

Indication for 5-ASA agents

-Mild to moderate active UC and maintenance of remission of UC

14

Which 5-ASA ONLY for maintenance therapy?

ONLY for treatment of active disease?

-Olsalazine

-Balsalazide

15

What is the other thing that sulfasolazine is indicated for?

Juvenile arthritis

16

TNF-a inhibitors are what monoclonal antibodies?

except which one that is a fragment (Fab)?

IgG

Cerolizumab

17

Side effects of TNF-a inhibitors

-infections . . TB testing pre therapy

18

Indications for TNF-a inhibitors

Moderate to severe disease . . Active and maintenance

19

TNF-a inhibitor: route is SQ every other week

Adalimumab

20

TNF-a inhibitor: route is IV infusion every 8 weeks

Infliximab

21

TNF-a inhibitor: route is SQ every 4 weeks for UC

Golimumab

22

TNF-a inhibitor: route is SQ every 4 weeks for CD

Certolizumab

23

Side effects for a-4 integrin inhibitors

-Infections . . . PML (progressive multifocal leukoencephalopathy)

24

What are the risk factors for PML associated with a-4 integrin inhibitor treatment

-Treatment >2 years
-Prior immunosuppressant treatment
-anti-JC virus antibodies (JCV)

25

Indication for a-4 integrin inhibitors

-moderate to severe treatment resistant CD and UC
-Natalizumab for CD
-Vedolizumab for BOTH

26

Which a-4 integrin inhibitor is IV every 4 weeks?

IV every 8 weeks?

-Natalizumab

-Vedolizumab

27

Side effect of IL12/23 inhibitor

infections - TB testing pre therapy

28

Indications for IL12/23 inhibitors

moderate to severe treatments resistant CD . . both active disease and maintenance

29

administration of the IL-12/23 inhibitor Ustekinumab

-IV single infusion or
-SQ every 8 weeks for maintenance

30

What are the different categories of drugs used for IBS?

-Antimuscarinic agents
-Laxative agents
-Anti-diarrheals
-Opioid agonists/antagonists
-Serotonin (5-HT) antagonists
-Guanylate cyclase-C agonists
-Selective chloride (C2) channel activators

31

Which IBS category of drugs is used to treat the abdominal pain

anti muscarinics

32

What are the 3 antimuscarinics used for IBS?

-Hyoscyamine
-Dicyclomine
-Clidinium/Chlordiazepoxide

33

the 3 categories of IBS drugs that are used for Diarrhea and their specific names

-Anti-diarrheals (Loperamide Diphenoxylate . . Bismuth)
-Opioid Agonist/Antagonist (Eluxadoline)
-Serotonin (5-HT) antagonist (Alosetron)

34

side effects of Loperamide

-typical anticholinergic effects

35

Side effects of Alosetron . . 5-HT inhibitor

-Ischemic colitis
-also constipation

36

Indication for Alosetron use

-WOMEN with chronic, severe IBS-D not responsive to other conventional therapies

37

What are the IBS drug categories used for Constipation and what are the specific names

-Guanylate cyclase-C agonists (Linaclotide)
-Selective Chloride (C2) channel activators (Lubiprostone)