Pharm of Skin

Question 1

What are some topical antibiotics used for acne?

Answer 1

clindamycin, erythromycin, metronidazole, sodium sulfacetamide, dapsone

Question 2

What type of drug is Bacitracin and Gramcidin?

Answer 2

antibacterials/peptide antibiotics

Question 3

What type of bacteria is bacitracin and Gramcidin useful against?

Answer 3

Gram - bacteria

Question 4

What are the indications for Bacitracin and Gramcidin?

Answer 4

Eradicate pathogenic Staph from anterior nares

Question 5

Complications Bacitracin and Gramcidin?

Answer 5

Contact dermatitis

Question 6

Bacitracin and Gramcidin can be used as a triple antibiotic with which drug?

Answer 6

Neomycin and Polymyxin B

Question 7

What type of drug is Polymyxin B?

Answer 7

Anti-bacterial/peptide antibiotic

Question 8

What types of bacteria is Polymyxin B useful against?

Answer 8

Gram -

Question 9

Complications Poly B?

Answer 9

neurotoxicity/nephrotoxicity

Question 10

Neomycin and Gentamicin are effective against what type of bacteria?

Answer 10

Gram -ve

Question 11

Mupirocin indications??

Answer 11

impetigo by Staph aureus or Group A beta -hemolytic Strep

Question 12

What type of bacteria is Mupirocin (pseudominic acid A) useful against?

Answer 12

gram positive aerobic, including MRSA

Question 13

MOA sodium sulfacetamide in treatment of acne?

Answer 13

inhibition of p.acnes by competitive inhibition of PABA.

Question 14

What are contraindications of Dapsone use?

Answer 14

Contraindicated in G6PD deficiency, methemoglobinemia

Question 15

What are the indications for topical azoles?

Answer 15

Dermatophytic fungal infections of the skin and Candidal infections

Question 16

Indications for ciclopirox Lamine?

Answer 16

Active against dermatophytes and candida species

Question 17

MOA of Allylamines?

Answer 17

Inhibit squalene epoxidase - first step in synthesis of ergosterol

Question 18

Name the Allymines?

Answer 18

Terbinafine
Naftifine

Question 19

What is MOA of Butenafine?

Answer 19

Inhibit squalene epoxidase - first step in synthesis of ergosterol

Question 20

Nystatin and Amphotericin B MOA?

Answer 20

Binds to fungal ergosterol and creates pores in fungal cell membrane

Question 21

Indications for Nystatin and Amphotericin B?

Answer 21

Mouth washes for oral candidiasis
Also useful for vaginal, vulvar, perianal candidiasis and diaper rash.

Question 22

Uses of Itraconazole and fluconazole?

Answer 22

treatment of dermatophytes and yeast infection

onychomycosis

Question 23

A/E of Itraconazole?

Answer 23

ventricular dysfunction

Question 24

Drug-Drug interaction of Itraconazole, fluconazole?

Answer 24

co-admin with statins result in higher risk of rhabdomyolysis

Question 25

Griseofulvin indications?

Answer 25

Active against dermatophyte infection of scalp and nails

Question 26

S/E of griseofulvin?

Answer 26

Nausea, vomiting, photosensitivity, peripheral neuritis and confusion penicillin cross sensitivity disulfiram effect

Question 27

Terbinafine indications?

Answer 27

onychomycosis

Question 28

Terbinafine indications?

Answer 28

onychomycosis

Question 29

MOA terbineafine?

Answer 29

Inhbitis lanesterol synthesis

Question 30

Use of the topical anti viral agents? Acyclovir (all the clovirs)

Answer 30

Orolabial herpes

Question 31

MOA Foscarnet

Answer 31

Inhibits viral RNA polymerase, DNA polymerase and HIV reverse transcriptase.

Question 32

Indication Imiquimod.

Answer 32

External genital and perianal warts Actinic keratosis

Question 33

MOA of Imiquimod?

Answer 33

stimulates peripheral mononuclear cells to release IFN-α and macrophages to produce IL-1, 6, 8 and TNF- α

Question 34

MOA Dupilumab?

Answer 34

IL-4α antagonist

Question 35

Indications of Dupilumab?

Answer 35

moderate to severe atopic dermatitis

Question 36

What are the indications of Tacrolimus and Pimecrolimus?

Answer 36

atopic dermatitis

Question 37

MOA Tacrolimus?

Answer 37

T-lymphocyte activation and prevent release of inflammatory cytokines

Question 38

ADR of Tacrolimus and Pimecrolimus.

Answer 38

burning sensation in the applied area

Question 39

Ectoparasiticides are typically indicated for what?

Answer 39

Treatment of scabies and pediculosis

Question 40

Indications Permethrin?

Answer 40

Most efficacious and most convenient drug for both lice and scabies

Question 41

A/E of Permetrhin

Answer 41

transient burning, tingling, itching

Question 42

Indications for Ivermectin?

Answer 42

pediculosis

Question 43

A/E of Lindane?

Answer 43

Neurotoxicity and hematotoxicity in children, new born and pregnant

Question 44

MOA Crisaborole.

Answer 44

Non-steroidal topical anti-inflammatory PDE-4 inhibitor

Question 45

Indication Crisaborole?

Answer 45

mild-to moderate atopic dermatitis

Question 46

ADR Crisaborole?

Answer 46

burning or stinging at the site of application