Pharm Questions exam

Question 1

Most effective drug to decrease gastric acid secretion as an irreversible proton pump inhibitor

Answer 1

Omeprazole

Question 2

Drug given for traveler’s diarrhea (mild to moderate)

Answer 2

Bismuth (kills bacteria and reduces inflammation in intestines)

Question 3

Synthetic Prostaglandin E1 analog, been shown to induce uterine contractions?

Answer 3

Misoprostol

Question 4

Dopamine receptor blocking activity, used to treat diabetic gastric stasis

Answer 4

Metoclopramide (increases gastric motility and emptying)

Question 5

70 year old stimulant laxative to prevent opioid induced constipation

Answer 5

Bisacodyl

Question 6

70 year old car accident needs an osmotic/saline laxative

Answer 6

Magnesium Hydroxide

Question 7

Agonist at opioid receptor without CNS effects

Answer 7

Loperamide (treats diarrhea)

Question 8

Multiple tooth extractions 65yrs old dentures, 5HT3 receptor antagonist to reduce nausea and vomiting?

Answer 8

Ondansetron (blocks serotonin receptors in brain)

Question 9

NO by inhibiting PDE-5 for degrading cGMP

Answer 9

Sildenafil

Question 10

Drug that causes hypotension when in combination with nitroglycerin

Answer 10

Sildenafil

Question 11

Orthostatic hypotension and headache are side effects of what

Answer 11

Nitroglycerin

Question 12

What anti-anginal agent associated with orthostatic hypotension

Answer 12

Amlodipine (CCB)

Question 13

Transdermal drug used for chronic stable angina too long can result in tachyphylaxis?

Answer 13

Nitroglycerin

Question 14

What is contraindicated in vasospastic angina

Answer 14

beta blockers

Question 15

What is therapeutic action of beta blockers

Answer 15

decreased requirement for myocardial oxygen (by dec’ing HR and force of contraction)

Question 16

CCB that slows conduction thru AV node and acts on L-type calcium channels

Answer 16

Verapamil

Question 17

Side effect of CCB like cerapamil or nifedipine

Answer 17

Gingival overgrowth (Hyperplasia)

Question 18

Orally active anticoagulant is a direct thrombin inhibitor

Answer 18

Dabigatran

Question 19

Heparin must bind to

Answer 19

Antithrombin 3

Question 20

Patients who previously had a heart attack are often prescribed small dose aspirin. mechanism of action?

Answer 20

Inhibits platelet COX

Question 21

What is fibrin selective

Answer 21

Alteplase (dissolves fibrin)

Question 22

65yrs old patient diagnosed with A-fib taking blood thinner measure by INR?

Answer 22

Warfarin

Question 23

which is a selective estrogen receptor modulator

Answer 23

Tamoxifen

Question 24

What synthetic estrogen is widely used in oral contraceptives slow metabolic metabolism

Answer 24

Ethinyl Estradiol

Question 25

Synthetic steroid that mimics actions of progesterone and is used in combination with oral contraceptives

Answer 25

Norethindrone

Question 26

what is synthetic and spironolactone related progestin with anti-mineralocorticoid?

Answer 26

Drospirenone

Question 27

Male patient is placed on new medication feels his tender and enlarged breasts

Answer 27

Spironolactone (diuretic that can cause gyno)

Question 28

Which of the following is NOT a benefit of combination oral contraceptives?

Answer 28

They can slightly increase risk of venous thrombosis

Question 29

What hormone is released by IUDs to prevent ovulation

Answer 29

Levonorgestrel

Question 30

What inhibits conversion of testosterone to dihydrotestosterone

Answer 30

Furosamide

Question 31

Which decreases serum LDL?

Answer 31

Ezetimibe

Question 32

Grapefruit juice and drugs that are activated by enzyme CYP3A4

Answer 32

Atorvastatin

Question 33

Drugs that bind bile acid

Answer 33

Cholestyramine (bile acid sequestrants)

Question 34

What is the mechanism for Gemfibrozil and Fenofibrate (Fibric acid derivatives)

Answer 34

Decreases plasma triglyceride levels

Question 35

Which diuretic has. sulfonamide group

Answer 35

Furosemide

Question 36

Elderly patient with pulmonary edema what is the treatment?

Answer 36

Furosemide

Question 37

Patient crisis bilateraly hearing loss, ototoxicity, patient is currently on what?

Answer 37

Furosemide

Question 38

What drug is contraindicated for patients with hypokalemia

Answer 38

Spironolactone or Acetazolamide

Question 39

College students trip to the... which drug prevents mountain sickness?

Answer 39

Acetazolamide

Question 40

60 year old female with Hashimoto, preferred treatment?

Answer 40

Oral T4 Therapy

Question 41

How do we measure the hypothyroid patient index for normal thyroid hormone levels?

Answer 41

TSH thyroid stimulating hormone

Question 42

Long term treatment for graves disease hyperthyroidism without thyrotoxicosis (thyroid storm) (over 21)

Answer 42

Radioactive iodine - destroys thyroid gland converting hyper to hypothyroidism curing graves but lifelong thyroid hormone replacement therapy

Question 43

Which step is inhibited by methimazole?

Answer 43

Iodide to Iodine and Coupling to thyroglobulin

Question 44

Hyperthyroid patient with a thyroid storm treatment?

Answer 44

Propranolol - treats thyroid storm

Question 45

Diabetic patient arrive at 2 pm with symptoms of confusion sweating and tremors is likely suffering from?

Answer 45

Hypoglycemia

Question 46

Type 1 diabetic rapid short acting insulin?

Answer 46

Insulin lispro

Question 47

Which is a long acting insulin?

Answer 47

Insulin glargine

Question 48

What medication is first line therapy for type 2 Diabetes Mellitus

Answer 48

Metformin

Question 49

What lowers blood glucose and increases insulin sensitivity?

Answer 49

Rosiglitazone

Question 50

What inhibits sodium/glucose transporter?

Answer 50

Canagliflozin

Question 51

IV lidocaine is used for?

Answer 51

Ventricular arrhythmias following MI (stabilizes electrical activity of the heart)

Question 52

60 Years old post MI arrhythmia treatment?

Answer 52

Atenolol (beta blocker)

Question 53

Patient new medication for 6 months , Blue/grey discoloration of oral cavity?

Answer 53

Amiodarone

Question 54

What causes torsade de point? (life threatening arrhythmia)

Answer 54

Sotalol (beta blocker)

Question 55

Anti-resorptive against osteoporosis?

Answer 55

Zoledronate (treats osteoporosis, inhibits bone breakdown)

Question 56

Correct regarding Bisphosphonates?

Answer 56

IV administration of bisphosphonate is preferred over oral administration bec/ it has better bioavailability

Question 57

Which conditions must be present for MRONJ?

Answer 57

a) Current or previous treatment with anti-resorptive and anti-angiogenic b) Exposed bone probe through intraoral and extraoral fistula in the maxilla c) No radiation treatment or obvious metastatic disease to the jaws d) Tooth extraction prior to development of the condition